Haemocompatibility evaluation of DLC- and SiC-coated surfaces

Abstract

Diamond-like carbon (DLC) and silicon carbide (SiC) coatings are attractive because of low friction coefficient, high hardness, chemical inertness and smooth finish, which they provide to biomedical devices. Silicon wafers (Si waf ) and silicone rubber (Si rub ) plates were coated using plasmaenhanced chemical vapour deposition (PE-CVD) techniques. This article describes: 1-the characterization of modified surfaces using attenuated total reflection-Fourier transform infrared spectroscopy (ATR/FTIR) and contact angle measurements, 2-the results of three in-vitro haemocompatibility assays. Coated surfaces were compared to uncoated materials and various substrates such as polymethylmethacrylate (PMMA), polyethylene (LDPE), polydimethylsiloxane (PDMS) and medical steel (MS). Thrombin generation, blood platelet adhesion and complement convertase activity tests revealed the following classification, from the most to the least heamocompatible surface: Si rub / DLC-Si rub / DLC-Si waf / LDPE/ PDMS/ SiCSi waf / Si waf / PMMA/ MS. The DLC coating surfaces delayed the clotting time, tended to inhibit the platelet and complement convertase activation, whereas SiC-coated silicon wafer can be considered as thrombogenic. This study has taken into account three events of the blood activation: coagulation, platelet activation and inflammation. The response to those events is an indicator of the in vitro haemocompatibility of the different surfaces and it allows us to select biomaterials for further in vivo blood contacting investigations.

Fundamentals of Biomedical Applications of Biomorphic SiC

“…Three studies (on 2,125 patients) showed a benefit that was attributed to the SiC-coated stent (Elbaz et al, 2002;Hamm et al, 2003; Properties and Applications of Silicon Carbide 302 Kalnins et al, 2002). In a direct comparison of silicon wafers and SiC-coated (PECVD) silicon wafers for blood compatibility, both appeared to provoke clot formation to a greater extent than diamond-like coated silicon wafers; silicon was worse than SiC-coated silicon (Nurdin et al, 2003). In conclusion, the haemocompatibility of SiC was demonstrated.…”

Predicting Glucose Sensor Behavior in Blood Using Transport Modeling: Relative Impacts of Protein Biofouling and Cellular Metabolic Effects

“…The protocol for scanning electron microscope (SEM) was modified from Nurdin and coauthors 19 and is described in the Appendix.…”

Formation of SiC thin films by chemical vapor deposition with vinylsilane precursor

“…SiC is an attractive material for metal surface coatings, 1,2) photoelectrodes, 3) solar cells, 4) ultraviolet photodetectors, 5) power devices, 6,7) and other devices because it has excellent material properties such as a large energy band gap, a high chemical stability, a high robustness, a high thermal conductivity, and conductivity controllability through impurity doping. 8) These properties of SiC thin films are also preferable for the application of electrode coatings to water electrolysis technology.…”