“…Volume status and BP regulation are intimately correlated [ 37 ]. Earlier reports have shown overhydration and increased ECW volume in primary aldosteronism vs. essential hypertension [ 8 – 12 ], whereas BP reduction has been reported to correlate with plasma volume contraction in primary aldosteronism [ 38 ]. We observed ∼1 l ECW excess in the primary aldosteronism patients, which was normalized by adrenalectomy and spironolactone-based treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Early investigations using radiolabelled tracers in small patient groups indicated that aldosterone excess is characterized by volume overload [8,9]. Recent studies utilizing bioimpedance have confirmed extracellular fluid overload in primary aldosteronism patients [10][11][12]. Aldosterone excess increases growth factors and collagen accumulation in the arteries [6,7].…”
Objectives:
We examined haemodynamics, focusing on volume balance and forward and backward wave amplitudes, before and after 2.8 years of targeted treatment of primary aldosteronism. Patients with essential hypertension and normotensive individuals were examined for comparison (n = 40 in each group).
Methods:
Recordings were performed using radial artery pulse wave analysis and whole-body impedance cardiography. Unilateral aldosteronism was treated with adrenalectomy (n = 20), bilateral aldosteronism with spironolactone-based medication (n = 20), and essential hypertension with standard antihypertensive agents.
Results:
Aortic SBP and DBP, forward and backward wave amplitudes, and systemic vascular resistance were equally elevated in primary aldosteronism and essential hypertension. All these haemodynamic variables were similarly reduced by the treatments. Primary aldosteronism presented with 1 litre (∼10%) extracellular water excess (P < 0.001) versus the other groups, and this excess was normalized by treatment. Initial pulse wave velocity (PWV) was similarly increased in primary aldosteronism and essential hypertension, but final values remained higher in primary aldosteronism (P < 0.001). In regression analyses, significant explanatory factors for treatment-induced forward wave amplitude reduction were decreased systemic vascular resistance (β = 0.380) and reduced extracellular water volume (β = 0.183). Explanatory factors for backward wave amplitude reduction were changes in forward wave amplitude (β = 0.599), heart rate (β = −0.427), and PWV (β = 0.252).
Conclusion:
Compared with essential hypertension, the principal haemodynamic difference in primary aldosteronism was higher volume load. Volume excess elevated forward wave amplitude, which was subsequently reduced by targeted treatment of primary aldosteronism, along with normalization of volume load. We propose that incorporating extracellular water evaluation alongside routine diagnostics could enhance the identification and diagnosis of primary aldosteronism.
“…Volume status and BP regulation are intimately correlated [ 37 ]. Earlier reports have shown overhydration and increased ECW volume in primary aldosteronism vs. essential hypertension [ 8 – 12 ], whereas BP reduction has been reported to correlate with plasma volume contraction in primary aldosteronism [ 38 ]. We observed ∼1 l ECW excess in the primary aldosteronism patients, which was normalized by adrenalectomy and spironolactone-based treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Early investigations using radiolabelled tracers in small patient groups indicated that aldosterone excess is characterized by volume overload [8,9]. Recent studies utilizing bioimpedance have confirmed extracellular fluid overload in primary aldosteronism patients [10][11][12]. Aldosterone excess increases growth factors and collagen accumulation in the arteries [6,7].…”
Objectives:
We examined haemodynamics, focusing on volume balance and forward and backward wave amplitudes, before and after 2.8 years of targeted treatment of primary aldosteronism. Patients with essential hypertension and normotensive individuals were examined for comparison (n = 40 in each group).
Methods:
Recordings were performed using radial artery pulse wave analysis and whole-body impedance cardiography. Unilateral aldosteronism was treated with adrenalectomy (n = 20), bilateral aldosteronism with spironolactone-based medication (n = 20), and essential hypertension with standard antihypertensive agents.
Results:
Aortic SBP and DBP, forward and backward wave amplitudes, and systemic vascular resistance were equally elevated in primary aldosteronism and essential hypertension. All these haemodynamic variables were similarly reduced by the treatments. Primary aldosteronism presented with 1 litre (∼10%) extracellular water excess (P < 0.001) versus the other groups, and this excess was normalized by treatment. Initial pulse wave velocity (PWV) was similarly increased in primary aldosteronism and essential hypertension, but final values remained higher in primary aldosteronism (P < 0.001). In regression analyses, significant explanatory factors for treatment-induced forward wave amplitude reduction were decreased systemic vascular resistance (β = 0.380) and reduced extracellular water volume (β = 0.183). Explanatory factors for backward wave amplitude reduction were changes in forward wave amplitude (β = 0.599), heart rate (β = −0.427), and PWV (β = 0.252).
Conclusion:
Compared with essential hypertension, the principal haemodynamic difference in primary aldosteronism was higher volume load. Volume excess elevated forward wave amplitude, which was subsequently reduced by targeted treatment of primary aldosteronism, along with normalization of volume load. We propose that incorporating extracellular water evaluation alongside routine diagnostics could enhance the identification and diagnosis of primary aldosteronism.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.