A 66-year-old insulin-requiring diabetic male with diabetes secondary to pancreatic damage from alcohol abuse, with well-established alcoholic liver disease and cirrhosis, developed obstructive jaundice from gall stones and later from a biliary stricture associated with gram-negative septicaemia. Death occurred from a haemorrhagic cholecystitis with ruptured gall bladder. At autopsy, a surprise finding was a non-functioning pancreatic islet cell tumour invading the ampulla of Vater. Cholestasis in this case was due to multiple factors. Copyright
Autopsy findingsThe main post-mortem findings were a markedly dilated, haemorrhagic, inflamed perforated gallbladder filled with blood-stained bile and containing multiple small mixed stones with some gravel. The wall of the gall-bladder was diffusely haemorrhagic, almost gangrenous, inflamed and had perforated along the inferior surface of the fundus. The perforation was 3-4mm in maximum dimension (Figures 1 and 2). The common bile duct was markedly dilated, contained multiple small mixed stones, each a few millimetres and a 7cm long plastic stent, extending from the ampulla to the junction of the right and left hepatic bile duct. The plastic stent was in situ and with no local complications. There was no perforation or rupture of the common bile duct. The perforated acute haemorrhagic cholecystitis was accompanied by localised peritonitis but there was no macroscopic evidence of generalised peritonitis.The liver was deeply green and cirrhotic with a fine nodular cut surface (Figures 3 and 4). The head of the pancreas was mostly occupied by an ill-defined firm and scirrhous tumour, histologically proven to be an islet cell tumour (Figures 5 and 6). The tumour at the head of the pancreas has obstructed the junction of the common bile duct and main pancreatic duct as they join to form the ampulla of Vater. There was no evidence of regional lymph node, liver or lung metastases. The distal part of the main pancreatic duct contained a 1.8cm calculus accompanied by features of chronic pancreatitis. There was no evidence of acute pancreatitis.
Discussion
CLINICO-PATHOLOGICAL CONFERENCE An unusual case of jaundice in secondary diabetes
IN:Perforation of the gall-bladder can also occur due to gallstones without predisposing haemorrhagic cholecystitis.SRL: This is so but gall-bladder perforation secondary to gallstones is very uncommon. A retrospective audit carried out at UCLA affiliated hospitals identified only 51 confirmed cases over a 27-year period. 3 RMR: It would appear that this patient had five possible causes of his jaundice.IWC: That is correct and these are summarised in Table 2. It is important in any patient, diabetic or non-diabetic, to always consider more than one cause as these different aetiologies may co-exist.
IN:In my pathological experience it is very unusual to have so many causes, some rare, in one patient.SRL: Why does septicaemia cause jaundice?IWC: Patients with sepsis often develop cholestasis due to the activation of inflammatory cyto...