Haematological indices as predictors of atrial fibrillation following isolated coronary artery bypass grafting, valvular surgery, or combined procedures: a systematic review with meta-analysis

Weymann, Alexander; Ali-Hasan-Al-Saegh, Sadeq; Popov, Aron Frederik; Sabashnikov, Anton; Mirhosseini, Seyed Jalil; Liu, Tong; Tse, Gary; Lotfaliani, Mohammadreza; Ghanei, Azam; Testa, Luca; D’Ascenzo, Fabrizio; Benedetto, Umberto; Dehghan, Hamidreza; Roever, Leonardo; Sá, Michel Pompeu Barros de Oliveira; Baker, William L.; Yavuz, Şenol; Zeriouh, Mohamed; Mashhour, Ahmed; Nombela‐Franco, Luis; Jang, Jum Suk; Meng, Lei; Gong, Mengqi; Deshmukh, Abhishek; Palmerini, Tullio; Linde, Cecilia; Filipiak‬, Krzysztof J.; Biondi‐Zoccai, Giuseppe; Calkins, Hugh; Stone, Gregg W.

doi:10.5603/kp.a2017.0179

Cited by 57 publications

(53 citation statements)

References 23 publications

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“…One of the consequences is fibrosis, characterized by increased turnover of the extracellular matrix, producing conduction abnormalities that provide the necessary substrate for arrhythmogenesis . A number of blood biomarkers and electrocardiographic predictors have been found in association with AF onset, development, and recurrence. Of these, galectin‐3 plays a key role in acute and chronic pro‐inflammatory responses and mediates activation of quiescent fibroblasts and synthesis of collagen .…”

Section: Discussionmentioning

confidence: 99%

“…The end result is a pro‐arrhythmic substrate for arrhythmogenesis. As with other disorders, blood markers have been used for risk stratification purposes . More recently, galectin‐3, which is raised in the context of myocardial fibrosis, inflammation, and immune response activation, has emerged as a promising biomarker for risk stratification .…”

Section: Introductionmentioning

confidence: 99%

“…As with other disorders, blood markers have been used for risk stratification purposes. [2][3][4][5][6][7] More recently, galectin-3, which is raised in the context of myocardial fibrosis, inflammation, and immune response activation, has emerged as a promising biomarker for risk stratification. 8 A recent meta-analysis has demonstrated that galectin-3 provides incremental prognostic value that extends beyond that of traditional risk factors in the context of heart failure.…”

Section: Introductionmentioning

confidence: 99%

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Galectin‐3 and risk of atrial fibrillation: A systematic review and meta‐analysis

Gong

Cheung

Wang

et al. 2020

Clinical Laboratory Analysis

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Background Galectin‐3 is an inflammatory marker that is raised in myocardial fibrosis and inflammation. Recent studies have explored its role in predicting atrial fibrillation (AF) outcomes. The aim of this systematic review and meta‐analysis is to examine the association between serum concentration of galectin‐3 and AF. Methods PubMed, EMBASE, and the Cochrane Database were searched. A total of 280 studies were identified, of which 28 studies involving 10 830 patients were included in our meta‐analysis. Results Galectin‐3 is present at higher concentrations in patients with AF than those in sinus rhythm (mean difference [MD] = −0.68 ng/mL, 95% CI: −0.92, −0.44, Z = 5.61, P < .00001). Galectin‐3 levels were significantly higher in the persistent AF than in the paroxysmal AF group (MD = −0.94 ng/mL, 95% CI: −1.85, −0.03, Z = 2.04, P = .04). Higher galectin‐3 levels were associated with a 45% increase in the odds of developing AF (odds ratio [OR] = 1.45, 95% CI: 1.15, 1.83, Z = 3.11, P = .002) and risk of AF recurrence (hazard ratio [HR] =1.17, 95% CI: 1.06, 1.29, Z = 3.12, P = .002). Conclusions Our meta‐analysis found that galectin‐3 is significantly higher in patients with persistent AF than in those with paroxysmal AF, and can predict both AF development and recurrence after treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Galectin‐3 and risk of atrial fibrillation: A systematic review and meta‐analysis

Gong

Cheung

Wang

et al. 2020

Clinical Laboratory Analysis

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“…Different factors have been associated with the outcome stroke such as oxidation [17,18], inflammation [19][20][21][22], hyperglycemia [23], or alterations in brain perfusion due to blood pressure variability [24,25]. In addition, there has been found the association of RDW with oxidative stress in animal models [26], with blood TNF-alpha levels in critically ill patients [27,28], and with atrial fibrillation and its risk of complications and mortality [29][30][31]. Another novel finding of our study was that there is a positive association between RDW and blood levels of malondialdehyde and TNF-alpha during the first week of MMCAI.…”

Section: Discussionmentioning

confidence: 99%

Early Mortality of Brain Infarction Patients and Red Blood Cell Distribution Width

et al. 2020

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Background: Meta-analysis has found that high baseline red blood cell distribution width (RDW) is associated with increased long-term mortality (mortality at one year or more) in ischemic stroke. The objectives of this study were to determine whether there is an association between RDW and 30-day mortality, and to explore whether RDW during the first week of ischemic stroke could be a 30-day mortality biomarker. Methods: We included patients with malignant middle cerebral artery infarction (MMCAI). RDW at days 1, 4, and 8 of MMCAI were determined. The end-point study was 30-day mortality. Results: We found that survivor (n = 37) in respect to non-survivor patients (n = 37) had lower RDW at days 1 (p < 0.001), 4 (p < 0.001), and 8 (p = 0.02). The area under curve (95% CI) for prediction of 30-day mortality by RDW at days 1, 4, and 8 of MMCAI were 0.80 (0.69–0.89; p < 0.001), 0.79 (0.66–0.89; p < 0.001), and 0.73 (0.58–0.84; p = 0.02). Regression analysis showed an association between RDW (odds ratio = 1.695; 95% CI = 1.230–2.335; p < 0.001) and 30-day mortality. Conclusions: The association between RDW and early mortality, and the potential role of RDW during the first week of MMCAI as a prognostic biomarker of early mortality were the main novelties of our study.

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“…Haematological indices red blood cell distribution width (RDW) and mean platelet volume (MPV) are currently recognised as risk factors for POAF. MPV, as a valuable haematological parameter in complete blood count test, could strongly predict the occurrence of paroxysmal, persistent, or permanent AF [22-25] . Our study did not include aforementioned haematological parameters such as MPV and RDW.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effect of Preoperative Vitamin D Supplementation on Postoperative Atrial Fibrillation

Cerit¹,

Özçem²,

Cerit³

et al. 2018

Braz J Cardiovasc Surg

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ObjectiveTo assess the relationship between preoperative vitamin D (vitD) supplementation and the development of postoperative atrial fibrillation (POAF).MethodsThe study group consisted of 328 consecutive patients. The ınfluence of preoperative vitD supplementation on POAF was reviewed in 136 patients who underwent coronary artery bypass graft surgery with vitD insufficiency (n=80) and vitD deficiency (n=56). Patients were assigned to receive either oral vitD (50.000 U) (treatment group, n=68) or not (control group, n=68) 48 hours before surgery. Patients were followed up during hospitalisation process with respect to POAF.ResultsThere was no significant difference between treatment and control groups with regards to age, gender, diabetes mellitus, smoking history, chronic obstructive pulmonary disease, left atrial diameter, and biochemical parameters. Also, there was no significant difference between these groups with regards to mean vitD level on both insufficiency and deficiency patients (24.6±3.7 vs. 24.9±3.9 ng/ml P=0.837, 11.4±4.9 vs. 10.9±5.2 ng/ml P=0.681, respectively). Although the occurrence of POAF was not significantly different among treatment and control groups in patients with vitD insufficiency (31% vs. 33% P=0.538), there was a significant difference between the two groups regarding to POAF in patients with vitD deficiency (18% vs. 29% P=0.02).ConclusionAlthough preoperative vitD supplementation was not found to be associated with prevention of POAF in patients with vitD insufficiency, it was found to be strongly associated with prevention of POAF in those with vitD deficiency.

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Haematological indices as predictors of atrial fibrillation following isolated coronary artery bypass grafting, valvular surgery, or combined procedures: a systematic review with meta-analysis

Abstract: Haematological indices may predict the risk of POAF before surgery. These easily-performed tests should defi¬nitely be taken into account in patients undergoing isolated CABG, valvular surgery, or combined procedures.

Cited by 57 publications

References 23 publications

Galectin‐3 and risk of atrial fibrillation: A systematic review and meta‐analysis

Galectin‐3 and risk of atrial fibrillation: A systematic review and meta‐analysis

Early Mortality of Brain Infarction Patients and Red Blood Cell Distribution Width

Preventive Effect of Preoperative Vitamin D Supplementation on Postoperative Atrial Fibrillation

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