Haematological changes in fluorotic adults and children in fluoride endemic regions of Gaya district, Bihar, India

Yasmin, Shahla; Ranjan, Sumeet; D’Souza, Doris H.

doi:10.1007/s10653-013-9570-7

Cited by 14 publications

(6 citation statements)

References 11 publications

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“…In our present study, the serum F content was markedly higher in the three high F groups than that in the control group at 42 days of age (p < 0.01). The increased content of serum F was reported by many anthors [17]- [19]. Likewise, the content of urine F significantly increases in rat [20], rabbit [18] and fluorotic human [19] has been reported.…”

Section: Effects Of High Dietary F On the Content Of Serum F In Broilmentioning

confidence: 79%

“…The increased content of serum F was reported by many anthors [17]- [19]. Likewise, the content of urine F significantly increases in rat [20], rabbit [18] and fluorotic human [19] has been reported. Kono et al [21] reported that serum F concentrations in F-exposed workers with impaired renal function were strikingly higher than in other patients with chronic renal failure (CRF) and F-exposed workers.…”

Section: Effects Of High Dietary F On the Content Of Serum F In Broilmentioning

confidence: 79%

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Effects of High Dietary Fluoride on Serum Biochemistry and Oxidative Stress Parameters in Broiler Chickens

Deng¹,

Cui²,

Peng³

et al. 2014

Health

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The aim of this study was to investigate the effects of high dietary fluoride (F) on serum biochemistry and oxidative damage in broiler chickens. 280 one-day-old healthy avian broiler chickens were randomly allotted into four equal groups and fed with a corn-soybean basal diet containing 22.6 mg·F/kg (control group) or same basal diets supplemented with 400, 800, and 1200 mg·F/kg (high F groups I, II, and III) in the form of sodium fluoride for 42 days. At 42 days of age, the serum F content was markedly higher in the three high F groups than that in the control group. From 28 to 42 days of age, the contents of serum total protein (TP) and albumin (ALB) were significantly lower in the three high F groups. From 14 to 42 days of age, the activities of alkaline phosphatase (ALP), alanine aminotransferase (ALT) and the creatinine (Crea) contents in the serum showed a marked increase in the three high F groups; aspartate aminotransferase (AST) activity and uric acid (Ua) content were significantly increased, and a significant increase in the content of malondialdehyde (MDA) along with marked decreases in the activities of total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px), catalase (CAT), the glutathione (GSH) content and the ability to inhibit hydroxyl radical were observed in the high F groups II and III. In conclusion, F has accumulated in the blood circulatory system and dietary F in the range of 800 -1200 mg/kg could significantly induce abnormalities of bone, liver and kidney, inhibit the synthesis of protein, enhance lipid peroxidation and disturb the antioxidative system of broiler chickens.

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Section: Effects Of High Dietary F On the Content Of Serum F In Broilmentioning

confidence: 79%

Section: Effects Of High Dietary F On the Content Of Serum F In Broilmentioning

confidence: 79%

Effects of High Dietary Fluoride on Serum Biochemistry and Oxidative Stress Parameters in Broiler Chickens

Deng¹,

Cui²,

Peng³

et al. 2014

Health

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“…It is well established that fluoride damages not only hard tissues (teeth and bones) but also various soft tissues including blood cells. In recent studies, it has been concluded that excess fluoride exposure accelerates various hematological degenerations leading to erythrocyte death and anaemia [85][86][87]. In tribals, sickle cell disease and β-thalassaemia major are also fatal and cause varying degrees of anemia in tribal adults and children, respectively [25].…”

Section: Sickle Cell Anaemia (Hb-ss) and Fluoride Poisoning In Tribalsmentioning

confidence: 99%

How Do Sickle Cell Genes Protect Tribal People from Deadly Malaria? Is This a Type of Natural Selection?

Choubisa

2023

annhematoloncol

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In humans, genetic mutations have led to the formation of several haemoglobin (Hb) variants during human evolution. These mutations usually occur in the genes for a and Β- polypeptide or globin chains of haemoglobin located on chromosomes 11 and 16, respectively. Among these haemoglobin variants, sickle cell haemoglobin (Hb-S) is highly significant in the humans. In fact, this abnormal or mutant haemoglobin is the resultant of a point mutation in the gene for Β-globin, located on chromosome 11. No doubt, this sickle cell gene is relatively more prevalent among tribal people and widely distributed in those geographic regions where the dreaded Plasmodium falciparum-malaria is hyperendemic. In the human population, this mutant gene exists in two forms, the heterozygous (Hb-AS) and homozygous (Hb-SS) states. But this sickle cell gene is also found in association with other mutant genes of erythrocyte or red cell genetic disorders, such as abnormal Hb-C, Β-thalassemia, G-6-PD enzyme deficiency, etc. It is well known that tribal people generally live in forest ecosystem where dreaded malaria is also found to be endemic. How have these tribal people been able to protect themselves from this dreaded malaria for thousands of years in such a hostile environment, when they were most likely to be infected with the malaria parasite? Actually, its secret is hidden in these sickle cell genes only. Tribal individuals who have these genes in the heterozygous state (Hb-AS) do not get malaria or are protected from malaria and lead a healthy life. Several studies have confirmed that AS heterozygote people are protected against malaria. In contrast, those who have these genes in the homozygous (Hb-SS) state (homozygotes) develop sickle cell anaemia, which is fatal. Such patients die early due to severe malaria i.e AS heterozygotee individuals have a double advantages. In fact, it is a type of natural selection and also shows a balanced polymorphism in tribal people which is based on Darwin’s theory. This current communication provides factual and scientific information about the origin of sickle cell genes in the context of natural selection and how these genes protect tribal individuals from malaria. This communication is useful and important for zoologists, scientists working on human evolution, and medical scientists.

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“…Chronic F exposure for prolonged period destructs both hard (teeth and bones) and soft tissues including blood cells. Recently, in the study it has been claimed that excess ingestion of F for long-time or chronic F exposure from industrial F pollution causes various haematological degenerative changes leading to death of erythrocytes and causing mild to severe anaemia [104][105][106]. In the present tribal scheduled area, certain lethal erythrocyte genetic disorders such as sicklecell anaemia and β-thalassaemia major are also prevalent and causing mild to severe anaemia in adults and children, respectively [11].…”

Section: Impact Of Excess F Ingestionmentioning

confidence: 99%

A Brief Review of Sickle-Cell Haemoglobin, β-Thalassaemia and G-6-PD Deficiency Genes among Tribals of Scheduled Area of Rajasthan, India: Focus on Tribal Health

Choubisa

2021

J Biomed Res Environ Sci

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Rajasthan, situated at the north-western part of India is the biggest state in the country of India and has total of 33 districts. By merging eight tribal dominating districts namely, Banswara, Chittourgarh, Dungarpur, Pali, Pratapgarh, Rajasamand, Sirohi, and Udaipur of these, the government has created a special area called the ‘schedule area” in which >70% of the people are tribal. This area is mostly backward and underdeveloped where malaria is also hyperendemic. In this area, Bhil, Damor, Meena, Garasiya, Kathudia and Sahariya are the most dominating and major endogamous tribes. Besides the several communicable and non-communicable diseases in this area, certain erythrocyte genetic disorders, Sickle-Cell Haemoglobin (Hb-S), β-thalassaemia and G-6-PD deficiency (Gd) are also deteriorating the tribal health and causing morbidity and mortality in them. Genes of these red cell genetic disorders are more prevalent and widely distributed among tribal people. The maximum prevalence of these blood genetic disorders in tribes was found as 31.14%, 9.00% and 22.00%, respectively. Since the groundwater of this tribal area contains a high amount of Fluoride (F), drinking it poses a high risk of premature death of tribal people who already have homozygous state of sickle-cell and β-thalassaemic genes. In present communication, besides the focus on tribal health, the status of genes of sickle-cell haemoglobin, β-thalassaemia and G-6-PD deficiency in different tribal ethnic groups of scheduled area, the correlation of these blood genetic disorders with malaria, impact of F intoxication in tribal subjects possessing red cell genetic disorders and the prevention and control of these erythrocyte genetic disorders in tribal people have been critically reviewed. The results of this review are significant and advantageous in making and execution of prevention and control programme of these blood genetic disorders in tribals of scheduled area of Rajasthan, India. Moreover, in this review, research gaps are also highlighted for further research work.

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Haematological changes in fluorotic adults and children in fluoride endemic regions of Gaya district, Bihar, India

Cited by 14 publications

References 11 publications

Effects of High Dietary Fluoride on Serum Biochemistry and Oxidative Stress Parameters in Broiler Chickens

Effects of High Dietary Fluoride on Serum Biochemistry and Oxidative Stress Parameters in Broiler Chickens

How Do Sickle Cell Genes Protect Tribal People from Deadly Malaria? Is This a Type of Natural Selection?

A Brief Review of Sickle-Cell Haemoglobin, β-Thalassaemia and G-6-PD Deficiency Genes among Tribals of Scheduled Area of Rajasthan, India: Focus on Tribal Health

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