Haematological and biochemical reference values of <scp>G</scp>ambian infants

Odutola, Aderonke; Afolabi, Muhammed O.; Jafali, James; Baldeh, Ignatius; Owolabi, Olumuyiwa; Owiafe, Patrick K.; Bah, G.; Jaiteh, Boto; Mohammed, Nuredin; Donkor, Simon; Ndure, Jorjoh; Adetifa, Jane U.; Flanagan, Katie L.; Ota, Martin O. C.

doi:10.1111/tmi.12245

Cited by 15 publications

(19 citation statements)

References 25 publications

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“…Several African studies that have shown lower red blood cell indices in children and adults [16, 24, 25, 43] compared to American or European children [37]; we also observed this for Hb, Hct and MCV(Table 5 and S4 Table). This may be attributed to several factors that are common in the community, including malaria, other parasitic infestations [44, 45], haemoglobinopathies [46] and iron deficiency anaemia [47].…”

Section: Discussionsupporting

confidence: 85%

“…Creatinine and transaminases are generally comparable to that of Caucasians [16, 23, 24]. Similarly, studies in African children have typically shown that red blood cell parameters such as haemoglobin, haematocrit and mean corpuscular volume are lower than those of Caucasians, with the exception of platelets [25, 26] and eosinophils, which tend to be higher, the latter being attributed to helminth infestation.…”

Section: Introductionmentioning

confidence: 94%

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Clinical laboratory reference values amongst children aged 4 weeks to 17 months in Kilifi, Kenya: A cross sectional observational study

et al. 2017

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Reference intervals for clinical laboratory parameters are important for assessing eligibility, toxicity grading and management of adverse events in clinical trials. Nonetheless, haematological and biochemical parameters used for clinical trials in sub-Saharan Africa are typically derived from industrialized countries, or from WHO references that are not region-specific. We set out to establish community reference values for haematological and biochemical parameters amongst children aged 4 weeks to 17 months in Kilifi, Kenya. We conducted a cross sectional study nested within phase II and III trials of RTS, S malaria vaccine candidate. We analysed 10 haematological and 2 biochemical parameters from 1,070 and 423 community children without illness prior to experimental vaccine administration. Statistical analysis followed Clinical and Laboratory Standards Institute EP28-A3c guidelines. 95% reference ranges and their respective 90% confidence intervals were determined using non-parametric methods. Findings were compared with published ranges from Tanzania, Europe and The United States. We determined the reference ranges within the following age partitions: 4 weeks to <6 months, 6 months to less than <12 months, and 12 months to 17 months for the haematological parameters; and 4 weeks to 17 months for the biochemical parameters. There were no gender differences for all haematological and biochemical parameters in all age groups. Hb, MCV and platelets 95% reference ranges in infants largely overlapped with those from United States or Europe, except for the lower limit for Hb, Hct and platelets (lower); and upper limit for platelets (higher) and haematocrit(lower). Community norms for common haematological and biochemical parameters differ from developed countries. This reaffirms the need in clinical trials for locally derived reference values to detect deviation from what is usual in typical children in low and middle income countries.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 94%

Clinical laboratory reference values amongst children aged 4 weeks to 17 months in Kilifi, Kenya: A cross sectional observational study

et al. 2017

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“…When compared to reference intervals generated for infants, we observe that the reference intervals for haemoglobin, WBC T and differentials are comparable; the main difference being that those from this study but with slightly lower limits and wider range of values compared to infants and data from western countries compared in the paper [ 19 ]. The consistency of the data is also seen when compared to reference intervals for older children and adults which also showed similar trends for WBCs and haemoglobin and no association with gender [ 20 ].…”

Section: Discussionmentioning

confidence: 67%

Seasonal variation in haematological and biochemical reference values for healthy young children in The Gambia

et al. 2016

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BackgroundHaematological and biochemistry reference values for children are important for interpreting clinical and research results however, differences in demography and environment poses a challenge when comparing results. The study defines reference intervals for haematological and biochemistry parameters and examines the effect of seasonality in malaria transmission.MethodsBlood samples collected from clinically healthy children, aged 12–59 months, in two surveys during the dry and wet season in the Upper River region of The Gambia were processed and the data analysed to generate reference intervals based on the 2.5th and 97.5th percentiles of the data.ResultsAnalysis was based on data from 1141 children with median age of 32 months. The mean values for the total white cell count and differentials; lymphocyte, monocyte and neutrophil decreased with increasing age, were lower in males and higher in the wet season survey. However, platelet values declined with age (p < 0.0001). There was no evidence of effect of gender on mean values of AST, ALT, lymphocytes, monocytes, platelets and haemoglobin.ConclusionMean estimates for haematological and biochemistry reference intervals are affected by age and seasonality in the first five years of life. This consistency is important for harmonisation of reference values for clinical care and interpretation of trial results.Electronic supplementary materialThe online version of this article (doi:10.1186/s12887-016-0545-6) contains supplementary material, which is available to authorized users.

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“…Trends of age-specific differences in some parameters were also evident although this needs further verification in larger cohorts (Table 6). At present there are few reports available for adolescents and younger age groups, especially on biochemistry analytes in Africa [11,19,31,32]. …”

Section: Discussionmentioning

confidence: 99%

Hematological and Biochemical Data Obtained in Rural Northern Uganda

Palacpac

Ntege

Balikagala

et al. 2014

IJERPH

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Reference intervals for common hematological and clinical chemistry parameters constitute an important basis for health care. Moreover, with increasing priority in drug and vaccine development for infectious diseases in Africa, the first priority is the safety evaluation and tolerability of the candidate interventions in healthy populations. To accurately assess health status and address adverse events, clinical reference intervals in the target population are necessary. We report on hematological and biochemical indices from healthy volunteers who participated in a clinical trial in Lira, northern Uganda. Median and nonparametric 95% percentiles on five hematology and 15 biochemistry analytes are shown. Although most hematological analytes conformed to reported reference intervals and trends in Africa, literature review from different African countries highlight the need for a region-specific children reference interval that can be appropriate for the population.

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Haematological and biochemical reference values of Gambian infants

Cited by 15 publications

References 25 publications

Clinical laboratory reference values amongst children aged 4 weeks to 17 months in Kilifi, Kenya: A cross sectional observational study

Clinical laboratory reference values amongst children aged 4 weeks to 17 months in Kilifi, Kenya: A cross sectional observational study

Seasonal variation in haematological and biochemical reference values for healthy young children in The Gambia

Hematological and Biochemical Data Obtained in Rural Northern Uganda

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