Haemostasis in Normal Pregnancy

Stirling, Yvonne; Woolf, Linda; North, W. R. S.; Seghatchian, M.J.; Meade, T W

doi:10.1055/s-0038-1661167

Cited by 577 publications

(385 citation statements)

References 43 publications

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“…We found a significant increase of F1ϩ2, TAT and FPA in pregnancy, indicating a marked activation of the coagulation system during the third trimester of gestation [16]. Some studies have demonstrated that the increase of TAT levels may be a marker for detecting pregnancies complicated with hypertension or pre-eclampsia [17,18].…”

Section: Discussion Significant Increase Of Pap Complexes (Pͻ001) Wmentioning

confidence: 71%

Measurement of Prethrombotic Markers in the Assessment of Acquired Hypercoagulable States

López

Paloma

Rifón

et al. 1999

Thrombosis Research

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The combination of selected fibrinolytic and coaguAbstract lation measurements is useful for the detection of a hypercoagulable state in conditions characterHypercoagulable states can be detected by meaized by a risk of thrombosis. © 1999 Elsevier Scisuring activation peptides, enzyme-inhibitor comence Ltd. All rights reserved. plexes, and fibrin/fibrinogen degradation products, which are markers of hemostatic activation. A series of these prethrombotic markers has been eval-

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Section: Discussion Significant Increase Of Pap Complexes (Pͻ001) Wmentioning

confidence: 71%

Measurement of Prethrombotic Markers in the Assessment of Acquired Hypercoagulable States

López

Paloma

Rifón

et al. 1999

Thrombosis Research

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“…The incidence of pregnancy-associated deep vein thrombosis (DVT) and pulmonary embolism are estimated at 0.71 and 0.15 per 1000 deliveries, respectively 1 . Alterations in the haemostatic system, including increases in coagulation factors VII, VIII and X and fibrinogen, have been reported during pregnancy 2,3 . Early studies into platelet parameters in normal pregnancy observed enhanced platelet destruction accompanied by increased platelet production and activation 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Soluble P-selectin levels during normal pregnancy: a longitudinal study

Holmes¹

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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Objective To investigate soluble P-selectin (sP-selectin) levels and platelet parameters in normal pregnant women compared with non-pregnant control subjects. Design A longitudinal case -control study.Setting Obstetric outpatient clinic in the Jubilee Maternity Hospital, Belfast.Population One hundred and twenty normal pregnant women and 41 non-pregnant age-matched control subjects. Methods The plasma concentration of sP-selectin in pregnant women sampled at 12, 20 and 35 weeks of gestation, and, in a subgroup at three days postpartum, and non-pregnant controls sampled in parallel, was determined using a commercial quantitative sandwich immunoassay kit. Platelet parameters on each blood sample were also recorded using a SYSMEX SE 9500 analyser. Main outcome measures Plasma sP-selectin as a measure of platelet activation in normal pregnancy.Results Soluble P-selectin was significantly higher in pregnant women than in non-pregnant control subjects at 20 and 35 weeks of gestation, ( P < 0.01, and P < 0.001, respectively). Correlation analyses showed positive correlation between sP-selectin and platelet count in pregnant women at 20 and 35 weeks of gestation (r ¼ 0.247, P < 0.05 and r ¼ 0.360, P < 0.001, respectively). Soluble P-selectin concentration per platelet was also significantly higher in pregnant women than in non-pregnant control subjects at 20 and 35 weeks of gestation ( P < 0.001). Conclusions Our results show that sP-selectin concentration is significantly higher in the second and third trimester of pregnancy when compared with non-pregnant control subjects sampled in parallel. This finding clarifies previous conflicting results on platelet activation in normal pregnancy, and is in agreement with those earlier studies which reported, using other methods, increased platelet activation in normal pregnancy.

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“…Both extrinsic and intrinsic factors are involved. Normal pregnancy is accompanied by a progressive rise in clotting factors II, V, VII, VIII, IX, X, XII, fibrinogen [3,19,20,43,44], von Willebrand factor (vWF) [21] and tissue factor [45]. However stable and non-rising trends in II, X, XI were also reported [46].…”

Section: Variance In Coagulation Factorsmentioning

confidence: 99%

A Review of Hemostasis in Normal Pregnancy and Puerperium

Moiz¹

2017

Natl. j. health sci.

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Significant alterations are seen in hemostatic system during normal pregnancy and puerperium. Overall, it is a state of hypercoagulability and hypofibrinolysis mitigating the risk of severe bleeding during placental separation at delivery. On the flip side, it threatens a pregnant woman for thrombosis with the risk being four to six folds more in comparison to a non-pregnant woman. It is important to understand the hemostatic changes in normal pregnancy by all health care providers who manage pregnant women in obstetric wards, trauma, anesthesia and other circumstances. This review describes the changes in qualitative and quantitative changes in platelet, clotting factors, anticoagulants and fibrinolysis during normal pregnancy and puerperium.

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Haemostasis in Normal Pregnancy

Cited by 577 publications

References 43 publications

Measurement of Prethrombotic Markers in the Assessment of Acquired Hypercoagulable States

Measurement of Prethrombotic Markers in the Assessment of Acquired Hypercoagulable States

Soluble P-selectin levels during normal pregnancy: a longitudinal study

A Review of Hemostasis in Normal Pregnancy and Puerperium

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