Haemolytic transfusion reaction in a Gy(a‐) patient with anti‐Gy^a: a case report

Anti‐Gya and pregnancy

“…patient with anti-Gy a antibodies who repeatedly experienced mild haemolytic transfusion reactions. 1 The Gy a (Gregory) antigen, which is part of the Dombrock system, has extremely high frequency in all populations, so it is practically impossible to obtain blood from Gy(a-) donors. Therefore, Dwight et al transfused their patient with Gy (a+) blood that was serologically incompatible, and by reporting their experience, they helped expand our rather scarce knowledge on the clinical significance of anti-Gy a , which is still unclear.…”

“…Therefore, Dwight et al transfused their patient with Gy (a+) blood that was serologically incompatible, and by reporting their experience, they helped expand our rather scarce knowledge on the clinical significance of anti-Gy a , which is still unclear. 1 In the past, we encountered anti-Gy a in a pregnant women, and we faced exactly the same lack of clarity regarding the significance of this antibody. As we believe that the transfusion relevance of anti-Gy a is still incompletely understood, we like to share our experience.…”

“…[5][6][7] In addition, the fact that Mrs. Gregory, in whom the first example of this antibody specificity was detected, 4 had two uncomplicated pregnancies suggests that anti-Gy a does not cause HDFN. However, in a blood transfusion setting, the clinical significance of anti-Gy a remains more controversial: some authors have observed no or only mild haemolytic transfusion reactions, 1,[8][9][10] whereas others consider anti-Gy a a serious antibody. 7,[11][12][13]…”

Immunohaematology: the core of laboratory transfusion practice

“…describe a haemolytic transfusion reaction due to anti‐Gy a antibodies directed at the Gregory (Gy a ) blood group antigen, which has been assigned to the Dombrock blood group system. The Gy(a‐) phenotype represents the null allele for the Dombrock antigen, and the case report describes the investigation and management of a patient with anti‐Gy a when Gy(a‐) units could not be sourced (Dwight et al, ).…”