Haematological, neurological and psychiatric complications of chronic hypothermia following surgery for craniopharyngioma

Griffiths, Ann; Henderson, M J; Penn, N. D.; Tindall, H

doi:10.1136/pgmj.64.754.617

Cited by 27 publications

(17 citation statements)

References 7 publications

(1 reference statement)

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“…8 Generally speaking, there are two ways of inducing brain hypothermia: by systemic (whole-body) cooling and local (selective) cooling. Owing to the confirmed severe adverse complications, such as shock on rewarming, increased cardiac ischaemia perioperatively and a tendency to bleed even with a normal haemostatic test in patients receiving MSH, 9 SBC has been investigated and applied in clinical studies to maximize neuroprotection while minimizing systemic complications.…”

Section: Discussionmentioning

confidence: 99%

Effects of Selective Brain Cooling in Patients with Severe Traumatic Brain Injury: A Preliminary Study

Liu

Qiu

Zhang³

et al. 2006

J Int Med Res

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We prospectively investigated noninvasive selective brain cooling (SBC) in patients with severe traumatic brain injury.Sixty-six in-patients were randomized into three groups. In one group, brain temperature was maintained at 33 -35°C by cooling the head and neck (SBC); in a second group, mild systemic hypothermia (MSH; rectal temperature 33 -35°C) was produced with a cooling blanket; and a control group was not exposed to hypothermia. Natural rewarming began after 3 days. Mean intracranial pressure 24, 48 or 72 h after injury was significantly lower in the SBC group than in the control group. Mean serum superoxide dismutase levels on Days 3 and 7 after injury in the SBC and MSH groups were significantly higher than in the control group. The percentage of patients with a good neurological outcome 2 years after injury was 72.7%, 57.1% and 34.8% in the SBC, MSH and control groups, respectively. Complications were managed without severe sequelae. Non-invasive SBC was safe and effective.

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Section: Discussionmentioning

confidence: 99%

Effects of Selective Brain Cooling in Patients with Severe Traumatic Brain Injury: A Preliminary Study

Liu

Qiu

Zhang³

et al. 2006

J Int Med Res

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“…Smith et al (31) reported absence of thirst in 19% of adults with DI treated with surgery combined or not with CRT. A loss of temperature control (very low temperature) was recorded in adult CP patients after surgery for a CP (32). Somnolence is common in adult CP patients and in the majority due to sleep apnoea (33), and disorders of sleep pattern and excessive daytime sleepiness have been recorded in up to one-third of adult CP patients (34).…”

Section: Thirst Disorder Thermoregulatory Disorders Somnolence and mentioning

confidence: 99%

Endocrine aspects and sequel in patients with craniopharyngioma

Erfurth

2015

Journal of Pediatric Endocrinology and Metabolism

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A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5-2.0 cases/million per year and approximately 60% of CP is seen in adulthood. The therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. Typical initial manifestations at diagnosis in children are symptoms of elevated intracranial pressure, visual disturbances and hypopituitarism. CPs have the highest mortality of all pituitary tumours. The standardised overall mortality rate varies from 2.88 to 9.28 in cohort studies. Adults with CP have a 3-19-fold higher cardiovascular mortality in comparison to the general population. Women with CP have an even higher risk. The long-term morbidity is substantial with hypopituitarism, increased cardiovascular risk, hypothalamic damage, visual and neurological deficits, reduced bone health and reduction in quality of life and cognitive function.

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“…Primary and metastatic brain tumors may cause hypothermia. [4,[12][13][14][15] Autonomic neuropathy was suggested to define the role of the autonomic nervous system by the authors. [5,9] Another view is that the different drugs are associated with hypothermia.…”

Section: Discussionmentioning

confidence: 99%

“…In literature, this clinical manifestation has been reported from several case reports. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Herein we presented a case of stage IIIB Hodgkin's disease, complicating with hypothermia and hypotension after naproxen sodium administration.…”

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confidence: 99%

Hypothermia in Hodgkin’s disease: unexpected state; case report and rewiew of the literature

Gündoğ¹

2013

TJ Oncol

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Hipotermi ve hipotansiyon, etyolojisi bilinmeyen nadir bir fenomendir. Bu yazıda, hipertermi ile kendini gösteren, naproksen sodyum uygulaması sonrasında hipotermi gelişen evre IIIB Hodgkin hastalıklı bir olgu sunuldu. Bu olguda; naproksen uygulaması sonrası pirojenlerin üretiminin azalması, en muhtemel fizyopatolojik hipotez olarak gözükmektedir. Hipotermi daha kötü prognozla ilişkilendirilebilir. Literatürde-ki sonuçlara göre, biz hipotermi ve hipotansiyonun Hodgkin hastalığında henüz tanımlanmamış bir sendrom olabileceğini düşünüyoruz.Anahtar sözcükler: Hipotermi; hipotansiyon; naproksen sodyum; Hodgkin hastalığı.Hypothermia and hypotension is a rare phenomenon having uncertain etiology. We reported a case of stage IIIB Hodgkin's disease who developed hypothermia after naproxen sodium administration, initially presenting with hyperthermia. In this case, the reduction of pyrogens production after naproxen sodium administration, appears to be the most probable physiopathologic hypotheses. Hypothermia may correlate with worse prognosis. According to the outcomes of published cases in literature, we suspect that the hypothermia and hypotension may be an unidentified syndrome in Hodgkin's disease.

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Haematological, neurological and psychiatric complications of chronic hypothermia following surgery for craniopharyngioma

Cited by 27 publications

References 7 publications

Effects of Selective Brain Cooling in Patients with Severe Traumatic Brain Injury: A Preliminary Study

Effects of Selective Brain Cooling in Patients with Severe Traumatic Brain Injury: A Preliminary Study

Endocrine aspects and sequel in patients with craniopharyngioma

Hypothermia in Hodgkin’s disease: unexpected state; case report and rewiew of the literature

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