Haemorrhagic shock-encephalopathy syndrome: plasmapheresis as a therapeutic approach

Roth, Bernhard; Younossi-Hartenstein, Amelia; Schröder, R; Hörnchen, H; Heymans, Lothar

doi:10.1007/bf00647296

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…Other aetiopathogenic theories, for example that HSES results from deficiencies of protease inhibitors,24 abnormalities in stress protein production,25 or bacterial endotoxin leaking through a gut lining damaged by splanchnic ischaemia, 8 are all compatible with the notion that the pathogenic cascade ofevents culminating in HSES results from a heat induced trigger in a genetically determined, susceptible individual. The rarity of HSES could be compatible with this hypothesis, because an improbable combination of risk factors would have to be present to initiate the cascade.…”

Section: Discussionmentioning

confidence: 99%

“…A child had to be under 16 years of age with acute onset of: (1) encephalopathy, (2) shock, (3) disseminated intravascular coagulation, (4) diarrhoea (may be bloody), (5) falling haemoglobin concentration and platelet counts, (6) acidosis, (7) raised hepatocellular enzymes, (8) renal function impairment, and (9) negative cultures of blood and cerebrospinal fluid.…”

Section: Case Definitionmentioning

confidence: 99%

See 1 more Smart Citation

Haemorrhagic shock encephalopathy syndrome in the British Isles.

Bacon

Hall

1992

Archives of Disease in Childhood

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The aetiopathogenesis of haemorrhagic shock encephalopathy syndrome (HSES) remains unclear and after concern that a novel environmental agent was the cause, There was no microbiological or epidemiological evidence to support the emergence of a novel environmental agent. Many of the features of HSES were, however, the same as those described in heat stroke and we suggest that the two conditions are the same even though there is usually no history of overt overheating.

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Section: Discussionmentioning

confidence: 99%

Section: Case Definitionmentioning

confidence: 99%

Haemorrhagic shock encephalopathy syndrome in the British Isles.

Bacon

Hall

1992

Archives of Disease in Childhood

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“…No specific treatment for HSES exists. There have been only a few reports concerning the use of PE in cases of HSES (25), and its usefulness is unknown. In this study, concomitant CHDF therapy was performed at an early stage in 2 patients with HSES.…”

Section: Discussionmentioning

confidence: 99%

Cytokine Removal by Plasma Exchange with Continuous Hemodiafiltration in Critically Ill Patients

Nakae¹,

Asanuma

Tajimi³

2002

Therapeutic Apheresis

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The effectiveness of plasma exchange (PE) with continuous hemodiafiltration (CHDF) in the treatment of critically ill patients was evaluated based on changes in cytokine levels. Twenty-six patients with acute hepatic failure were treated with PE (PE group) or PE and CHDF (PE+CHDF group), and the levels of cytokines such as tumor necrosis factor (TNF)-␣, interleukin (IL)-6, and IL-8 were determined before and after treatment. Bilirubin levels were significantly lower after treatment in both the PE and PE+CHDF groups. There were no significant differences in TNF-␣ levels before and after treatment in the PE group, but the TNF-␣ level was significantly lower after treatment in the PE+CHDF group. There were no significant differences in the IL-6 levels before and after treatment in both the PE and PE+CHDF groups. There were no significant differences in IL-8 levels before and after treatment in the PE group, but the IL-8 level was significantly lower after treatment in the PE+CHDF group. PE with CHDF therapy was given to 5 patients with acutely aggravated autoimmune diseases, 2 patients with hemorrhagic shock and encephalopathy syndrome, and 3 patients with thrombotic microangiopathy. The results suggested that PE with CHDF therapy are useful in critically ill patients with suspected hypercytokinemia.

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Hemorrhagic Shock and Encephalopathy

Chaves‐Carballo¹

1990

Am J Dis Child

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Haemorrhagic shock-encephalopathy syndrome: plasmapheresis as a therapeutic approach

Cited by 8 publications

References 10 publications

Haemorrhagic shock encephalopathy syndrome in the British Isles.

Haemorrhagic shock encephalopathy syndrome in the British Isles.

Cytokine Removal by Plasma Exchange with Continuous Hemodiafiltration in Critically Ill Patients

Hemorrhagic Shock and Encephalopathy

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