Haemodynamic effects of haemorrhage during xenon anaesthesia in pigs

Abstract

Haemodynamic response to acute haemorrhage appeared faster with xenon/remifentanil than with isoflurane/remifentanil anaesthesia. In particular MAP decrease and short-term recovery were more marked with xenon (P<0.02). In the xenon group, volume replacement increased FAC compared with control and isoflurane (P<0.02).

Hemodynamic Parameters Change Earlier Than Tissue Oxygen Tension in Hemorrhage

“…Similar findings were reported in a study in which the heart rate of 22 pigs did not increase during fast withdrawal of 30 mL/kg blood, while a prolonged bleeding time resulted in a significant tachycardia [14]. Comparing the hemodynamic response with blood loss using either isoflurane or xenon anesthesia in 20 pigs, no tachycardia was found in the group anesthetized with isoflurane [15]. The parameter difference in pulse pressure is more sensitive to detect blood loss than other hemodynamic parameters such as MAP, CVP, cardiac output, or pulmonary artery pressure [10].…”

Combining xenon and mild therapeutic hypothermia preserves neurological function after prolonged cardiac arrest in pigs*

“…In hemodynamically unstable patients, furthermore, Xe preserves arterial pressures and heart-rate variability (8,44,45). CA often occurs as a manifestation of myocardial infarction, and patients successfully resuscitated from OHCA exhibit left-ventricular dysfunction as a result of myocardial stunning (46,47).…”

Ventilação mandatória intermitente sincronizada versus ventilação com suporte pressórico e volume garantido em coelhos induzidos à hemorragia aguda

“…Vet. Zootec., v.64, n.6, p.1555-1562, 2012 fracasso dos mecanismos compensatórios em resposta à hipotensão induzida neste estudo pode ser devido à vasodilatação e ao inotropismo negativo (Baurmet et al, 2005), que são induzidos pela maioria dos anestésicos, inclusive pelo propofol (Reves, 2000).…”