Haemophilus influenzae and Haemophilus parainfluenza in Cystic Fibrosis: 15 Years Experience

Ebbing, Rosanne; Robertson, Colin F.; Robinson, Philip

doi:10.4172/2161-0703.s5-004

Cited by 8 publications

(16 citation statements)

References 19 publications

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“…The increasing emergence and spread of haemophili resistance has become a distinct problem [10]. The primary mechanism of H. influenzae resistance to beta-lactam antibiotics is the production of beta-lactamases.…”

Section: Discussionmentioning

confidence: 99%

“…H. influenzae occurs in 3-5% of all children between 2 and 3 years of age, with the highest degree of colonization being within the respiratory tract mucous membranes. On the contrary, in adults, about 50% of all individuals are colonized with haemophili [10,30].…”

Section: Introductionmentioning

confidence: 98%

“…These bacteria colonize the airways of people of all ages, both healthy and with different diseases [10].…”

Section: Introductionmentioning

confidence: 99%

“…These include the pathogenic H. influenzae species. Children under six months of age rarely are the carriers of these bacteria, because of the presence of maternal antibodies protecting against them [10,15,40,48]. However, such passive immunity obtained from the mother's milk does not last long, and 90% of all children >1 year of age are carriers of these bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…They are also frequently identified in chronic obstructive pulmonary disease (COPD) and even in acute septic arthritis or osteoarthritis [6,9,17,18,21,38,55]. Currently, H. parainfluenzae is more commonly recognized as an opportunistic pathogen rather than a normal inhabitant [10], especially according to its increased resistance to beta-lactams [11].…”

Section: Introductionmentioning

confidence: 99%

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Phenotypic diversity of Haemophilus influenzae and Haemophilus parainfluenzae isolates depending on origin and health condition

Andrzejczuk

Kosikowska

Malm

et al. 2017

Current Issues in Pharmacy and Medical Sciences

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Background. Haemophili are common human microbiota representatives. The aim of our study was to investigate a diversity of Haemophilus spp. isolates selected from clinical specimens on the basis of biochemical characteristics, biotypes distribution, protein profiles and antimicrobial resistance. Results. A total of 893/1025 (87%) of haemophili isolates were identified: 260/1025 (25%) as H. influenzae and 633/1025 (62%) as H. parainfluenzae. Moreover, a group of 107/1025 (10%) isolates without species identification (with e.g. abnormal numerical profile) was described as Haemophilus spp. Within the H. influenzae isolates, biotypes II and III were in a great majority (92/893; 10%, each), whereas among H. parainfluenzae, the most commonly occurring was biotype I and II (301/893, 34% and 178/893, 20%, respectively). A similar prevalence of biotypes was obtained regardless of the patient’s age or health condition or the type of specimen. A production of beta-lactamases was shown in 46/893 (5%) haemophili, both H. influenzae (13/46, 28%) and H. parainfluenzae (33/46, 72%) isolates. On the basis of haemophili biochemical characteristics, the cluster analysis using the UPGMA method demonstrated a high degree of phenotypic similarity due to a small distances between isolates taken from both unhealthy children and adults. Conclusion. Based on biochemical characteristics, about 90% of haemophili clinical isolates representing human-specific respiratory microbiota were positively identified as H. influenzae and H. parainfluenzae. The same differences in biotypes and antimicrobial resistance among isolates selected from healthy people or from patients with chronic and recurrent diseases were detected.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

“…These bacteria colonize the airways of people of all ages, both healthy and with different diseases [10].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Phenotypic diversity of Haemophilus influenzae and Haemophilus parainfluenzae isolates depending on origin and health condition

Andrzejczuk

Kosikowska

Malm

et al. 2017

Current Issues in Pharmacy and Medical Sciences

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Selection of Relevant Bacterial Strains for Novel Therapeutic Testing: a Guidance Document for Priority Cystic Fibrosis Lung Pathogens

Mahenthiralingam

Weiser

Floto

et al. 2022

Curr Clin Micro Rpt

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Purpose of Review People with cystic fibrosis (CF) suffer chronic lung infections with a range of antimicrobial-resistant bacterial pathogens. There is an urgent need for researchers to develop novel anti-infectives to treat these problematic infections, but how can we select bacterial strains which are relevant for robust testing and comparative research? Recent Findings Pseudomonas aeruginosa, Burkholderia cepacia complex and Burkholderia gladioli, Mycobacterium abscessus complex, Staphylococcus aureus, Haemophilus influenza, and several multidrug-resistant Gram-negative species were selected as key CF infections that urgently require new therapeutics. Reference isolates and strain panels were identified, and a summary of the known genotypic diversity of each pathogen was provided. Summary Here, we summarise the current strain resources available for priority CF bacterial pathogens and highlight systematic selection criteria that researchers can use to select strains for use in therapeutic testing.

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Microbial Epidemiology of the Cystic Fibrosis Airways: Past, Present, and Future

Thornton

Parkins

2023

Semin Respir Crit Care Med

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Progressive obstructive lung disease secondary to chronic airway infection, coupled with impaired host immunity, is the leading cause of morbidity and mortality in cystic fibrosis (CF). Classical pathogens found in the airways of persons with CF (pwCF) include Pseudomonas aeruginosa, Staphylococcus aureus, the Burkholderia cepacia complex, Achromobacter species, and Haemophilus influenzae. While traditional respiratory-tract surveillance culturing has focused on this limited range of pathogens, the use of both comprehensive culture and culture-independent molecular approaches have demonstrated complex highly personalized microbial communities. Loss of bacterial community diversity and richness, counteracted with relative increases in dominant taxa by traditional CF pathogens such as Burkholderia or Pseudomonas, have long been considered the hallmark of disease progression. Acquisition of these classic pathogens is viewed as a harbinger of advanced disease and postulated to be driven in part by recurrent and frequent antibiotic exposure driven by frequent acute pulmonary exacerbations. Recently, CF transmembrane conductance regulator (CFTR) modulators, small molecules designed to potentiate or restore diminished protein levels/function, have been successfully developed and have profoundly influenced disease course. Despite the multitude of clinical benefits, structural lung damage and consequent chronic airway infection persist in pwCF. In this article, we review the microbial epidemiology of pwCF, focus on our evolving understanding of these infections in the era of modulators, and identify future challenges in infection surveillance and clinical management.

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Haemophilus influenzae and Haemophilus parainfluenza in Cystic Fibrosis: 15 Years Experience

Cited by 8 publications

References 19 publications

Phenotypic diversity of Haemophilus influenzae and Haemophilus parainfluenzae isolates depending on origin and health condition

Phenotypic diversity of Haemophilus influenzae and Haemophilus parainfluenzae isolates depending on origin and health condition

Selection of Relevant Bacterial Strains for Novel Therapeutic Testing: a Guidance Document for Priority Cystic Fibrosis Lung Pathogens

Microbial Epidemiology of the Cystic Fibrosis Airways: Past, Present, and Future

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