Haemodynamic studies after repair of ventricular septal defect.

Gotsman, Mervyn S.; Beck, Walter; Barnard, C. N.; Schrire, V.

doi:10.1136/hrt.31.1.63

Cited by 18 publications

(5 citation statements)

References 44 publications

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“…According to their own classification scheme using defect size and the ratio of pulmonary systolic pressure to systemic systolic pressure, they found that 1-year post-surgery pulmonary artery pressures fell in all patients but that there was little change in pulmonary-to-systemic vascular resistance in patients with Type 1B (small defect, shunt 10-40%), Type 1C ("slightly larger" defect, shunt > 40%), or Type 2 (moderate-sized defect, shunt 40-80%), compared to a variable response in Type 3A patients (large defect, shunt > 40%). 30 Soon thereafter, Maron et al studied 11 patients aged 11-40 years at the time of ventricular septal defect repair. These authors performed exercise studies 3-15 years after ventricular septal defect closure and found that during intense exercise, cardiac output was below normal in five patients and that two patients had an abnormally elevated mean pulmonary artery pressure.…”

Section: Peri-operative and Long-term Outcomesmentioning

confidence: 99%

Outcomes of infants and children undergoing surgical repair of ventricular septal defect: a review of the literature and implications for research with an emphasis on pulmonary artery hypertension

Palladino-Davis

Davis

2020

Cardiol Young

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Background:Pulmonary vascular disease resulting from CHDs may be the most preventable cause of pulmonary artery hypertension worldwide. Many children in developing countries still do not have access to early closure of clinically significant defects, and the long-term outcomes after corrective surgery remain unclear. Focused on long-term results after isolated ventricular septal defect repair, our review sought to determine the most effective medical therapy for the pre-operative management of elevated left-to-right shunts in patients with an isolated ventricular septal defect.Methods:We identified articles specific to the surgical repair of isolated ventricular septal defects. Specific parameters included the pathophysiology and pre-operative medical management of pulmonary over-circulation and outcomes.Results:Studies most commonly focused on histologic changes to the pulmonary vasculature and levels of thromboxanes, prostaglandins, nitric oxide, endothelin, and matrix metalloproteinases. Only 2/44 studies mentioned targeted pharmacologic management to any of these systems related to ventricular septal defect repair; no study offered evidence-based guidelines to manage pulmonary over-circulation with ventricular septal defects. Most studies with long-term data indicated a measurable frequency of pulmonary artery hypertension or diminished exercise capacity late after ventricular septal defect repair.Conclusion:Long-term pulmonary vascular and respiratory changes can occur in children after ventricular septal defect repair. Research should be directed at providing an evidenced-based approach to the medical management of infants and children with ventricular septal defects (and naturally all CHDs) to minimise consequences of pulmonary artery hypertension, particularly as defect repair may occur late in underprivileged societies.

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Section: Peri-operative and Long-term Outcomesmentioning

confidence: 99%

Outcomes of infants and children undergoing surgical repair of ventricular septal defect: a review of the literature and implications for research with an emphasis on pulmonary artery hypertension

Palladino-Davis

Davis

2020

Cardiol Young

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“…Literatürün gözden geçi-rilmesi ile, olguların postoperatif hemodinamik verilerinin saptanmasında farklı kriterler kullanıldığı gö-rülmüştür (4,8,(10)(11)(12)(13)(14)(15). Bazı çalışmalarda hastalar preoperatif ve postoperatif Rp/Rs oranı ile, diğerle-rinde ise pulmoner arter/aorta basıncı oranı ile izlenmektedir (4,8).…”

Section: Bulgularunclassified

“…Bazı çalışmalarda hastalar preoperatif ve postoperatif Rp/Rs oranı ile, diğerle-rinde ise pulmoner arter/aorta basıncı oranı ile izlenmektedir (4,8). Araştırmaların çoğunda postoperatif kateterizasyonda sol-sağ şantın azalması sonucu, pulmoner arter basıncının normal değere inmemekle birlikte, düştüğü bildirilmiştir (10)(11)(12)(13)(14)(15). Defektin onarımından sonra pulmoner hipertansiyonun düzelmesi, operasyon yaşı, sol-sağ şantın miktarı ve vasküler değişikliklerin derecesi ile yakından ilişkili-dir (8).…”

Section: Bulgularunclassified

Pulmoner Vaskuler Rezi̇stansi Yüksek Ventrikuler Septal Defektli̇ Hastalarin Prognozu

Atalay¹,

Dilek²,

Uysalel³

et al. 1996

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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“…Zwei Drittel aller Operierten, welche den Eingriff überlebten, hatten einen Rückgang des Lungenhochdruckes unter 50 % des Systemdrukkes. Nach Untersuchungen von K. A. Hallidie-Smith (20) und anderen Autoren (5,19) ist bei diesen späterhin mit einem weiteren Druckrückgang zu rechnen.…”

Section: Diskussionunclassified

Über den Einfluß des pulmonalen Hochdrucks auf die Ergebnisse des operativen Verschlusses von Ventrikelseptumdefekten*

Brunner¹,

Heisig²,

Vivie³

et al. 1972

Thorac cardiovasc Surg

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Haemodynamic studies after repair of ventricular septal defect.

Cited by 18 publications

References 44 publications

Outcomes of infants and children undergoing surgical repair of ventricular septal defect: a review of the literature and implications for research with an emphasis on pulmonary artery hypertension

Outcomes of infants and children undergoing surgical repair of ventricular septal defect: a review of the literature and implications for research with an emphasis on pulmonary artery hypertension

Pulmoner Vaskuler Rezi̇stansi Yüksek Ventrikuler Septal Defektli̇ Hastalarin Prognozu

Über den Einfluß des pulmonalen Hochdrucks auf die Ergebnisse des operativen Verschlusses von Ventrikelseptumdefekten*

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