Haematocytopathology: why?

Zeppa, Pio

doi:10.1111/j.1365-2303.2012.00972.x

Cited by 17 publications

(27 citation statements)

References 16 publications

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“…LN-FNAC can provide cytomorphological information and material for ancillary testing that is diagnostic, highlighting the key role of FNAC and other small biopsies in the evaluation of LAP. Despite the tremendous progress made in performing and interpreting LN-FNAC and its correlation with ancillary tests [2][3][4][5][6][7][8], the technique is not uniformly accepted by clinicians and pathologists [9][10][11]. This is mainly due to the lack of widely shared and accepted guidelines and a cytopathological classification that directly relates to management.…”

Section: Introductionmentioning

confidence: 99%

A Proposal for the Performance, Classification, and Reporting of Lymph Node Fine-Needle Aspiration Cytopathology: The Sydney System

et al. 2020

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Background: The evaluation of lymph nodes (LN) by fine-needle aspiration cytology (FNAC) is routinely used in many institutions but it is not uniformly accepted mainly because of the lack of guidelines and a cytopathological diagnostic classification. A committee of cytopathologists has developed a system of performance, classification, and reporting for LN-FNAC. Methods: The committee members prepared a document that has circulated among them five times; the final text has been approved by all the participants. It is based on a review of the international literature and on the expertise of the members. The system integrates clinical and imaging data with cytopathological features and ancillary techniques. The project has received the endorsement and patronage of the International Academy of Cytology and the European Federation of the Cytology Societies. Results: Clinical, imaging, and serological data of lymphadenopathies, indications for LN-FNAC, technical procedures, and ancillary techniques are evaluated with specific recommendations. The reporting system includes two diagnostic levels. The first should provide basic diagnostic information and includes five categories: inadequate/insufficient, benign, atypical lymphoid cells of undetermined/uncertain significance, suspicious, and malignant. For each category, specific recommendations are provided. The second diagnostic level, when achievable, should produce the identification of specific benign or malignant entities and additional information by utilizing ancillary testing. Conclusion: The authors believe that the introduction of this system for performing and reporting LN-FNAC may improve the quality of the procedure, the report, and the communication between cytopathologists and the clinicians. This system may lead to a greater acceptance and utilization of LN-FNAC and to a better interdisciplinary understanding of the results of this procedure.

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Section: Introductionmentioning

confidence: 99%

A Proposal for the Performance, Classification, and Reporting of Lymph Node Fine-Needle Aspiration Cytopathology: The Sydney System

et al. 2020

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“…FNAC of lymph nodes avoids unnecessary core needle biopsies (CNB) or excisional biopsies, reduces costs and complications, and reduces patients' anxiety by offering a rapid result, particularly with the use of rapid on-site evaluation (ROSE) [8][9][10]. FNAC of lymph nodes can be straightforward as in the case of specific infections and metastatic carcinomas or very complex as in many lymphomas [11,12].…”

Section: Introductionmentioning

confidence: 99%

Announcement: The International System for Reporting Lymph Node Cytopathology

et al. 2020

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Fine needle aspiration biopsy cytopathology (FNAC) of lymph nodes is a very common, inexpensive, and rapid diagnostic procedure and can lead to the accurate and timely diagnosis of one of the wide range of pathological processes that involve lymph nodes. These diagnoses include specific reactive processes, specific infections such as tuberculosis, metastatic carcinomas and melanomas, and some lymphomas. The FNAC effectively triages the lymph node material, but the initial diagnosis often requires ancillary testing as a second diagnostic step to make a specific diagnosis, such as the particular infectious agent, the type of lymphoma or Hodgkin lymphoma, or the specific type of metastatic malignancy. An international group of cytopathologists have begun the process of developing a system for the standardized reporting of lymph node FNAC. The group is addressing the pre-analytical issues related to the FNAC, including the role of clinical information and the use of ultrasound, and developing a structure of reporting categories based on the cytopathological findings linked to management recommendations. The basis of the system is the integration of the FNAC with the clinical setting, imaging, and ancillary tests that utilize the FNAC material, to produce a final report that will enhance patient care.

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“…[2][3][4][5]9,11,17,27,28 The two main limitations of HL FNAC diagnosis are: [2][3][4][5]9,11,17,27,28 The two main limitations of HL FNAC diagnosis are:…”

Section: Discussionmentioning

confidence: 99%

“…There are numerous reports and books describing FNAC findings of HL 2-17 but the FNAC diagnosis of HL is still controversial. [2][3][4][5]9,11,17,27,28 The two main limitations of HL FNAC diagnosis are:…”

Section: Discussionmentioning

confidence: 99%

CD15, CD30, and PAX5 evaluation in Hodgkin's lymphoma on fine‐needle aspiration cytology samples

Cozzolino

Vitagliano

Caputo

et al. 2019

Diagnostic Cytopathology

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Background: The phenotypical identification of diagnostic cells is crucial for the diagnosis of Hodgkin's lymphoma (HL) on fine-needle aspiration cytology (FNAC). The aim of this study is to evaluate the immunocytochemical (ICC) expression of CD30, CD15, and PAX5 in Hodgkin's cells (HC) and Reed-Sternberg cells (RSC) on smears and cell-blocks (CB) of HL and to compare the performance of each antibody on smears and CB.Methods: In 21 FNAC cases of histologically confirmed classical HL, ICC identification of HC and RSC was performed using CD15, CD30, and PAX5 on smears and CB, respectively.Results: CD30 was positive in 19/21 cases (90.5%; 11/11 smears and 8/10 CB), CD15 was positive in 14/21 cases (66.7%; 5/11 smears and 9/10 CB), and PAX5 was positive in 13/21 cases (61.9%; 9/11 smears and 4/10CB).Conclusions: CD15, CD30, and PAX5 are useful to the FNAC identification of HC and RSC. CD30 is the most sensitive, followed by CD15 and PAX5, which are more effective on CB and smears, respectively. K E Y W O R D SCD15, CD30, fine-needle aspiration cytology, Hodgkin lymphoma, PAX5

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Haematocytopathology: why?

Cited by 17 publications

References 16 publications

A Proposal for the Performance, Classification, and Reporting of Lymph Node Fine-Needle Aspiration Cytopathology: The Sydney System

A Proposal for the Performance, Classification, and Reporting of Lymph Node Fine-Needle Aspiration Cytopathology: The Sydney System

Announcement: The International System for Reporting Lymph Node Cytopathology

CD15, CD30, and PAX5 evaluation in Hodgkin's lymphoma on fine‐needle aspiration cytology samples

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