Haemodynamic and Exocrine Effects of Caerulein at Submaximal and Supramaximal Levels on the Rat Pancreas: Role of Cholecystokinin Receptor Subtypes

Griesbacher, Thomas; Rainer, Irmgard; Heinemann, Ákos; Groisman, D.

doi:10.1159/000090025

Cited by 6 publications

(5 citation statements)

References 40 publications

(30 reference statements)

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“…However, the presence of CCK2R, identified by receptor autoradiography in the acini of chronic pancreatitis, indicates that human acini have the potential to express CCK2R (409). On the other hand, recent data suggesting that CCK2R is involved in the regulation of pancreatic blood flow and vascular conductance might warrant further localization investigations with regard to human pancreas (185).…”

Section: Exocrine Pancreasmentioning

confidence: 99%

Cholecystokinin and Gastrin Receptors

Dufresne

Seva²,

Fourmy³

2006

Physiological Reviews

417

418

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Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled receptors that have been the subject of intensive research in the last 10 years with corresponding advances in the understanding of their functioning and physiology. In this review, we first describe general properties of the receptors, such as the different signaling pathways used to exert short- and long-term effects and the structural data that explain their binding properties, activation, and regulation. We then focus on peripheral cholecystokinin receptors by describing their tissue distribution and physiological actions. Finally, pathophysiological peripheral actions of cholecystokinin receptors and their relevance in clinical disorders are reviewed.

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Section: Exocrine Pancreasmentioning

confidence: 99%

Cholecystokinin and Gastrin Receptors

Dufresne

Seva²,

Fourmy³

2006

Physiological Reviews

417

418

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“…Indeed, in Sprague–Dawley rats, CCK mediated vasodilatation of the mesenteric vascular bed via its pre-synaptic CCKR-2 release [37]. Similarly caerulein, a CCK analogue, was shown to increase pancreatic blood flow and vascular conductance in rat via activation of CCKR-2 receptors [38]. …”

Section: Discussionmentioning

confidence: 99%

Is there adaptation of the exocrine pancreas in wild animal? The case of the Roe Deer

et al. 2012

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BackgroundPhysiology of the exocrine pancreas has been well studied in domestic and in laboratory animals as well as in humans. However, it remains quite unknown in wildlife mammals. Roe deer and cattle (including calf) belong to different families but have a common ancestor. This work aimed to evaluate in the Roe deer, the adaptation to diet of the exocrine pancreatic functions and regulations related to animal evolution and domestication.ResultsForty bovine were distributed into 2 groups of animals either fed exclusively with a milk formula (monogastric) or fed a dry feed which allowed for rumen function to develop, they were slaughtered at 150 days of age. The 35 Roe deer were wild animals living in the temperate broadleaf and mixed forests, shot during the hunting season and classified in two groups adult and young. Immediately after death, the pancreas was removed for tissue sample collection and then analyzed. When expressed in relation to body weight, pancreas, pancreatic protein weights and enzyme activities measured were higher in Roe deer than in calf. The 1st original feature is that in Roe deer, the very high content in pancreatic enzymes seems to be related to specific digestive products observed (proline-rich proteins largely secreted in saliva) which bind tannins, reducing their deleterious effects on protein digestion. The high chymotrypsin and elastase II quantities could allow recycling of proline-rich proteins. In contrast, domestication and rearing cattle resulted in simplified diet with well digestible components. The 2nd feature is that in wild animal, both receptor subtypes of the CCK/gastrin family peptides were present in the pancreas as in calf, although CCK-2 receptor subtype was previously identified in higher mammals.ConclusionsBovine species could have lost some digestive capabilities (no ingestion of great amounts of tannin-rich plants, capabilities to secrete high amounts of proline-rich proteins) compared with Roe deer species. CCK and gastrin could play an important role in the regulation of pancreatic secretion in Roe deer as in calf. This work, to the best of our knowledge is the first study which compared the Roe deer adaptation to diet with a domesticated animal largely studied.

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“…A consistent finding under anaesthesia was the presence of a vagally evoked reflex hyperaemia in the stomach, pancreas and gut (Griesbacher et al, 2006;Heinemann et al, 1996;Mobley et al, 2006;Sartor and Verberne, 2002) although depending on the anaesthetic used, accompanying pressor or depressor effects were seen (Sartor and Verberne, 2002, 2006Mobley et al, 2007;Wisniewska and Wiśniewski, 1996).…”

Section: Biasing Effects Of Anaesthesiamentioning

confidence: 95%

CCK as a modulator of cardiovascular function

Lovick

2009

Journal of Chemical Neuroanatomy

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Haemodynamic and Exocrine Effects of Caerulein at Submaximal and Supramaximal Levels on the Rat Pancreas: Role of Cholecystokinin Receptor Subtypes

Cited by 6 publications

References 40 publications

Cholecystokinin and Gastrin Receptors

Cholecystokinin and Gastrin Receptors

Is there adaptation of the exocrine pancreas in wild animal? The case of the Roe Deer

CCK as a modulator of cardiovascular function

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