Haematological values and changes in blood chemistry in chickens with infectious bursal disease

Panigrahy, B.; Rowe, Leslie; Corrier, D. E.

doi:10.1016/s0034-5288(18)30490-9

Cited by 13 publications

(5 citation statements)

References 6 publications

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“…The histopathological examination further reveals degenerated both red and white pulp of the spleen which contributes to the immunosuppressive effects of Infectious bursal disease virus in birds. These changes in the Spleen are in accordance with those reported by Rautenschlein et al (2016) [9] in infectious bursal disease in broiler chickens. Grossly, thymic atrophy is a hallmark of IBD and reflects the destruction of lymphocytes, particularly in the thymic cortex.…”

Section: Discussionsupporting

confidence: 93%

“…The clinical signs like depression, reluctant to move, watery diarrhea, dehydration, ruffled feather, trembling, gasping and vent picking were recorded in IBD affected birds. The Hb, PCV, TEC and TLC in the affected broiler chickens were low as compared to normal broiler chickens in this study, which is accompanied with work of Panigrahy et al (1996) [9] and Mahmood et al (2018) [7] . The increase in AST, ALT and Creatinine activity might be attributed due to hepatopathy and nephropathy observed in the infected birds which were previously reported by Muller et al (2012) [8] and Cortes et al (2005) [3] .…”

Section: Discussionsupporting

confidence: 84%

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In vivo pathological evaluation of naturally occurring infectious Bursal disease in broiler chicken reared under temperate climatic conditions of Kashmir

Shafi,

Shabir,

Rather

et al. 2024

Int. J. Adv. Biochem. Res.

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A case compilation study was conducted to assess the clinical signs, hematological and pathomorphological changes observed in the Infectious bursal disease in broiler chicken reared in Ganderbal district of Kashmir valley during the period of May to August, 2019 in commercial broiler farms at Ganderbal district of Kashmir. During this study, a total of 50 sick birds showing characteristics clinical signs of Infectious Bursal Disease and 15 death birds that were brought to the Division of Veterinary pathology for detailed postmortem examination. The confirmation of cases was performed by detection of gross and histopathology of the organs. The blood samples from 20 randomly selected sick birds were tested to routine hematology. The birds showed lymphocytes were highest and basophils were lowest percentages in IBD suspected broiler chicken. The disease was found to occur all around the year and highest incidence was observed during winter. The clinical signs included dullness, depression, anorexia, ruffled feathers and yellow diarrhea. On necropsy, birds showed darkened discolouration of thigh and breast muscles with paint brush like hemorrhages and enlarged bursa with accumulation of thick mucoid, creamy or bloody exudates. Some birds showed congestion and hemorrhages at the junction of bursa and proventriculus. Microscopically, lymphoid depletion, formation of cysts filled with necrotic debris, heterophils and diffused hemorrhages were observed in bursa. This disease remains an economical threat to the poultry industry and require regular monitoring in order to prevent occurrence of disease in poultry farms

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 84%

In vivo pathological evaluation of naturally occurring infectious Bursal disease in broiler chicken reared under temperate climatic conditions of Kashmir

Shafi,

Shabir,

Rather

et al. 2024

Int. J. Adv. Biochem. Res.

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“…Previous studies demonstrated the connection between IBD infection and a decrease of blood erythrocytes concentrations when our data suggested otherwise [ 54 ]. Since the purity of the IBDV viral stocks used in this article might not have been assessed like in ours and given that their method for measuring the blood cells concentrations differs from ours, we can hypothesize that the divergence of conclusions among the two studies may be caused by those two elements.…”

Section: Discussionsupporting

confidence: 60%

Infectious bursal disease virus: predicting viral pathotype using machine learning models focused on early changes in total blood cell counts

Molinet,

Courtillon,

Bougeard

et al. 2023

Vet Res

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Infectious bursal disease (IBD) is an avian viral disease caused in chickens by infectious bursal disease virus (IBDV). IBDV strains (Avibirnavirus genus, Birnaviridae family) exhibit different pathotypes, for which no molecular marker is available yet. The different pathotypes, ranging from sub-clinical to inducing immunosuppression and high mortality, are currently determined through a 10-day-long animal experiment designed to compare mortality and clinical score of the uncharacterized strain with references strains. Limits of this protocol lie within standardization and the extensive use of animal experimentation. The aim of this study was to establish a predictive model of viral pathotype based on a minimum number of early parameters measured during infection, allowing faster pathotyping of IBDV strains with improved ethics. We thus measured, at 2 and 4 days post-infection (dpi), the blood concentrations of various immune and coagulation related cells, the uricemia and the infectious viral load in the bursa of Fabricius of chicken infected under standardized conditions with a panel of viruses encompassing the different pathotypes of IBDV. Machine learning algorithms allowed establishing a predictive model of the pathotype based on early changes of the blood cell formula, whose accuracy reached 84.1%. Its accuracy to predict the attenuated and strictly immunosuppressive pathotypes was above 90%. The key parameters for this model were the blood concentrations of B cells, T cells, monocytes, granulocytes, thrombocytes and erythrocytes of infected chickens at 4 dpi. This predictive model could be a second option to traditional IBDV pathotyping that is faster, and more ethical.

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“…This reduction in haematological parameter may be due to diseases which were confirmed in the histological indices of the broilers chicken and may not have link to the feed. Available information indicates that haematological values of avian species are significantly influenced by poultry diseases including fowl typhoid [21], mycoplasmosis [22], avian coccidiosis [23], infectious bursal disease [24,25], Newcastle disease [26] and toxoplasmosis [27]. Mohammad and Oloyede [28] reported significant reductions in the haematological contents of the blood of broiler chicks fed A. niger-fermented T. catappa seed meal-based diet [28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Rhizopus Oryzae May Reduce Toxic Effects of Raw Mango Seed Kernel Amendment in the Diet of Broilers

Ibrahim¹

2018

NFSIJ

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Studies on the histological and haematological indices of broilers fed Rhizopus oryzae fermented mango (Mangnifera indica) seed kernel was conducted. Mango seed kernels were seeded with Rhizopus oryzae and allowed to ferment for ten days. Bird fed fermented mango seed kernels had a mean weight of 2.35kg before slaughtering and 2.2kg after slaughtering. The mean weight of the organs were 13.3g for lungs, 8.5g for heart, 4.1g for the intestine, 1.3g for spleen, 47.9g for liver, 5.4g for bursa and 11.2g for kidney. Histological observation revealed hemorrhages and necrosis in the lung and intestine of the birds and the bursa was inflammed. The mean haematological value was 25.5% for PCV, 2.10x10 6 M/µl for RBC and 21.65x10 3 M/µl for WBC. The full blood count revealed that the chicken had neutrophils value of 9%, lymphocytes 86%, monocytes 5% and eosinophils 1.0%. In conclusion, Rhizopus oryzae could be exploited to reduce the toxic effects of raw mango seed kernels and 50% of maize could be replaced with fermented mango seed kernel in the diet of broilers without adverse effect on growth, histological and hematological indices.

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Haematological values and changes in blood chemistry in chickens with infectious bursal disease

Cited by 13 publications

References 6 publications

In vivo pathological evaluation of naturally occurring infectious Bursal disease in broiler chicken reared under temperate climatic conditions of Kashmir

In vivo pathological evaluation of naturally occurring infectious Bursal disease in broiler chicken reared under temperate climatic conditions of Kashmir

Infectious bursal disease virus: predicting viral pathotype using machine learning models focused on early changes in total blood cell counts

Rhizopus Oryzae May Reduce Toxic Effects of Raw Mango Seed Kernel Amendment in the Diet of Broilers

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