Haemodynamic Effects of Long-Term Prazosin Therapy in Patients with Congestive Heart Failure

Kuck, K. H.; Hanrath, Peter; Zenke, A.; Mathey, D; Bleifeld, W.

doi:10.1097/00005344-198002003-00015

Cited by 10 publications

(2 citation statements)

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“…Oral vasodilators (Hindman et al, 1980;Kirkin & Pitt, 1981;Kuck et al, 1980) such as hydralazine and prazosin are useful in this setting, however many cases of tachyphylaxis (Desch et al, 1979) have been reported and they are contra-indicated in hypotensive patients. Oral ,8-adrenoceptor agonists (Bourdillon et al, 1980;Kirkin & Pitt, 1981) such as prenalterol, pirbuterol and salbutamol may also be effective but they may increase heart rate and induce ventricular arrhythmias.…”

Section: Discussionmentioning

confidence: 99%

The effective plasma concentrations of sulmazol (AR‐L 115 BS) on haemodynamics in chronic heart failure.

Renard¹,

Jacobs²,

Mols³

et al. 1983

Brit J Clinical Pharma

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1 Sulmazol (AR-L 115 BS) is a new inotropic drug which has arterial and venous vasodilating properties. We used it in seven patients with severe refractory heart failure to determine the effective plasma concentration levels and the most effective bolus dose on haemodynamics. 2 The haemodynamic monitoring included a Swan-Ganz catheter in the pulmonary artery and a radial catheter. Haemodynamic measurements and plasma concentration determinations were performed before sulmazol injection and at 5, 10 and 30 min after a bolus of 0.25, 0.50, 0.75 mg/kg. 3 We observed a gradual increase in cardiac index and decrease in pulmonary wedge pressure when plasma concentration levels rose but the beneficial effects were mainly observed for sulmazol plasma concentrations above 1 ,ug/ml. A bolus injection of 0.75 mg/kg was effective in all cases: a significant increase of cardiac index (1.9 to 2.5 1 min-' m; P < 0.001) and a significant decrease in pulmonary wedge pressure (30 to 25 mm Hg; P < 0.005) and right atrial pressure (13 to 10 mm Hg, P < 0.01) were observed. 4 In these patients sulmazol improved the severely deteriorated left ventricular function without affecting heart rate and blood pressure.

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