Haemodynamic evaluation of pulmonary hypertension

Chemla, Denis; Castelain, Vincent; Hervé, Philippe; Lecarpentier, Yves; Brimioulle, Serge

doi:10.1183/09031936.02.00068002

Cited by 302 publications

(220 citation statements)

References 135 publications

(196 reference statements)

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“…It has been shown that those individuals with the positive criteria at pulmonary vasoreactivity test show lower basal hemodynamic impairment, with vasoconstriction predominating in these patients when compared to the remodeling phenomenon 21,22 . These patients may have sustained hemodynamic and clinical response to the introduction of nonselective vasodilators to pulmonary circulation, with improved prognosis, specifically with calcium channel blockers, which are accessible and affordable drugs 9,23,24 .…”

Section: Discussionmentioning

confidence: 99%

Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Japyassú¹,

Mendes²,

Bandeira³

et al. 2012

Arq. Bras. Cardiol.

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Section: Discussionmentioning

confidence: 99%

Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Japyassú¹,

Mendes²,

Bandeira³

et al. 2012

Arq. Bras. Cardiol.

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“…Mean pulmonary arterial pressure (PAP) was figured out by the formula of 79-(0.45X pulmonary artery acceleration time) (13,14).…”

Section: Echocardiographymentioning

confidence: 99%

Effects of right ventricular dysfunction on exercise capacity and quality of life and associations with serum NT-proBNP levels in COPD: an observational study

Özdemirel¹,

Ulaşlı²,

Yetis³

et al. 2014

Anadolu Kardiyol Derg

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Objective: During the course of chronic obstructive pulmonary disease (COPD), pulmonary hypertension (PH) and right ventricular (RV) failure may develop due to elevated afterload of the RV. In those patients, exercise capacity is reduced due to pulmonary and cardiac limitations. We investigated relationships between serum N-terminal of proB-type natriuretic peptide (NT-proBNP) and RV functions with exercise capacity and quality of life in patients COPD.Methods: An observational case-control study was conducted. We enrolled 31 moderate and severe COPD patients, and 20 subjects without chronic diseases as control group. Parameters reflecting the right ventricular diastolic and systolic functions by echocardiography along with serum NT-proBNP levels were assessed. Cardiopulmonary exercise testing and Short Form-36 (SF-36) were applied. Results: Serum NT-proBNP levels were higher in COPD patients than control group (p=0.003). Serum NT-proBNP level was found to be related with pulmonary arterial pressure. Serum NT-proBNP levels were negatively correlated with anaerobic threshold oxygen uptake (AT VO 2 ) and peak oxygen uptake (PVO 2 ) values. Early ventricular filling velocity (Em) was lower in COPD patients. Em wave was significantly correlated with O 2 pulse. There was a positive relationship between tricuspid E/A ratio and VO 2 value at AT. SF-36 domains of physical functioning, general health and role limitation due to physical disorder were significantly correlated with AT VO 2 , PVO 2 and O 2 pulse. Conclusion: Exercise limitation may be predicted by assessment of right ventricule functions and NT-proBNP levels and exercise limitation impairs quality of life in COPD patients.

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“…Common findings in the evaluation of patients with PH include dilatation of the right heart chambers, right ventricular hypertrophy, paradoxical septal movement, and tricuspid insufficiency. (4)(5)(6)(7) According to some studies, (8,9) a large percentage of patients with CF present subclinical PH. The great phenotypic variability of the disease (10) justifies a systematic diagnostic approach to evaluate PH in a population of adolescent and adult patients in Brazil.…”

Section: Introductionmentioning

confidence: 99%

“…When the hypoxic state is prolonged, the pulmonary circulation suffers structural alterations collectively known as remodeling, characterized by hypertrophy and hyperplasia of the arterial media, as well as by muscle fibers in the peripheral vessels. (3)(4)(5) The diagnostic procedure that is the most accurate in identifying the onset of PH is heart catheterization, and the most sensitive noninvasive technique for the early detection and monitoring of PH is Doppler echocardiography. (4,5) Echocardiography allows us to identify and quantify PH, as well as to determine its variability and the repercussions for the right heart chambers.…”

Section: Introductionmentioning

confidence: 99%

“…(3)(4)(5) The diagnostic procedure that is the most accurate in identifying the onset of PH is heart catheterization, and the most sensitive noninvasive technique for the early detection and monitoring of PH is Doppler echocardiography. (4,5) Echocardiography allows us to identify and quantify PH, as well as to determine its variability and the repercussions for the right heart chambers. In addition, echocardiography allows serial evaluations after therapeutic interventions.…”

Section: Introductionmentioning

confidence: 99%

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Prevalência de hipertensão pulmonar avaliada por ecocardiografia Doppler em uma população de pacientes adolescentes e adultos com fibrose cística

Rovedder¹,

Ziegler²,

Pinotti³

et al. 2008

J. bras. pneumol.

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Objective: To determine the prevalence of pulmonary hypertension (PH) in patients with cystic fibrosis (CF), to compare clinical characteristics, radiographic scores, pulmonary function, and echocardiographic parameters in patients with and without PH, and to correlate echocardiographic findings with clinical characteristics, radiographic scores, and pulmonary function. Methods: This was a prospective, cross-sectional study involving clinically stable patients (aged 16 or older) enrolled in an adult CF program. The patients were submitted to clinical evaluation, Doppler echocardiography, pulmonary function tests, and chest X-rays. Results: Tricuspid regurgitant jet velocity (TRV) was obtained in 37 of the 40 patients studied. The prevalence of PH was 49% with a TRV cut-off of 2.5 m/s (18 patients) and 30% with a TRV cut-off of 2.8 m/s (11 patients). Peripheral oxygen saturation (SpO 2 ) at rest, clinical score, forced expiratory volume in one second (FEV 1 ), and forced vital capacity (FVC) were significantly lower in the group with PH. The TRV was found to correlate significantly with SpO 2 at rest (p < 0.001), clinical score (p < 0.001), radiographic score (p = 0.030), FEV 1 in liters (p < 0.001) and in % of predicted (p < 0.001), and FCV in liters (p = 0.008) and in % of predicted (p = 0.001). The single best predictor of TRV was SpO 2 at rest (p < 0.001). Conclusion: The high prevalence of PH in the CF patients studied suggests that PH should be considered in the evaluation and follow-up treatment of such patients. The best predictor of PH was SpO 2 at rest.

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Haemodynamic evaluation of pulmonary hypertension

Cited by 302 publications

References 135 publications

Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Effects of right ventricular dysfunction on exercise capacity and quality of life and associations with serum NT-proBNP levels in COPD: an observational study

Prevalência de hipertensão pulmonar avaliada por ecocardiografia Doppler em uma população de pacientes adolescentes e adultos com fibrose cística

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