Haemolytic uremic syndrome following fire ant bites

Lee, Yi‐Che; Wang, Jyh-Seng; Shiang, Jeng-Chuan; Tsai, Ming-Kai; Deng, Kai-Tai; Chang, Min-Yu; Wang, Hsi-Hao; Ho, Li-Chun; Chen, Yi-Ting; Hung, Shih-Yuan

doi:10.1186/1471-2369-15-5

Cited by 13 publications

(8 citation statements)

References 19 publications

(18 reference statements)

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“…SW is characterized by the presence of a lucent zone in the lamina rara interna and it is the most frequent glomerular lesion attributed to endothelial damage [ 17 ]. SW has been reported in human cases of endothelial damage such as transplant glomerulopathy, thrombotic microangiopathy, or hemolytic uremic syndrome, in which evolving chronicity is occasionally accompanied by segmental glomerular sclerosis [ 11 , 16 , 19 , 26 ]. Therefore, it is quite conceivable that podocyte and glomerular endothelial injury are involved in the development of FSGS.…”

Section: Introductionmentioning

confidence: 99%

Podocyte and endothelial injury in focal segmental glomerulosclerosis: an ultrastructural analysis

et al. 2015

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Podocyte injury contributes to the development of focal segmental glomerulosclerosis (FSGS). Endocapillary hypercellularity, which is one of the pathological characteristics of FSGS, suggests that glomerular endothelial injury may also be involved in the pathogenesis of FSGS. In electron micrographs of patients with FSGS (n = 43), we conducted morphometric measurements of foot process width (FPW) and podocyte detachment (PD) as markers of podocyte injury and subendothelial widening (SW) of the glomerular basement membrane as a marker of endothelial injury and compared them to those in patients with minimal change nephrotic syndrome (MCNS; n = 11) and control kidney donors (n = 5). Associations between ultrastructural and clinical parameters were analyzed according to the FSGS variants defined by the Columbia classification. FPW was significantly higher in the FSGS group than that in the MCNS and control groups, particularly in the collapsing, tip, and cellular variants of FSGS. Percentage of glomerular basement membrane (GBM) length showing PD and SW was significantly increased in the FSGS group, especially in the collapsing, cellular, and not otherwise specified variants. In FSGS, FPW was inversely correlated with disease duration, but not with proteinuria. Finally, the percentage of GBM length with SW significantly correlated with clinical parameters indicative of poor prognosis, such as lower remission rate and lower estimated glomerular filtration rate at the final observation. Quantitative measurement of podocyte and endothelial injury by electron microscopy might be useful for evaluating histological activity and predicting prognosis in FSGS.Electronic supplementary materialThe online version of this article (doi:10.1007/s00428-015-1821-9) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Podocyte and endothelial injury in focal segmental glomerulosclerosis: an ultrastructural analysis

et al. 2015

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“…Some patients (17 to 56%) develop a large local reaction consisting of an extremely large and pruritic lesion persisting for up to 72 h [13]. IgE-mediated severe allergic reactions following IFA stings are well documented and sometimes even lead to severe endorgan damage, including rhabdomyolysis, renal failure, and neurotoxic effects, which can also be induced by direct toxic effects of multiple ant stings [14][15][16][17].…”

Section: Yellow Fever Mosquito (Aedes Aegypti)mentioning

confidence: 99%

Part I: Insect stings and bites—Beyond the realm of bee and wasp allergies

et al. 2022

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Summary Background Insects are a very diverse group of animals and valuable members of any ecosystem. Allergies to bees and wasps (order: Hymenoptera) are well known in Europe. Allergies, toxicities, and the spread of diseases by other insects are also possible but quite frequently are not diagnosed. Sources A MEDLINE search on allergy caused by stinging and biting insects apart from bees and wasps was conducted. All relevant articles were evaluated, and a selection of relevant publications and cases from our outpatient units are used to illustrate our arguments. Content and implications Allergies to insects following bites and stings are common. Ant stings, mainly from imported fire ants, frequently lead to severe anaphylaxis, and their venom can elicit systemic toxic effects. Stings and bites of various other ant species can also lead to severe allergic reactions. Mosquito stings and horsefly or other Diptera stings may elicit severe local and IgE-mediated systemic reactions. True bugs (Hemiptera) are hematophagous insects and can also cause severe allergic reactions, in addition to being feared for transmitting diseases.

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“…Later surveys over the period [2005][2006][2007][2008][2009][2010][2011] showed that more than one-third of people in infested areas had been stung and again nearly 1% of victims experienced severe allergic reactions with some deaths recorded as a result (Xu et al 2012). In Taiwan, several cases of severe reactions to stings have been reported (Chen et al 2005;Lee et al 2014).…”

Section: Hea Lthmentioning

confidence: 99%

Red Imported Fire Ant in Australia: What if we lose the war?

Wylie¹,

Janssen-May²

2016

Eco Management Restoration

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Summary In Australia, a national eradication programme for the Red Imported Fire Ant (Solenopsis invicta Buren), one of the world's most invasive species, has been in operation since 2001 when the pest was first detected in Brisbane, Queensland. Since that time, four separate incursions of this ant have been successfully eradicated from this country, but the main Brisbane population remains. Cost‐benefit analyses already conducted put the likely impact of Red Imported Fire Ant in Australia, if not eradicated, at between A$8.5 and A$45 billion. Despite this, ongoing funding for the eradication programme is not assured. A recent external review has concluded that it remains technically feasible, cost beneficial and in the national interest to eradicate. In support of previous analyses, our study highlights some of the potential impacts of Red Imported Fire Ant in Australia in more detail and provides case examples. Results show that adverse impacts are likely in most sectors of the economy, and will be felt not only by agricultural industries, but also the building and construction, tourism, electrical and communications industries. In addition to industry effects, there will also be negative impacts on public health and lifestyle, the environment and infrastructure such as main roads, airports and schools. Our estimates of potential cost impacts in the case examples where extrapolation was possible exceed A$1.65 billion/year and support previous predictions. We conclude that increased spending is justified to avert ‘invasion debt’ – the future cost of battling pests that escape today. This is a war that Australia cannot afford to lose.

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Haemolytic uremic syndrome following fire ant bites

Cited by 13 publications

References 19 publications

Podocyte and endothelial injury in focal segmental glomerulosclerosis: an ultrastructural analysis

Podocyte and endothelial injury in focal segmental glomerulosclerosis: an ultrastructural analysis

Part I: Insect stings and bites—Beyond the realm of bee and wasp allergies

Red Imported Fire Ant in Australia: What if we lose the war?

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