Haemostasis Activation Markers in Plasma of Patients with Benign and Malignant Gynaecological Tumours: A Pilot Study

Wersch, J. W. J. Van; Peters, C.; Ubachs, Hans M. H.

doi:10.1515/cclm.1995.33.4.225

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Interestingly, we observed increasing coagulation activation along with more widespread cancer disease, since patients with localised cancer had elevated plasma levels of F1+2 and TAT solely, while patients with advanced cancer had elevated SF levels in addition. In uterine cancer, similar observations of elevated plasma levels of F1+2 along with localised disease and elevated levels of also TAT and D-dimer along with advanced disease have been reported (25). In a study of patients with melanoma, patients with localised disease had higher plasma levels of F1+2 and TAT than those with benign naevi, and patients with metastatic melanoma had higher levels of D-dimer, too (26).…”

Section: Discussionsupporting

confidence: 63%

Relationship of Coagulation Test Abnormalities to Tumour Burden and Postoperative DVT in Resected Colorectal Cancer

Iversen¹,

Thorlacius‐Ussing²

2002

Thromb Haemost

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SummaryIn a prospective study, coagulation test results were compared in 137 patients with colorectal cancer (CRC) and 39 subjects with benign colorectal diseases. Prothrombin fragment 1+2 (F1+2), thrombinantithrombin complex (TAT), and soluble fibrin (SF) were measured in plasma before and after surgery. CRC patients presented with significantly higher values of F1+2 and TAT than controls. Patients with localised CRC had elevated values of F1+2 and TAT, whereas patients with advanced CRC also had elevated SF values. TAT and SF levels correlated with tumour spread, and normal values virtually excluded advanced cancer. Postoperative deep venous thrombosis (DVT) was diagnosed by phlebography in 20% of the CRC patients. Preoperative values of the markers did not predict postoperative DVT, but postoperative values did.

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Section: Discussionsupporting

confidence: 63%

Relationship of Coagulation Test Abnormalities to Tumour Burden and Postoperative DVT in Resected Colorectal Cancer

Iversen¹,

Thorlacius‐Ussing²

2002

Thromb Haemost

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“…The binding of the two molecules leads to an inactive complex; the thrombin-antithrombin (TAT) complex. TAT levels ap pear to be one of the most informative parameters in order to discover the alteration of haemostasis especially in lung cancer [3], In previous studies we found that plas ma levels of TAT complexes were higher in neoplastic patients than in a healthy population [4,5], Particularly their values seem to correlate with the stage of the disease, as observed by Rocha et al [6] and Lindahl et al [7] in patients with various malignant diseases [6,7] and by Van Wersch et al [8] in patients with gynecological tumours. Recently, TAT complexes were found to be higher also in those suffering from advanced pulmonary carcinoma as compared with patients with limited disease [9].…”

Section: Introductionmentioning

confidence: 51%

Plasma Thrombin-Antithrombin Complexes, Latent Coagulation Disorders and Metastatic Spread in Lung Cancer: A Longitudinal Study

et al. 1996

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In patients affected with different tumours, disorders concerning clotting are frequently observed. The biological processes leading to coagulation are probably involved in the mechanisms of metastasis. We studied plasma levels of thrombin-antithrombin III complexes (TAT) in 90 patients affected with lung tumours subgrouped in small cell and non-small cell (NSC) lung cancer: 17 patients had no evidence of disease after surgery (NE); the remaining 73 patients were divided according to the absence (LOC) or the presence (META) of metastases. All the patients were followed up for several months. In all the lung cancer patient groups, at the beginning of the study we detected TAT levels that were higher than in controls. During the follow-up period, the NSC-NE patients with no recurrence of the disease as well as the NSC-LOC patients responding to the treatment had a decrease in TAT levels (p < 0.01 and p < 0.05, respectively). The NSC-META patients with progression of their disease had, in contrast, an increase in TAT levels (p < 0.01). Our data reveal the presence of ‘latent coagulation disorders’ as assessed by the presence of high TAT levels in the majority of lung cancer patients. The follow-up study indicates that in the NSC group, a relation exists between coagulation activation and rate of tumour progression and/or response to treatment. In cancer patients the early detection of coagulation disorders could also allow, therefore, the prevention of thromboembolism and/or haemorrhage by administration of appropriate treatment.

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Occlusive Vascular Diseases in Oral Contraceptive Users

Godsland

Winkler

Lidegaard

et al. 2000

Drugs

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Despite being an unprecedented departure from normal physiology, the combined oral contraceptive is not only highly effective, but it also has a remarkably good safety record. Concerns over safety persist, though, particularly with regard to venous thromboembolism (VTE), stroke and myocardial infarction (MI). Epidemiological studies consistently show an increase in risk of VTE, but the results are more contentious with regard to arterial diseases. Despite 40 years of research, the mechanisms behind these adverse effects are not understood. In this review, we integrate information from published studies of the epidemiology and pathology of the occlusive vascular diseases and their risk factors to identify likely explanations for pathogenesis in oral contraceptive users. Oral contraceptives induce both prothrombotic and fibrinolytic changes in haemostatic factors and an imbalance in haemostasis is likely to be important in oral contraceptive-induced VTE. The complexity of the changes involved and the difficulty of ascribing clinical significance has meant that uncertainty persists. A seriously under-researched area concerns vascular changes in oral contraceptive users. Histologically, endothelial and intimal proliferation have been identified in women exposed to high plasma estrogen concentrations and these lesions are associated with thrombotic occlusion. Other structural changes may result in increased vascular permeability, loss of vascular tone and venous stasis. With regard to arterial disease risk, epidemiological information relating to dose effects and joint effects with other risk factors, and studies of pathology and changes in risk factors, suggests that oral contraceptive use per se does not cause arterial disease. It can, nevertheless, synergise very powerfully with subclinical endothelial damage to promote arterial occlusion. Accordingly, the prothrombotic effects of the oral contraceptive estrogen intervene in a cycle of endothelial damage and repair which would otherwise remain clinically silent or would ultimately progress - in, for example, the presence of cigarette smoking or hypertension - to atherosclerosis. Future work in this area should focus on modification of the effects of established risk factors by oral contraceptive use rather than modification of the supposed risk of oral contraceptive use by established risk factors. Attempts to understand vascular occlusion in oral contraceptive users in terms of the general features of VTE or with reference to atherosclerosis may be limiting, and future work needs to acknowledge that such occlusions may have unique features. Unequivocal identification of the mechanisms involved would contribute considerably to the alleviation of fears over vascular disease and to the development of even safer formulations.

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Haemostasis Activation Markers in Plasma of Patients with Benign and Malignant Gynaecological Tumours: A Pilot Study

Cited by 3 publications

References 21 publications

Relationship of Coagulation Test Abnormalities to Tumour Burden and Postoperative DVT in Resected Colorectal Cancer

Relationship of Coagulation Test Abnormalities to Tumour Burden and Postoperative DVT in Resected Colorectal Cancer

Plasma Thrombin-Antithrombin Complexes, Latent Coagulation Disorders and Metastatic Spread in Lung Cancer: A Longitudinal Study

Occlusive Vascular Diseases in Oral Contraceptive Users

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