Haemophilus influenzae pneumonia in Melanesian adults: report of 15 cases.

Barnes, David J.; Naraqi, S; Igo, J D

doi:10.1136/thx.42.11.889

Cited by 14 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…at species-level. The specific qRT-PCR confirmed 12 of 14 RPM-positive results for H. influenzae which might be the causative agents of CAP (Barnes et al, 1987 ) and was of particular importance for respiratory infections in children (Nascimento-Carvalho, 2001 ). Haemophilus parainfluenzae and Haemophilus haemolyticus , the other two types of Haemophilus spp., were commonly considered as commensals colonizing the upper respiratory tract asymptomatically (Mukundan et al, 2007 ; Murphy et al, 2007 ).…”

Section: Discussionmentioning

confidence: 57%

Association of targeted multiplex PCR with resequencing microarray for the detection of multiple respiratory pathogens

Shen

Zhu

Wang³

et al. 2015

Front. Microbiol.

View full text Add to dashboard Cite

A large number of viral and bacterial organisms are responsible for community-acquired pneumonia (CAP) which contributes to substantial burden on health management. A new resequencing microarray (RPM-IVDC1) associated with targeted multiplex PCR was recently developed and validated for multiple respiratory viruses detection and discrimination. In this study, we evaluated the capability of RPM-IVDC1 for simultaneous identification of multiple viral and bacterial organisms. The nasopharyngeal aspirates (NPAs) of 110 consecutive CAP patients, aged from 1 month to 96 years old, were collected from five distinct general hospitals in Beijing during 1-year period. The samples were subjected to the RPM-IVDC1 established protocol as compared to a real-time PCR (qRT-PCR), which was used as standard. The results of virus detection were consistent with those previously described. A total of 37 of Streptococcus pneumoniae, 14 of Haemophilus influenzae, 10 of Mycoplasma pneumoniae, two of Klebsiella pneumoniae and one of Moraxella catarrhalis were detected by RPM-IVDC1. The sensitivities and specificities were compared with those of qRT-PCR for S. pneumoniae (100, 100%, respectively), H. influenzae (92.3, 97.9%, respectively), M. pneumoniae (69.2, 99.0%, respectively), K. pneumoniae (100, 100%, respectively), and M. catarrhalis (100, 100%, respectively). Additional 22 of Streptococcus spp., 24 of Haemophilus spp. and 16 of Neisseria spp. were identified. In addition, methicillin-resistant and carbapenemases allele were also found in nine of Staphylococcus spp. and one of K. pneumoniae, respectively. These results demonstrated the capability of RPM-IVDC1 for simultaneous detection of broad-spectrum respiratory pathogens in complex backgrounds and the advantage of accessing to the actual sequences, showing great potential use of epidemic outbreak investigation. The detection results should be carefully interpreted when introducing this technique in the clinical diagnostics.

show abstract

Section: Discussionmentioning

confidence: 57%

Association of targeted multiplex PCR with resequencing microarray for the detection of multiple respiratory pathogens

Shen

Zhu

Wang³

et al. 2015

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Over the last several decades, cases of HINP have been described in patients with COPD, alcoholism, immunological deficiencies, sarcoidosis, and other conditions [6,8,23]. BARNES et al [4] confirmed the association of H. influenzae community acquired pneumonia with chronic bronchitis, but did not establish its association with alcoholism or other conditions. This type of pneumonia was produced by microaspiration of oropharyngeal contents, and this mechanism has been confirmed in an experimental model [24].…”

Section: Discussionmentioning

confidence: 99%

“…Haemophilus influenzae (HI) frequently colonizes the trachea and major bronchi of smokers and patients with chronic obstructive pulmonary disease (COPD) [1]. H. influenzae infection is a common aetiology of exacerbations in COPD [2], and causes community-acquired pneumonia (CAP) in children and adults with chronic diseases, such as COPD or alcoholism [3,4]. Nosocomial outbreaks of H. influenzae infection have recently been reported both in children and adults with chronic underlying disease [5].…”

mentioning

confidence: 99%

Risk factors for the development of Haemophilus influenzae pneumonia in hospitalized adults

Barreiro¹,

Dorca²,

Esteban³

et al. 1995

Eur Respir J

View full text Add to dashboard Cite

Potential risk factors for developing Haemophilus influenzae nosocomial pneumonia have not been sufficiently studied. We wanted to investigate the incidence and risk factors for the development of Haemophilus influenzae pneumonia in the hospital by means of a multivariate analysis. A total of 468 cases of nosocomial pneumonia were observed during the study period, 317 (68%) of which were aetiologically diagnosed by means of highly reliable methods, and H. influenzae was isolated in 57 of them. Fifty of the 57 episodes of H. influenzae pneumonia occurred in mechanically-ventilated patients. Underlying diseases were: medical in 12 cases, surgical in 15 cases, and traumatological in 22. Variables associated with Haemophilus influenzae nosocomial pneumonia in intubated patients after the univariate analysis were: "period between admission and pneumonia 2-7 days" and "no previous antibiotics". A multivariate analysis demonstrated that the variables "no previous antibiotics" and "coma on admission" were risk factors for H. influenzae pneumonia. In nonintubated patients, no risk factors were found for H. influenzae pneumonia compared with other nosocomial pneumonia. We conclude that H. influenzae was involved in 57 out of 317 (18%) of nosocomial pneumonia registered in our institution, and the majority of patients (50 out of 57) were mechanically-ventilated. In this particular subgroup, coma of the patient on admission to hospital and absence of antibiotic treatment prior to developing pneumonia constitute two definite risk factors for developing H. influenzae nosocomial pneumonia.

show abstract

“…Another study conducted in Papua New Guinea prospectively examined 170 adult patients with acute CAP. Of these, H. influenzae was identified as the sole pathogen in 15 (9%) patients: 7 Hib, 4 serotype a (Hia), 1 Hic, and 3 NTHi [118]. Chronic lung disease was more common in patients with H. influenzae pneumonia than CAP due to other organisms.…”

Section: H Influenzae As a Cause Of Community-acquired Pneumonia mentioning

confidence: 99%

A review of the role of Haemophilus influenzae in community-acquired pneumonia

Slack

2015

Pneumonia

View full text Add to dashboard Cite

/Ŷ ĂŶ ĞƌĂ ǁŚĞŶ ,ĂĞŵŽƉŚŝůƵƐ ŝŶŇƵĞŶǌĂĞ ƚǇƉĞ ď ;,ŝďͿ ĐŽŶũƵŐĂƚĞ |ĂĐĐŝŶĞ ŝƐ ǁŝĚĞůǇ ƵƐĞĚ͕ ƚŚĞ ŝŶĐŝĚĞŶĐĞ ŽĨ ,ŝď ĂƐ Ă ĐĂƵƐĞ ŽĨ ĐŽŵŵƵŶŝƚǇͲĂĐƋƵŝƌĞĚ ƉŶĞƵŵŽŶŝĂ ; WͿ ŚĂƐ ĚƌĂŵĂƟĐĂůůǇ ĚĞĐůŝŶĞĚ͘ EŽŶͲƚǇƉĞĂďůĞ ,͘ ŝŶŇƵĞŶǌĂĞ ;Ed,ŝͿ ƐƚƌĂŝŶƐ ĂŶĚ͕ ŽĐĐĂƐŝŽŶĂůůǇ͕ ŽƚŚĞƌ ĞŶĐĂƉƐƵůĂƚĞĚ ƐĞƌŽƚǇƉĞƐ ŽĨ ,͘ ŝŶŇƵĞŶǌĂĞ ĂƌĞ ŶŽǁ ƚŚĞ ĐĂƵƐĞ ŽĨ ƚŚĞ ŵĂũŽƌŝƚǇ ŽĨ ŝŶ|ĂƐŝ|Ğ ,͘ ŝŶŇƵĞŶǌĂĞ ŝŶĨĞĐƟŽŶƐ͕ ŝŶĐůƵĚŝŶŐ ďĂĐƚĞƌĂĞŵŝĐ W͘ Ed,ŝ ŚĂ|Ğ ůŽŶŐ ďĞĞŶ ƌĞĐŽŐŶŝƐĞĚ ĂƐ ĂŶ ŝŵƉŽƌƚĂŶƚ ĐĂƵƐĞ ŽĨ ůŽǁĞƌ ƌĞƐƉŝƌĂƚŽƌǇ ƚƌĂĐƚ ŝŶĨĞĐƟŽŶ͕ ŝŶĐůƵĚŝŶŐ ƉŶĞƵŵŽŶŝĂ͕ ŝŶ ĂĚƵůƚƐ͕ ĞƐƉĞĐŝĂůůǇ ƚŚŽƐĞ ǁŝƚŚ ƵŶĚĞƌůǇŝŶŐ ĚŝƐĞĂƐĞƐ͘ dŚĞ ƌŽůĞ ŽĨ Ed,ŝ ĂƐ Ă ĐĂƵƐĞ ŽĨ ŶŽŶͲďĂĐƚĞƌĂĞŵŝĐ W ŝŶ ĐŚŝůĚƌĞŶ ŝƐ ůĞƐƐ ĐůĞĂƌ͘ /Ŷ ƚŚŝƐ ƌĞ|ŝĞǁ ƚŚĞ Ğ|ŝĚĞŶĐĞ ĨŽƌ ƚŚĞ ƌŽůĞ ŽĨ Ed,ŝ ĂŶĚ ĐĂƉƐƵůĂƚĞĚ ƐƚƌĂŝŶƐ ŽĨ ,͘ ŝŶŇƵĞŶǌĂĞ ǁŝůů ďĞ ĞǆĂŵŝŶĞĚ͘

show abstract

Haemophilus influenzae pneumonia in Melanesian adults: report of 15 cases.

Cited by 14 publications

References 20 publications

Association of targeted multiplex PCR with resequencing microarray for the detection of multiple respiratory pathogens

Association of targeted multiplex PCR with resequencing microarray for the detection of multiple respiratory pathogens

Risk factors for the development of Haemophilus influenzae pneumonia in hospitalized adults

A review of the role of Haemophilus influenzae in community-acquired pneumonia

Contact Info

Product

Resources

About