Haemodynamic Effects and Recovery Profile With Midazolam and Propofol as Coinduction Agents for Day Care Surgery

Kosam, Durga; Kujur, Shweta; Madhumita, Murthy

doi:10.14260/jemds/2018/801

Cited by 1 publication

(3 citation statements)

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“…In this article, we'll look at the pharmacology of midazolam and how it can be used as a coinduction agent. Imidazo benzodiazepine is a water soluble imidazo benzodiazepine [7][8][9][10]. Anxiolysis, sedation and anti-convulsant are only a few of the effects.…”

Section: Introductionmentioning

confidence: 99%

“…The inhibitory impact of g-aminobutyric acid is amplified when these receptors are activated (GABA). In physiological pH, midazolam is lipidsoluble and promptly enters the central nervous system [7,8] Fryer and Walser were the first to synthesize it in 1976 [7,9,10].…”

Section: Introductionmentioning

confidence: 99%

“…When it's in a solution with a pH higher than 4, the imidazole ring closes and it becomes much more lipid soluble, allowing it to enter nerve tissue more quickly. This helps to explain its quick onset of action and strong blood protein binding (up to 97 percent) [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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A Review on the use of Midazolam as a Co-induction Agent

Nigam

Verma

2021

JPRI

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The practice of delivering a small amount of sedative or another anesthetic drug to lessen the dose of induction agent necessary has been known as co-induction. In other terms, employment of two or more medications to generate anaesthesia is referred to as co-induction of anaesthesia [1,2]. As a coinduction agent, various medications have been trailed out. We'll look at the drug midazolam, its pharmacology, and how successful it is as a coinduction agent in this article. Midazolam has been proven to minimize the amount of propofol required to produce anaesthesia by up to 50% without compromising the recovery profile when administered in this fashion [3,4]. We looked at the literature on the drug midazolam and coinduction agents that was available on different platforms such as PubMed, medline, Scopus, Web of Science, and Google Scholar. We looked at several articles about midazolam and coinduction agents, as well as articles where midazolam was utilized as a coinduction agent. Prior observational studies and case reports using midazolam as a coinduction agent were mentioned in this article. After studying about midazolam's pharmacology, usage, indications, contraindications, as well as past observational studies and case reports, The substance can be used as a coinduction agent and has a variety of purposes in anaesthesia.

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Section: Introductionmentioning

confidence: 99%