Haemodialysis in rats

Röckel, A; Brand, Angelika; Stanjek, A.; Hevendehl, G; Heidland, A.; Hoeltzenbein, J; Pedersen, F. S.

doi:10.1007/bf01851410

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…Therefore, this is the first study to evaluate drug dialyzability using in vivo model and extrapolate the drug dialyzability from in vivo model to human. On the benefits of this model, HD rat more reflects clinical condition than previous studies [4,5,[33][34][35], such as…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, HD rat which can reflect Vd and evaluate drug removal rate is higher predictability of drug removal than in vitro drug clearance of dialyzer. Moreover, several previous studies have shown that in vivo HD models were used for evaluating the dialyzer performance or the change of physiological parameters in HD [4,5,[33][34][35][36], but the drug dialyzability using in vivo model has never been reported. Therefore, this is the first study to evaluate drug dialyzability using in vivo model and extrapolate the drug dialyzability from in vivo model to human.…”

Section: Discussionmentioning

confidence: 99%

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In vivo evaluation of drug dialyzability in a rat model of hemodialysis

et al. 2020

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It is important to calculate the drug removal by hemodialysis (HD) for drug dosing regimens in HD patients. However, there are limited and inconsistent information about the dialyzability of drugs by HD. Therefore, the aim of our study is to evaluate drug removal by utilizing a rat model of HD (HD rat) and to extrapolate this result to the drug removal rate in HD patients. HD rats received bilateral nephrectomy and HD for 2 h. The dialysis removal of 6 drugs was evaluated in HD rats. Dialysis efficiency, plasma protein binding rate (PBR) and distribution volume (Vd) of drugs were also measured. Furthermore, we examined the correlation between the dialyzability of drug in HD rats and humans and constructed the prediction formula of the drug dialyzability in HD patients. The clearance of urea and creatinine and normalized dialysis dose in HD rats were 0.83 ± 0.07 mL/min, 0.70 ± 0.08 mL/min, and 0.13 ± 0.06, respectively. The drug dialyzability in HD rats was similar to reported clinical data except for doripenem. A higher correlation was observed between drug dialyzability in reported clinical data and HD rats which were adjusted for PBR (r 2 = 0.936; p < 0.001) compared to unadjusted (r 2 = 0.812; p = 0.009). Therefore, we constructed the prediction formula of the drug dialyzability in HD patients by utilizing the HD rat model and PBR. This study is useful for evaluating the dialyzability of high-risk drugs in a clinical setting and might provide appropriate preclinical dialyzability data for new drug.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In vivo evaluation of drug dialyzability in a rat model of hemodialysis

et al. 2020

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“…The dialysis procedures were modified according to the methods described earlier [29][30][31]. The hollow-fiber dialysis membranes Cupro, Hemo, and AN69 were placed into minidialyzers (courtesy of Dr. J. Vienken, AKZO.…”

Section: Hemodialysis Sessionsmentioning

confidence: 99%

Recovery from Ischemic Acute Renal Failure: Independence from Dialysis Membrane Type

1996

Nephron

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Exposure to complement-activating cellulosic dialysis membranes has been claimed to adversely affect the course of acute renal failure. To test this hypothesis, male Sprague-Dawley rats were allocated to two groups: in group I, acute renal failure was induced by bilateral renal artery clamping, while group II animals underwent a sham procedure. In each group, the rats were further allocated to undergo hemodialysis with either a Cuprophan, a Hemophan, or a PAN miniDialyzer membrane 3 and 7 days after surgery or no dialysis. The renal function was measured by inulin clearance on the days following dialysis. Temporary occlusion of the renal arteries led to a rapid increase in serum urea and creatinine levels that peaked between 24 and 48 h after surgery and declined slowly thereafter. Peak urea values were similar in the acute renal failure groups. The hemodialysis sessions were well tolerated. Degree and rate of recovery were similar in all acute renal failure groups irrespective of whether they underwent dialysis or not or the type of the dialysis membrane. Complete recovery was observed in all the acute renal failure groups by the end of the observation period. Our findings refute the hypothesis that in ischemic acute renal failure exposure to complement-activating cellulosic dialysis membranes impairs the recovery of renal function.

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Effects of acute hemodialysis-induced changes in sodium balance on the renin-angiotensin system in renovascular and spontaneously hypertensive rats

et al. 1979

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In two-kidney Goldblatt hypertensive, spontaneously hypertensive, and normotensive control rats the activity of the renin-angiotensin system was tested during variation of sodium balance. Acute, exactly calculable and selective changes of total body sodium were achieved by hemodialyzing the conscious rats using dialysate with either high or low sodium content. The activity of the RAS was evaluated by blood pressure response to AT II blockade (saralasin bolus injection; 25 micrograms/kg b.w., i.v.) and the plasma-renin activity. During sodium depletion blood pressure maintenance became renin-dependent; sodium loading caused a decrease of renin-angiotensin activity in renovascular hypertension. A weak direct correlation between deprssor response to saralasin and the PRA could be established in the different sodium-depleted and -loaded states.

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Haemodialysis in rats

Cited by 6 publications

References 8 publications

In vivo evaluation of drug dialyzability in a rat model of hemodialysis

In vivo evaluation of drug dialyzability in a rat model of hemodialysis

Recovery from Ischemic Acute Renal Failure: Independence from Dialysis Membrane Type

Effects of acute hemodialysis-induced changes in sodium balance on the renin-angiotensin system in renovascular and spontaneously hypertensive rats

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