Haemolytic activities of plant saponins and adjuvants. Effect of Periandra mediterranea saponin on the humoral response to the FML antigen of Leishmania donovani

Santos, Wania Renata dos; Bernardo, Robson Ronney; Pecanha, L. M. T.; Palatnik, Marcos; Parente, José Paz; Palatnik-de-Sousa, Clarisa B.

doi:10.1016/s0264-410x(96)00292-7

Cited by 87 publications

(39 citation statements)

References 24 publications

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“…This assay indicates that the acid hydrolyses of CE was effective, since that HEAS extract counting sapogenins showed minor hemolytic percentage (69.9 maximum) in comparison to CE (102 maximum) which is very rich in saponins. Santos et al, 1997 reported that steroidal saponins of A. sisalana were more hemolytic in comparison with triterpenoid saponins. However in our research, we have made an acid hydrolysis aiming to reduce hemolytic action by the removal of glicosidic moiety.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and analgesic potential of hydrolyzed extract of Agave sisalana Perrine ex Engelm., Asparagaceae

Dunder¹,

Quaglio

Maciel

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Potencial anti-inflamatório e analgésico do extrato hidrolisado deUnitermos: Agave sisalana, Asparagaceae, Agavoideae, hemolítica anti-inflamatória, analgesia. ABSTRACT:The hemolytic, anti-inflammatory and antinociceptive properties from hydrolyzed extract Agave sisalana Perrine ex Engelm., Asparagaceae (HEAS) was evaluated on classic inflammation models. Male Swiss mice and male Wistars rats received HEAS (500 mg/kg) in two administration p.o. and i.p. in saline solution 0.9%. The acid hydrolysis inhibited the hemolytic action of saponins due to the retreat of side chain sugar. The treatment of the ear induced oedema by xylene with HEAS significantly reduced in two routes 13±1.5 and 10±0.63 mg, respectively, p.o. and i.p., in comparison with controls 27±1.5 saline and 13.5±1.2 AAS. The HEAS also diminished edema induced by carrageenin 43±1.58 mg (p.o.) and 17±1.26 mg (i.p.), when compared with control groups 52±1.58 mg (saline) and 10.05±1.58 (indomethacin). HEAS showed analgesic effects in abdominal constrictions 30.7% (p.o.), 88.7% (i.p.) comparable to that produced by (AAS) 70.6%. However in granuloma cotton pellet a chronic model of inflammation just the i.p. pathway decreased granulomatous tissue (20.4±1.32 mg) compared with controls 30.5±2.53 mg (saline) and 20.2±2.18 mg (dexamethasone). These data suggest that HEAS has anti-inflammatory and analgesic activity on acute and chronic processes.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and analgesic potential of hydrolyzed extract of Agave sisalana Perrine ex Engelm., Asparagaceae

Dunder¹,

Quaglio

Maciel

et al. 2010

Rev. bras. farmacogn.

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“…Asadi et al (28) showed that the hydroalcoholic extracts of Stachys lavandulifolia and Mespilus germanica have antileishmanial activities. Some studies have also shown that these extracts are suitable adjuvants in vaccination against Leishmania species (29,30). Recently, invivo studies have revealed that alcoholic extract of Hedera helix and ethanol extract of Peganum harmala exert antileishmanial effects on L. major (31,32).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antileishmanial Activity of Falcaria vulgaris Fractions on Leishmania major

AliEskandarian

HamedJafari

Asghari

et al. 2017

Jundishapur J Nat Pharm Prod

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“…Some authors found that a few plants can be used as an adjuvant in vaccination against Leishmania spp. (Santos et al 1997;Kaur et al 2014). Recent studies showed that the extracts of Hedera helix and Peganum harmala have potent antileishmanial effects (Khoshzaban et al 2014;Hooshyar et al 2014).…”

Section: Discussionmentioning

confidence: 99%

In vitro anti-leishmanial activity of Satureja hortensis and Artemisia dracunculus extracts on Leishmania major promastigotes

et al. 2016

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Cutaneous leishmaniasis is one of the important skin diseases with diverse clinical manifestations. With an incidence of 0.7-1.3 million cases annually, this disease is often reported from six countries, including Iran. Accordingly, the purpose of this study was to evaluate the antileishmanial effect of the three plant hydroalcoholic extracts including fleawort (Plantago psyllium L.), savory (Satureja hortensis L.) and tarragon (Artemisia dracunculus L.) on Leishmania major promastigotes. The hydroalcoholic extract from each plant was extracted and its anti-leishmanial effect was evaluated in different concentrations (100-1000 lg/ml) and at various hours (24, 48 and 72 h). Savory herb inhibitory concentration 50 % (IC 50 ) at 24, 48 and 72 h was 790.81, 398.11 and 298.42 lg/ml, respectively. In addition, tarragon herb IC 50 at 24, 48 and 72 h was 962.03, 688.36 and 585.51 lg/ml, respectively. Moreover, the fleawort extract was showed the lowest effect, considering that its effect at the concentration of 1000 lg/ml was 48 % after 72 h (P [ 0.05). Furthermore, the statistical analysis showed a significant difference for interaction between concentration and time regarding the tarragon and savory extracts with a P value of lower than 0.05. According to the results, the anti-leishmanial effect of the tarragon and savory extracts may make it possible to use them in the treatment of cutaneous leishmaniasis as a complementary or alternative therapy; however, further studies are necessary and should be evaluated in cell culture and in vivo conditions to confirm it.

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Haemolytic activities of plant saponins and adjuvants. Effect of Periandra mediterranea saponin on the humoral response to the FML antigen of Leishmania donovani

Cited by 87 publications

References 24 publications

Anti-inflammatory and analgesic potential of hydrolyzed extract of Agave sisalana Perrine ex Engelm., Asparagaceae

Anti-inflammatory and analgesic potential of hydrolyzed extract of Agave sisalana Perrine ex Engelm., Asparagaceae

In Vitro Antileishmanial Activity of Falcaria vulgaris Fractions on Leishmania major

In vitro anti-leishmanial activity of Satureja hortensis and Artemisia dracunculus extracts on Leishmania major promastigotes

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