Haemophilia and Exercise

Souza, Jéssica Cardoso de; Simões, Herbert Gustavo; Campbell, Carmen Silvia Grubert; Pontes, Francisco Luciano; Boullosa, Daniel; Prestes, Jonato

doi:10.1055/s-0031-1286292

Cited by 42 publications

(68 citation statements)

References 21 publications

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“…Seven reviews reported data regarding disease severity 6,8,[21][22][23][24]28 ; In three of them, no data related to the age range of the participants were reported.…”

Section: Populationmentioning

confidence: 99%

Effects of exercise in people with haemophilia: An umbrella review of systematic reviews and meta‐analyses

2019

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Haemophilia is a genetic X-linked congenital haemorrhagic disorder characterized by a deficiency in the production of coagulation factors VIII and IX corresponding to haemophilia types A and B, respectively. 1,2 Although rare, with a frequency of 1 in 10 000 births, haemophilia can be found in about 400 000 people worldwide. 3 Approximately 85% of haemorrhagic episodes occur in the musculoskeletal system, hemarthroses and intramuscular haematomas, resulting in the main complications of haemophilia: pain, muscle atrophy and functional limitations that, in the long term, directly affect the performance of activities of daily living. 4,5 As a result, people with haemophilia (PWH) experience a more sedentary lifestyle, with lower muscle strength, aerobic and anaerobic endurance, and proprioception compared with healthy individuals. 6,7 A few decades ago, exercise was contraindicated for PWH due to low clotting factor concentrations and the high risk of bleeding.However, with the advent of concentrates for coagulation factor replacement as a form of treatment and prophylaxis to haemorrhages, Abstract Introduction: There is considerable evidence to indicate that exercise can have a positive impact on the treatment of people with haemophilia (PWH). However, there is a requirement for in-depth and comprehensive studies.Aim: This study aimed to analyse the evidence regarding the effects of exercise in PWH through an umbrella review of existing systematic reviews and meta-analyses.The secondary objective was to analyse the quality of the evidence.Methods: This umbrella review followed the PRISMA guidelines and was documented in the PROSPERO registry (CRD42019140785). We searched the PubMed, Web of Science, SPORTDiscus, Scopus, CINAHL and Cochrane Library databases.The methodological quality of the systematic reviews was assessed using AMSTAR 2.Results: Out of a total of 1030 systematic reviews, 10 fulfilled the criteria. Only one study was classified as high quality, and half of the selected studies were classified as low or critically low quality according to AMSTAR 2. Furthermore, most reviews investigated the effects of strength training and aquatic training, with positive results associated with low adverse events. Range of motion, strength and pain were the most investigated variables. All reviews showed overlapping studies. Conclusion:Exercise is an effective way to treat haemophilia and has a low incidence of related adverse events. However, caution is needed in the interpretation of the results due to half of the selected reviews showed low or critically low quality and only one have high quality. K E Y W O R D Sbleeding disorders, evidence-based practice, exercise, haemophilia, haemophilic arthropathy | 929 SIQUEIRA Et Al.

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“…Seven reviews reported data regarding disease severity 6,8,[21][22][23][24]28 ; In three of them, no data related to the age range of the participants were reported.…”

Section: Populationmentioning

confidence: 99%

Effects of exercise in people with haemophilia: An umbrella review of systematic reviews and meta‐analyses

2019

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“…Patients with haemophilia are advised to avoid high impact contact sports such as rugby,2 although physical exercise is known to be of benefit to their general health, bone density and joint stability 3 4. The role of police officer is confrontational, physical and analogous to a contact sport.…”

Section: Discussionmentioning

confidence: 99%

Recruitment of a candidate with haemophilia B as a special constable in the metropolitan police service

Levene

Mathias

2014

BMJ Case Reports

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“…66,67 This is especially important for teens and young adults. 66,67 This is especially important for teens and young adults.…”

Section: General Considerations Throughout the Lifespanmentioning

confidence: 99%

Optimizing bleed prevention throughout the lifespan: Womb to Tomb

Gupta

Shapiro

2018

Haemophilia

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The focus of care providers, patients and families is the ability to tailor care for persons with haemophilia (PWH) across the lifespan. Care requires knowledge of the bleeding disorder and age-related complications, risk of therapeutic interventions, and evaluation of individual characteristics that contribute to outcomes. The ultimate goal is to live a normal life without the burden of bleeding, for PWH and carriers. A wide range of therapeutic options is required to achieve personalized care. Over the last decade, substantial therapeutic advantages have been achieved in the treatment of haemophilia that include the development of a robust array of factor concentrates, novel haemostatic agents, and increased knowledge and awareness of disease associated outcomes and risk factors. Significant strides on the road to accessible gene therapy have been realized. This increased range of therapeutic modalities provides options for development and implementation of care plans for each patient at each stage of life that are more flexible compared to prior care regimens. Paradigms for management of haemophilia are changing. As a community, we must work together to use these resources wisely, to learn from outcomes with new therapies and diagnostic tools, to assure all patients can achieve improved care and outcomes regardless of disease state or country of origin.

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Haemophilia and Exercise

Cited by 42 publications

References 21 publications

Effects of exercise in people with haemophilia: An umbrella review of systematic reviews and meta‐analyses

Effects of exercise in people with haemophilia: An umbrella review of systematic reviews and meta‐analyses

Recruitment of a candidate with haemophilia B as a special constable in the metropolitan police service

Optimizing bleed prevention throughout the lifespan: Womb to Tomb

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