HAEMODIALYSIS MEMBRANES, SERUM Β2-Microglobulin, AND DIALYSIS AMYLOIDOSIS

Hauglustaine, D; Waer, Mark; Michielsen, Paul; Goebels, Jozef; Vandeputte, Michel

doi:10.1016/s0140-6736(86)91189-x

Cited by 99 publications

(52 citation statements)

References 8 publications

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“…The presence of p2-microglobulin in these deposits was demonstrated in all cases, a finding which is in agreement with the results of other authors [1,4].…”

supporting

confidence: 93%

“…5, 18]. This protein accumulates in the blood of patients undergoing hemodi alysis, because this procedure cannot remove a big enough quantity from the blood plasma [1,4,19]. Re cent studies indicate that (T-microglobulin serum levels increase during dialysis with cuprophane membranes and that they decrease during dialysis with polyacryloni trile (PAN) membranes [1,12].…”

Section: Discussionmentioning

confidence: 99%

“…This protein accumulates in the blood of patients undergoing hemodi alysis, because this procedure cannot remove a big enough quantity from the blood plasma [1,4,19]. Re cent studies indicate that (T-microglobulin serum levels increase during dialysis with cuprophane membranes and that they decrease during dialysis with polyacryloni trile (PAN) membranes [1,12]. This difference could be explained both by the better removal of (T-microglobulin by PAN due to its larger pores and also by the weaker immunological stimulation of p2-microglobulin release due to the better biocompatibility of PAN [1,12].…”

Section: Discussionmentioning

confidence: 99%

“…These findings suggest that, in contrast to what had been thought previously, dialysis amyloidosis could have systemic as well as visceral distribution. The amyloid deposits found were resistant against potassium permanganate treatment and reacted with anti-human (32-microglobulin antibody.Recently, it has been demonstrated that amyloidosis affecting bones, joints and synovia is an important com plication of long-term hemodialysis [1,2]. The amyloid arthropathy of hemodialysis patients is characterized by carpal tunnel syndrome, persistent oligoarticular swell ing and effusions mainly in the knees and shoulders, lytic bone lesions and erosive spondiloarthropathy [2,3].…”

mentioning

confidence: 99%

“…The amyloid arthropathy of hemodialysis patients is characterized by carpal tunnel syndrome, persistent oligoarticular swell ing and effusions mainly in the knees and shoulders, lytic bone lesions and erosive spondiloarthropathy [2,3]. He modialysis-associated amyloidosis appears to have a lo cal rather than a systemic involvement, although its full extent is yet to be determined [4][5][6], Recent reports indi cate that P2-microglobulin is the major constituent pro tein in this new form of amyloidosis [1,4).…”

mentioning

confidence: 99%

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Visceral Involvement of Dialysis Amyloidosis

Campistol¹,

Cases²,

Torrás³

et al. 1987

Am J Nephrol

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Carpal tunnel syndrome, peripheral arthropathy, erosive spondiloarthropathy and lytic bone lesions have all been associated with dialysis amyloidosis. Recent studies indicate that β₂-microglobulin is the major constituent protein in this new form of amyloidosis. Dialysis amyloidosis was reported to have a local rather than a systemic involvement, although its full extent is yet to be determined. We investigated 3 patients on maintenance hemodialysis with bilateral caφal tunnel syndrome and amyloid arthropathy and found amyloid depositions in several organs. These findings suggest that, in contrast to what had been thought previously, dialysis amyloidosis could have systemic as well as visceral distribution. The amyloid deposits found were resistant against potassium permanganate treatment and reacted with anti-human β₂-microglobulin antibody.

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“…The presence of p2-microglobulin in these deposits was demonstrated in all cases, a finding which is in agreement with the results of other authors [1,4].…”

supporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Visceral Involvement of Dialysis Amyloidosis

Campistol¹,

Cases²,

Torrás³

et al. 1987

Am J Nephrol

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Musculoskeletal manifestations in β₂‐microglobulin amyloidosis. Case discussion

Gravallese

Baker

Lester

et al. 1992

Arthritis & Rheumatism

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Case 1. Patient 1 is a 60-year-old woman with polycystic kidney disease. By 1974 she had developed end-stage renal disease complicated by hypertension. Hemodialysis was required, and dialysis against a cuprophane membrane was carried out for 15 years through an arteriovenous fistula in the left arm.In 1981, mild diffuse bone pain developed. She also noted tingling and numbness in the left hand and fingers, which was worse in the morning. A diagnosis of carpal tunnel syndrome was made, and she was treated with splinting and nonsteroidal antiinflammatory agents. In 1985 at an outside hospital, she underwent surgical decompression of the median nerve in the left carpal tunnel. In 1986, she underwent a bone biopsy of the right iliac crest, and deferoxamine mesylate was prescribed for treatment of osteomalacia with aluminum deposition. Laboratory values at that time included a serum calcium of 10.4 mg/dl, a serum phosphorus of 3.2 mg/dl, and an alkaline phosphatase of 194 IUAiter (normal 16-95). Results of tests for antinuclear antibodies and rheumatoid factor were negative.From 1986 to 1987, the patient experienced chronic

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