L APAROSCOPY is ''the golden standard'' in treating symptomatic gallstones. Because the postoperative benefits are superior to open cholecystectomy, laparoscopy is today also used in patients with underlying diseases. To be able to treat this challenging patient population, we should be aware of physiological alterations caused by carbon dioxide (CO 2) insufflation and elevated intra-abdominal pressure (IAP). It is now commonly accepted that pneumoperitoneum causes intraoperative adverse cardiovascular, respiratory and renal effects. Some of these effects are related to CO 2 and some to elevated IAP. CO 2 is the preferred gas for the creation of pneumoperitoneum because it is inexpensive, highly soluble, chemically stable, rapidly eliminated, physically inert, suppresses combustion and also provides fairly good illumination. CO 2 is a normal product of human metabolism and at physiological levels non-toxic.