Hæmophilus Influenzæ Precipitins in the Serum of Patients With Chronic Bronchial Disorders

Burns, M. W.; May, J. Robert

doi:10.1016/s0140-6736(67)92895-4

Cited by 70 publications

(36 citation statements)

References 7 publications

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“…We confirmed that H. influenzae is associated with purulent sputum, as frequently observed in the past (7), and that biotype II is the most common isolate (2,12). In five of nine cases, multiple biotypes were present; this has not been reported for sputum.…”

Section: Discussionsupporting

confidence: 84%

“…H. influenzae may be found in the pharynx but is rarely found in saliva (21,29). Nonencapsulated H. influenzae is associated with purulent sputum, evokes an antibody response, and may cause acute bronchitis and exacerbations of chronic obstructive pulmonary disease (COPD) (7,26,30). H. parainfluenzae is part of the normal oral flora (29) and may occasionally cause serious infections such as infective endocarditis (1).…”

mentioning

confidence: 99%

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Ecology of Haemophilus influenzae and Haemophilus parainfluenzae in sputum and saliva and effects of antibiotics on their distribution in patients with lower respiratory tract infections

Foweraker

Cooke

Hawkey

1993

Antimicrob Agents Chemother

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Nine patients with lower respiratory tract infections were used to study in detail the effect of ampicillin or erythromycin on the colonization patterns of Haemophilus influenzae and Haemophilus parainfluenzae in sputum and saliva. H. influenzae was isolated from purulent sputum of eight patients before the start of treatment. Ampicillin was more effective than erythromycin at clearing H. influenzae from sputum and in decreasing purulence. By careful characterization of multiple strains, the changes in biotype distribution and antibiotic susceptibility patterns were shown. Five biotypes of H. influenzae were associated with chest infection, with type H predominating. Mixed biotype infections occurred in five patients. Most saliva contained multiple biotypes of H. parainfluenzae. Neither antibiotic selected resistant haemophili in saliva or sputum. After treatment with ampicillin, the mucoid sputum was colonized with ampicillin-susceptible H. parainfluenzae biotypes previously found in saliva. We postulate that as inflammation decreases at the bronchial mucosa, the ampicillin concentration drops, allowing ampicillin-susceptible oral H. parainfluenzae isolates to seed the residual mucoid sputum.

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Section: Discussionsupporting

confidence: 84%

mentioning

confidence: 99%

Ecology of Haemophilus influenzae and Haemophilus parainfluenzae in sputum and saliva and effects of antibiotics on their distribution in patients with lower respiratory tract infections

Foweraker

Cooke

Hawkey

1993

Antimicrob Agents Chemother

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“…Thereafter the supernatant was dialyzed against distilled water for two days. After that the solution was lyophilized and the powder was weighed (Burns and May 1967).…”

Section: Methodsmentioning

confidence: 99%

Invasion of Haemophilus influenazae and Pseudomonas aeruginosa in humans.

Suzuki

Juwono

Matsumoto

1985

Tohoku J. Exp. Med.

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Levels of serum IgG antibodies to somatic antigens of Haemophilus influenzae and Pseudomonas aeruginosa were determined in 127 healthy people, 37 patients with chronic bronchitis and 20 patients with bronchiectasis by enzyme-linked immunosorbent assay. The logarithmic mean titers of antibodies to Haemophilus influenzae and Pseudomonas aeruginosa were significantly higher in the patients with chronic bronchitis and bronchiectasis than in healthy people. The invasion rate of Haemophilus influenzae was identical in healthy people, chronic bronchitis and bronchiectasis, while that of Pseudomonas aeruginosa was significantly lower in healthy people than in chronic bronchitis and bronchiectasis patients. These results indicate that patients with chronic bronchitis and bronchiectasis may often have recurrence and are easily infected because of lowered defense mechanisms in the respiratory tract. bacterial antibody ; Haemophilus influenzae infection ; Pseudomonas aeruginosa infection

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“…Firstly, there is gener al agreement that a close association exists between this organism and chronic bronchitis. Secondly, it is possible to obtain evidence of infection by H. influenzae from the presence in serum of precipitin antibodies [Burns and May, 1967]. It was hoped that serological identification of infection by H. influenzae would prove to be more reliable than isolation of the organism from sputum.…”

Section: Introductionmentioning

confidence: 99%

Infection and Chronic Bronchitis

Gregg¹

1969

Respiration

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Hæmophilus Influenzæ Precipitins in the Serum of Patients With Chronic Bronchial Disorders

Cited by 70 publications

References 7 publications

Ecology of Haemophilus influenzae and Haemophilus parainfluenzae in sputum and saliva and effects of antibiotics on their distribution in patients with lower respiratory tract infections

Ecology of Haemophilus influenzae and Haemophilus parainfluenzae in sputum and saliva and effects of antibiotics on their distribution in patients with lower respiratory tract infections

Invasion of Haemophilus influenazae and Pseudomonas aeruginosa in humans.

Infection and Chronic Bronchitis

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