Haematolytic disease due to ABO incompatibility: Incidence and value of screening in an Asian population

Han, Ping; Ramesh, Karthik; Ong, R.; Joseph, R; Tan, K. L.; Wong, Hee-Kit

doi:10.1111/j.1440-1754.1988.tb01329.x

Cited by 14 publications

(12 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In an earlier published study the sensitivity and specificity were lower at 53 and 73%, respectively. 8 The low positive predictive value of the newborn DAT for clinically significant ABO HDN has been confirmed previously 9,10 and a number of studies have concluded that routine testing is not necessary. 7,[11][12][13][14] Conversely, evidence exists to support that a positive DAT is associated with an increased incidence of jaundice and more severe ABO HDN.…”

Section: Discussionmentioning

confidence: 84%

See 1 more Smart Citation

Review of positive direct antiglobulin tests found on cord blood sampling

Dinesh¹

2005

J Paediatrics Child Health

View full text Add to dashboard Cite

The positive predictive value of a positive DAT for HDN is 23%. The sensitivity was estimated to be 86%. Ten babies required readmission for phototherapy, two of these were DAT-positive. Jaundice, rather than the positive DAT, was the first alert in the majority of cases of HDN requiring phototherapy. Recommendations for testing are discussed but remain controversial in practice. Assessment for hyperbilirubinaemia in all infants early in life is fundamental.

show abstract

Section: Discussionmentioning

confidence: 84%

“…The low positive predictive value of the newborn DAT for clinically significant ABO HDN has been confirmed previously 9,10 and a number of studies have concluded that routine testing is not necessary 7,11–14 …”

Section: Discussionmentioning

confidence: 84%

Review of positive direct antiglobulin tests found on cord blood sampling

Dinesh¹

2005

J Paediatrics Child Health

View full text Add to dashboard Cite

show abstract

“…3 Various screening tests for predicting severity have been studied. 2,4,6,11,12 However, some studies have found that routine screening tests for predicting ABO haemolytic disease are not helpful 13,14 and thus are not cost-effective.…”

Section: Discussionmentioning

confidence: 98%

Morbidity of ABO haemolytic disease in the newborn

Bhat

Chettiar

2012

Paediatrics and International Child Health

View full text Add to dashboard Cite

show abstract

“…Kiruba RHP et al in his study found out that it was 3.7%. 7 Present study showed that the cord bilirubin >1.8mg/dl and hemoglobin <15.1gm/dl were more prone for pathological hyperbilirubinemia. This was similar to the previous study by Rataj et al in which cord bilirubin of >2.5 were prone for pathological jaundice.…”

Section: Discussionmentioning

confidence: 46%

Evaluation of cord bilirubin and hemoglobin analysis in predicting pathological jaundice in term babies at risk of ABO incompatibility

2016

View full text Add to dashboard Cite

INTRODUCTIONNeonatal jaundice is the most common condition for which a newborn is admitted and evaluated in NICU. 1 85% of the term and most of the preterm neonates develop hyperbilirubinemia. Also 6.1% of well term newborn have a maximal serum bilirubin level >12.9mg/dl. A serum bilirubin greater than 15mg/dl is seen in 3% of normal full term neonates. 2When early discharges are becoming the rule, readmission are commonly referred after 3 days for the management of jaundice with phototherapy.3 So it becomes all the more important that pathological hyperbilirubinemia is picked up early and treatment started to prevent kernicterus. Biochemical evaluation of total and conjugated bilirubin based on Vanden Bergh reaction is still the gold standard for bilirubin estimation.ABO incompatibility occurs in about 20-25% of pregnancies but severe hemolytic disease develops in only one in ten of such offspring. The exact level of serum bilirubin that can cause brain damage in term and otherwise healthy infant is not predictable. Screening the babies for cord blood bilirubin and hemoglobin is important not only to protect them from kernicterus but ABSTRACT Background: Cord bilirubin and hemoglobin analysis helps not only in predicting the pathological jaundice in ABO incompatibility but also useful for early referral and intervention for better outcome. Aim of this study is to evaluate the cord blood bilirubin and hemoglobin analysis in predicting pathological hyperbilirubinemia in newborn at risk of ABO incompatibility. Methods:In this descriptive study conducted in Government Stanley medical college between January 2016-June 2016, A positive or B positive babies born to O positive mothers with birth weight >2.5 kgs and gestational age >37 weeks were included. A total of 191 babies were studied. Cord bilirubin, reticulocyte count, hemoglobin and fourth day bilirubin were evaluated and data was analysed using Pearson's Chi square and ANOVA. Results: Out of 191 babies, 25 (13%) did not develop any jaundice, 122 (64%) developed physiological jaundice and 44 (23%) had pathological jaundice. The mean cord bilirubin and cord hemoglobin values of newborn who did not develop jaundice were 1.35mg/dl and 15.3g/dl while the values among pathological jaundice were 3.15mg/dl and 14.97g/dl. Conclusions: Babies with cord bilirubin >1.8mg/dl and hemoglobin <15.1gm/dl are more prone for pathological hyperbilirubinemia.

show abstract

Haematolytic disease due to ABO incompatibility: Incidence and value of screening in an Asian population

Cited by 14 publications

References 8 publications

Review of positive direct antiglobulin tests found on cord blood sampling

Review of positive direct antiglobulin tests found on cord blood sampling

Morbidity of ABO haemolytic disease in the newborn

Evaluation of cord bilirubin and hemoglobin analysis in predicting pathological jaundice in term babies at risk of ABO incompatibility

Contact Info

Product

Resources

About