Haemorrhagic and necrotizing pancreatitis

Acute pancreatitis in Hong Kong

“…Although the exact incidence of this more severe form of pancreatitis in any reported series is unknown (but estimated to be between 10 and 25 per cent; Glazer, 1975), the mortality rate of haemorrhagic pancreatitis, when diagnosed at operation, was very high. In 169 emergency operations during the acute attack, 25 cases of haemorrhagic pancreatitis were found and 18 of them subsequently died (72 per cent).…”

The liver and pancreas in acute necrotising pancreatitis.

“…Trypsin probably plays some part in the development of acute pancreatitis (Glazer, 1975;Hermon-Taylor, 1977), and Novis et al (1975) found a significant excess of heterozygous (PiMZ) acl-antitrypsin deficient subjects among 110 cases of chronic pancreatitis. In the 26 livers examined, only one had antitrypsin bodies, which is the expected incidence in the general population (Blenkinsopp and Haffenden, 1977).…”

“…In the 26 livers examined, only one had antitrypsin bodies, which is the expected incidence in the general population (Blenkinsopp and Haffenden, 1977). Glazer (1975) has reviewed the various theories of pathogenesis of acute pancreatitis, including McCutcheon's (1968) proposal of reflux of activated duodenal enzymes. The present study provides no evidence for or against this theory but supports it to the extent that neither duct obstruction nor vascular occlusion appears to be necessary.…”

The Management of Acute Pancreatitis

“…Abdominal signs are inconstant but tenderness is usually elicited. Skin discolouration, although often cited, is not diagnostic, rarely seen and if extensive more likely to result from a ruptured aortic aneurism (Glazer 1975).…”