Haematological Profile in Cancer Patients: Analysis of Circadian Pattern

Manfredini, Roberto; Salmi, Raffaella; Gallerani, Massimo; Portaluppi, Francesco; Guerra, Giselle; Scapoli, Chiara; Dapporto, M; Degani, D; Maestri, A; Franceschini, F

doi:10.1177/030006059402200606

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…However, the results of the experiment in which blood was sampled repeatedly during the day, failed to show any significant fluctuations in Hb and Ht. The diurnal changes as found by Wisser and Breuer [14] and Manfredini et al [8] may be attributable to changes in fluid intake and different hydration status during the day. Especially during sleep when subjects may have an increased diuresis and no fluid intake, hemoconcentration is likely to occur.…”

Section: Discussionmentioning

confidence: 84%

“…The data show that the Hb and Ht levels remained fairly stable from one hour after infusion throughout the whole 8-hour observation period. One might argue that the decrease in Hb and Ht is not only attributable to the saline infusion, but also to daily fluctuations since Wisser and Breuer [14] and Manfredini et al [8] have shown that Hb and Ht show a diurnal rhythm, with a decline during the day. However, the results of the experiment in which blood was sampled repeatedly during the day, failed to show any significant fluctuations in Hb and Ht.…”

Section: Discussionmentioning

confidence: 99%

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Hemoglobin and Hematocrit Values After Saline Infusion and Tourniquet

Kuipers¹,

Brouwer²,

Dubravčić-Šimunjak³

et al. 2005

Int J Sports Med

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This study attempted to contribute to standardization of blood testing in sport, and to investigate the effect of artificial dilution with saline. In 10 healthy, physically active males and 3 healthy physically active females hemoglobin (Hb), hematocrit (Ht), and % reticulocytes (%retics) were measured at different time points to look for possible fluctuations during day time, while the subjects had regular coffee breaks and lunch. In 7 of the subjects in a separate experiment 500 ml of saline were infused around 8 am and Hb, Ht, and %retics were measured before and every hour thereafter until 7 hours after infusion. In addition Ht was measured on a hematological analyzer as well as with a centrifuge. In a separate experiment the effect of tourniquet duration on Hb and Ht was studied in 9 of the subjects. The results show that Hb, Ht, and %retics are stable from 8 am to 4 pm, but that infusion of 500 ml of saline induces an acute decrease in Hb and Ht within one hour (Hb decreased from 15.2+/-0.9 g/dl to 14.5+/-1.0 g/dl, and Ht from 45.6+/-2.8 % to 44.0+/-2.5 %). The decline in Hb and Ht was maintained during the 7-hour observation period. Ht values of the same samples measured with a hematological analyzer and a centrifuge were not different. Application of the tourniquet did significantly affect Hb and Ht values only from two minutes, and thereafter Hb and Ht remained stable during the rest of the 5-minute tourniquet. With blood testing in sport these results have to be taken into consideration.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Hemoglobin and Hematocrit Values After Saline Infusion and Tourniquet

Kuipers¹,

Brouwer²,

Dubravčić-Šimunjak³

et al. 2005

Int J Sports Med

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Seasonal Variation in Onset of Myocardial Infarction—A 7‐year single‐center study in Italy

Manfredini

Boari

Smolensky

et al. 2005

Chronobiology International

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Like many other serious acute cardiovascular and cerebrovascular events, acute myocardial infarction (AMI) shows seasonal variation, being most frequent in the winter. We sought to investigate whether age, gender, and hypertension influence this pattern. We studied 4014 (2259 male and 1755 female) consecutive patients with AMI presenting to St. Anna Hospital of Ferrara, Italy between January 1998 and December 2004. Some 1131 (28.2%) of the AMI occurred in persons <65 yrs of age, and 2883 (71.8%) in those > or =65 yrs of age. AMI was over-represented in males (82% in the <65 yr group vs. 56.6% in the > or =65 yr group (chi2=13.99; p<0.001). Hypertension had been previously documented in 964 (24%) of the cases. There were 691 (17.2%) fatal case outcomes; fatal outcomes were significantly higher among the 3054 normotensive (n=614 or 20.1%) than the 964 hypertensive cases (n=77 or 8%; chi2=74.94, p<0.001). AMIs were most frequent in the winter (n=1076 or 26.8% of all the events) and least in the summer (n=924 or 23.0% of all the events; chi2=12.36, p=0.007). The greatest number of AMIs occurred in December (n=379 or 9.44%), and the lowest number in September (n=293 or 7.3%; chi2=11.1, p=0.001). Inferential chronobiological (Cosinor) analysis identified a significant annual pattern in AMI in those > or =65 yrs of age, with a peak between December and February-January for the total sample (p<0.005), January for the sample of males (p=0.014), February for fatal infarctions (p=0.017), and December for non-fatal infarctions (p=0.006). No such temporal variations were detected in any of these categories in those <65 yrs of age. The annual pattern in AMI was also verified by Cosinor analysis in the following hypertensive subgroups: hypertensive males (n=552: January, p=0.014), non-fatal infarctions in hypertensive patients (n=887: January, p=0.018), and elderly normotensives (n=1556: November, p=0.007).

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Seasonal Variation in Occurrence of Pulmonary Embolism: Analysis of the Database of the Emilia‐Romagna Region, Italy

Gallerani

Boari

Smolensky

et al. 2007

Chronobiology International

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Seasonal variation in the occurrence of cardiovascular and cerebrovascular events, including pulmonary embolism (PE), has been reported; however, recent large-scale, population-based studies conducted in the United States did not confirm such seasonality. The aim of this large-scale population study was to determine whether a temporal pattern in the occurrence of PE exists. The analysis considered all consecutive cases of PE in the database of all hospital admissions of the Emilia Romagna region in Italy at the Center for Health Statistics between January 1998 and December 2005. PE cases were first grouped according to season of occurrence, and the data were analyzed by the chi(2) test for goodness of fit. Then, inferential chronobiologic (cosinor and partial Fourier) analysis was applied to monthly data, and the best-fitting curve for the annual variation was derived. The total sample consisted of 19,245 patients (8,143 male, mean age 71.6+/-14.1 yrs; 11,102 female, mean age 76.1+/-13.7 yrs). Of these, 2,484 were <65 yrs, 5,443 were between 65 and 74, and 11,318 were > or = 75 yrs. There were 4,486 (23.3%) fatal-case outcomes. PE occurred least frequently in spring (n=4,442 or 23.1%) and most frequent in winter (n=5,236 or 27.2%, goodness of fit chi(2)=75.75, p<0.001). Similar results were obtained for subgroups formed by gender, age, fatal/non-fatal outcome, presence/absence of major underlying co-morbid conditions, and specific risk factors. Inferential chronobiological analysis identified a significant annual pattern in PE, with the peak between November and December for the total sample of cases (p<0.001), males (p<0.001), females (p=0.002), fatal and non-fatal cases (p<0.001 for both), and subgroups formed by age (<65 yrs, p=0.012; 65-74 yrs, p<0.001; > or = 75 yrs, p=0.012). This pattern was independent of the presence/absence of hypertension (p=0.003 and p<0.001, respectively), pulmonary disease (p<0.001 and p<0.001, respectively), stroke (p<0.001 and p=0.004, respectively), neoplasms (p=0.005 and p=0.001, respectively), heart failure (p=0.022 and p<0.001, respectively), and deep vein thrombosis (p=0.002 and p<0.001, respectively). However, only a non-statistically significant trend was found for subgroups formed by cases of diabetes mellitus, infections, renal failure, and trauma.

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Haematological Profile in Cancer Patients: Analysis of Circadian Pattern

Cited by 6 publications

References 8 publications

Hemoglobin and Hematocrit Values After Saline Infusion and Tourniquet

Hemoglobin and Hematocrit Values After Saline Infusion and Tourniquet

Seasonal Variation in Onset of Myocardial Infarction—A 7‐year single‐center study in Italy

Seasonal Variation in Occurrence of Pulmonary Embolism: Analysis of the Database of the Emilia‐Romagna Region, Italy

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