Haematological profile of healthy elderly Australians

Silagy, Christopher; Salem, Haitham; Campion, Katrina; McNeil, John J; Robert, J; Donnan, Geoffrey A; Tonkin, A.; Worsam, Bernard

doi:10.5694/j.1326-5377.1992.tb137036.x

Cited by 8 publications

(3 citation statements)

References 14 publications

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“…Figures A–B (see also Tables S1.1–S7.1, online only; for Refs. , see these tables) show the lower limits of Hb reference values reported in the 60 papers that qualified for this portion of the review, based on the criteria described above. The WHO reference value for children 2–6 months (Fig.…”

Section: Variation In Average Hb Values Across Life Stages and By Sexmentioning

confidence: 99%

Variation in hemoglobin across the life cycle and between males and females

Jorgensen

Crespo-Bellido

Dewey

2019

Annals of the New York Academy of Sciences

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WHO recommendations for hemoglobin (Hb) cutoffs to define anemia are based on a handful of studies conducted in the 1960s that did not include participants from all life stages. To evaluate whether there is a need to update Hb cutoffs, we conducted a narrative review of the literature to identify more recent studies that have reported Hb cutoffs in males and females in various life stages. We compiled information from 60 studies conducted around the globe between 1975 and 2018. Many studies reported cutoffs that were similar to WHO recommendations, but cutoffs identified in studies of infants, young children, premenopausal women, and the elderly tended to be lower than WHO recommendations, while cutoffs identified in studies of men tended to be higher than WHO cutoffs. Few studies excluded individuals with iron deficiency or inflammation, which limits the conclusions that can be drawn regarding normal reference ranges. Further research using more stringent exclusion criteria is needed to develop revised recommendations for Hb cutoffs to define anemia.

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Section: Variation In Average Hb Values Across Life Stages and By Sexmentioning

confidence: 99%

Variation in hemoglobin across the life cycle and between males and females

Jorgensen

Crespo-Bellido

Dewey

2019

Annals of the New York Academy of Sciences

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“…Sex [ 9 , 10 ], ethnicity [ 11 , 12 ], environmental conditions [ 5 , 13 ], and seasonal differences are known to influence platelet counts [ 4 ]. Hence, the concept of adjusted platelet counts has been proposed in order to reduce misdiagnoses of thrombocytopenia.…”

Section: Introductionmentioning

confidence: 99%

Mean platelet volume is more important than age for defining reference intervals of platelet counts

et al. 2019

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BackgroundPlatelet count is known to be associated with sex, age and mean platelet volume (MPV). Sex and age were proposed for adjustment of platelet count reference intervals, but MPV is currently not used for further adjustment. We investigated the association of MPV, age and sex with platelet counts and established individualized reference ranges respecting MPV.MethodsThe association of platelet count with age, sex and MPV was assessed in healthy participants (n = 3,033 individuals; 1,542 women) in the cross-sectional population-based cohort Study of Health in Pomerania. Reference intervals respecting age, sex, and MPV were estimated using quantile regressions for the 2.5th and 97.5th percentile.ResultsWomen had higher platelet counts than men (239 vs. 207 x109/L, p<0.001). Platelet counts correlated with age (p<0.001) and MPV (p<0.001). Quantile regression of lower and upper platelet count limits correlated less with age in female (p = 0.047 for 2.5th percentile; p = 0.906 for 97.5th percentile) and male subjects (p = 0.029 for 2.5th percentile; p = 0.195 for 97.5th percentile) compared to MPV (p<0.001 for upper and lower limit for both sexes). After adjustment for MPV, age did no longer correlate with the 2.5th (p = 0.165) or 97.5th percentile (p = 0.999) of platelet count. In contrast, after adjustment for age, MPV levels still significantly correlated with 2.5th, 50th and 97.5th percentile (p<0.001).ConclusionMPV and sex have a stronger association with platelet count than age. MPV should be considered to adjust platelet count reference intervals and needs to be respected as confounder for platelet counts in epidemiological studies and clinical practice.

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“…The platelet count, a component of the full blood count, has been identified as a useful diagnostic marker for cancer in patients presenting to primary care. The standard reference range for the platelet count in the UK is 150 to 400 or 450 × 109/l (1) irrespective of the age or sex of the patient; we know that platelet count varies by age and sex in healthy populations (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Improving the Clinical Utility of Platelet Count in Primary Care with Age- and Sex-Stratified Upper Thresholds Suggestive of an Undiagnosed Cancer: A Cohort Study Set in Primary Care in England, Canada, and Australia

Mounce,

Calitri,

Hamilton

et al. 2024

Preprint

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The platelet count, a component of the full blood count, has been identified as a useful diagnostic marker for cancer in primary care. The reference range for the platelet count is 150 to 400 or 450 × 109/l; this range does not account for natural variation in platelet count by age and sex. This study used three primary care cohorts from England Canada, and Australia. Patients aged 40 years and over with a full blood count were included and stratified by age (in 10-year bands), sex, (male/female), and platelet count group. Cancer incidence within one year of test date was estimated from linked registry data. In all three countries there was a clear upwards trend in cancer incidence with increasing platelet count, for both sexes and at all age groups. Lung and colorectal were the most common sites. These results have important implications for the international application of this work; analysis of local health datasets will be crucial to determine appropriate thresholds. Appropriate upper thresholds will depend on local populations, healthcare needs, and priorities. Further research is needed to assess the likely impact of new recommendations on the healthcare system, on cancer outcomes, and patient benefit.

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Haematological profile of healthy elderly Australians

Cited by 8 publications

References 14 publications

Variation in hemoglobin across the life cycle and between males and females

Variation in hemoglobin across the life cycle and between males and females

Mean platelet volume is more important than age for defining reference intervals of platelet counts

Improving the Clinical Utility of Platelet Count in Primary Care with Age- and Sex-Stratified Upper Thresholds Suggestive of an Undiagnosed Cancer: A Cohort Study Set in Primary Care in England, Canada, and Australia

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