Haemophilus influenzae type b polysaccharidetetanus protein conjugate vaccine does not depress serologic responses to diphtheria, tetanus or pertussis antigens when coadministered in the same syringe with diphtheria-tetanus-pertussis vaccine at two, four and six months of age

Evidence for induction of polysaccharide specific B-cell-memory in the 1st year of life: plain Haemophilus influenzae type b - PRP (Hib) boosters children primed with a tetanus-conjugate Hib-DTPa-HBV combined vaccine

“…Our study extends these observations in showing that not only can tetanus-PRP be successfully administered when reconstituted with a DTPa vaccine, but that even the inclusion of a third vaccine, against hepatitis B, does not compromise the priming of immunological memory. The serological responses against the DTPa-HBV antigens were not affected by the inclusion or simultaneous administration of the Hib vaccine, as has previously been reported [1,2]. Nearly all the children had seroprotective levels of anti-diphtheria, anti-tetanus and anti-HBsAg antibodies, and over 92% of the subjects displayed seroresponses to the three pertussis antigens with GMCs similar to those seen in protective efficacy trials for DTPa in Italy [9] and Germany [20].…”

Lot-to-Lot Consistency of a Combined Hexavalent Diptheria-Tentanus-Acellular-Pertussis, Hepatitis B, Inactivated Polio and Haemophilus b Conjugate Vaccine, Adminstered to Healthy Chilean Infants at 2, 4 and 6 Months of Age

“…8,10,27 GMTs of anti-PRP antibodies were lower than those observed in a study on interactions between DTaP, IPV and Act-HIB ® vaccines in Chilean infants; 27 however, more than 97% of the infants reached seroprotective levels of anti-PRP antibodies (>0.15 µg/mL). This seroprotection rate after three doses of PRP-T is as high as those previously reported in Chilean infants, 31,32 and the GMTs were greater than the ones measured with the same vaccine in French infants. 8 The markedly greater immune response to PRP-T in Chilean infants versus North American or European infants has been observed consistently.…”

“…10,27,[31][32][33] In early studies, 25% of Chilean infants reached a concentration >1.0 mcg of PRP antibody per ml of serum after the first primary dose of vaccine. [31][32][33] A case/control study undertaken to try and identify factors associated with this robust serologic responses revealed that infants who mounted such enhanced responses came from significantly lower socioeconomic level households than the other infants, and their parents had less education. 33 The response to poliovirus vaccines was at least of the magnitude previously measured in Chilean infants, either with attenuated oral or enhanced-inactivated polio vaccines.…”

Anti-Polyribosylribitol Phosphate Antibody Concentrations and Avidities in Children since the Start ofHaemophilus influenzaeType b Immunization of Infants in the United Kingdom

“…Reconstituting Hib glyco-conjugate vaccines with DTwP can result in lower anti-PRP concentrations immediately following infant immunization compared to administering vaccines concurrently at different sites (3,17,18,24). However, other studies have found no significant difference between groups receiving mixed or separate vaccines (4,8,34,39). Almost all of the comparative studies relate to anti-PRP concentrations at 1 month after primary immunization, and there is little information on whether differences in immunogenicity are reflected in subsequent antibody persistence.…”