Haematinic deficiencies and patient clinical profiles in Polish patients with recurrent aphthous stomatitis (<scp>RAS</scp>)

Ślebioda, Zuzanna; Krawiecka, Ewa; Szponar, Elżbieta; Dorocka‐Bobkowska, Barbara

doi:10.1111/jop.12703

Cited by 13 publications

(6 citation statements)

References 18 publications

(29 reference statements)

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“…Some studies have suggested a significant relationship of RAU with the overall deficiency of vitamins and minerals [15,17,31,[33][34][35]; however, these differences dilute when each vitamin or mineral is separately studied [9,36]. Our results could not confirm the association of ulcers and vitamin B 12 deficiency, perhaps because the statistical analysis was performed considering the sole deficiency of this vitamin, or because several factors related to RAU could have been present simultaneously in our patients.…”

Section: Discussionmentioning

confidence: 60%

“…Our results could not confirm the association of ulcers and vitamin B 12 deficiency, perhaps because the statistical analysis was performed considering the sole deficiency of this vitamin, or because several factors related to RAU could have been present simultaneously in our patients. On the other hand, it may be possible that the importance of the association of nutritional deficiencies to RAU may be less than previously attributed to their etiopathogenesis, or that all the related factors may only be considered as precipitants for the development of aphthae, as suggested by other authors [9,17,37]. Some other causes such as vigorous tooth-brushing, the use of a hard tooth brush, anesthesia infiltration, or dental treatment may frequently trigger the development of RAU [38].…”

Section: Discussionmentioning

confidence: 97%

“…Local and systemic factors such as stress, hormones, trauma, microorganisms, food, food allergy [13], drugs, immunological diathesis, genetic predisposition [9], and nutritional deficiencies [14,15] seem to play an important role on the development of RAU [2,16]; additionally, the etiology of RAU has been considered multifactorial [17].…”

Section: Introductionmentioning

confidence: 99%

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Recurrent Aphthous Ulcers: Experience from a Tertiary Care Center

Esquivel-Pedraza

Fernández-Cuevas²,

Milke-García

et al. 2018

JDMS

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Background:The frequency of recurrent aphthous ulcers (RAU) and their relationship with comorbidities has been scarcely described. Methods:We conducted a retrospective analytical study of patients with a presumptive diagnosis of RAU, in order to know the frequency of misdiagnosis of RAU, to delineate the clinical and biochemical characteristics of RAU, and to analyze their correlation with systemic diseases. Three groups of recurrent ulcers were analyzed: a) RAU, b) RAU associated to Behçet´s disease, and c) other recurrent ulcers misdiagnosed as RAU (OU). We recorded clinical and laboratory data. Statistics included Mantel-Haenszel chi square test, Kruskall-Wallis test, and Student´s t test. Results: A total of 141 patients (106 women) were referred with a presumptive diagnosis of RAU: 56 cases (39.7%) with RAU; 10 (7.1%) with RAU in Behçet´s disease, and 75 (53.2%) with OU. RAU subjects presented a lower frequency of rheumatologic diseases than patients with Behçet´s disease ulcers [30.4% vs 70.0%; (p=0.03)] and patients with OU [30.4% vs 54.7%; (p=0.007)]. Additionally, immune deficiency was less common among patients with RAU in comparison to Behçet´s disease [3.6% vs 40.0%; (p=0.003)] and OU [3.6% vs 28.0%; (p‹0.001)]. Higher levels of serum leukocytes were seen in Behçet´s disease [median=8.9 (range 5.3-9.7) × 10 3 cells/mm 3 ] when compared to RAU [median=6.0 (range 3.2-21.2) × 10 3 cells/mm 3 ] and OU [median=6.0 (range 2.3-14.8) × 10 3 cells/mm 3 ] (p<0.04). Conclusions:Misdiagnosis of RAU was frequent; an individual pattern of association to specific groups of systemic diseases was observed in each studied group of recurrent ulcers. RAU and Behçet´s disease ulcers showed clinical and laboratory differences.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 97%

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Recurrent Aphthous Ulcers: Experience from a Tertiary Care Center

Esquivel-Pedraza

Fernández-Cuevas²,

Milke-García

et al. 2018

JDMS

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“…It is seen in otherwise healthy people, but also in various infectious and non-infectious diseases, including celiac disease (CD) [1,[6][7][8][9][10][11][12][13][14][15]. In addition, RAS is associated with genetic predisposition, iron and vitamin B12 deficiency, local mechanical injuries, stress, and hormonal imbalance [16,17,18]. We present an obese adolescent with RAS as the only clinical manifestation that indicated a CD.…”

Section: Introductionmentioning

confidence: 99%

Recurrent aphthous stomatitis as the only clinical sign of celiac disease in obese adolescent - case report and literature review

et al. 2020

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Introduction. Recurrent aphthous stomatitis (RAS) is a relatively common oral mucosal lesion of unclear etiology. It occurs in otherwise healthy people, but also in various infectious and non-infectious diseases, including celiac disease (CD). We present an obese adolescent with RAS as the only clinical sign of CD. Case outline. Adolescent aged 15 2/12 years come with very pronounced RAS in the last 5 months. He had no other difficulties. Obese from the age of 12. Other data without peculiarities. On admission, 165 cm tall (P25), obese (BMI 27 kg/m2), in the final stage of puberty, with stretch marks in the distal areas of the abdomen, thighs and gluteus and very pronounced pain-sensitive aphthae in the buccal and labial mucosa accompanied by swelling of the lips and perioral region. Except for lower serum iron levels (8 ?mol/l), routine laboratory blood tests were within the reference range. The serological test for CD was positive (antibodies to tissue transglutaminase IgA 78.5 U/ml, anti-endomysial antibodies IgA positive). Endoiscopy revealed reflux esophagitis, without any other pathological findings. Stereomicroscopic and pathohistological analysis of the duodenal mucosa samples showed mild destructive enteropathy (Marsh IIIa). Pathohistological examination of the gastric mucosa revealed grade I-II lymphocytic gastritis. The urease test for Helicobacter pylori was negative. A gluten-free diet resulted in the withdrawal of aphthous stomatitis and no recurrence later. Conclusion. Within the differential-diagnostic analysis of the RAS causes CB should be considered as well. Additionally, obesity does not exclude the presence of the CB.

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“…deficiencies, especially in iron, group B vitamins, vitamin C, folate, or zinc may contribute to RAS 18. If necessary, replacement therapies should be done.…”

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confidence: 99%

Approach to the aphthous lesions of the oral mucosa

Arıca

Ferhatosmanoğlu

2021

Mucosa

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Aphthous oral cavity lesions are common in clinical practice that negatively affect the quality of life. It is possible to reveal the etiological cause in aphthous lesions, with detailed history, physical examination findings, and appropriate laboratory evaluation. In this article, we aimed to review the differential diagnosis by examining the conditions that need to be questioned with clinical clues to reveal the correct etiological cause in a patient presenting with the complaint of oral aphthae.

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Haematinic deficiencies and patient clinical profiles in Polish patients with recurrent aphthous stomatitis (RAS)

Cited by 13 publications

References 18 publications

Recurrent Aphthous Ulcers: Experience from a Tertiary Care Center

Recurrent Aphthous Ulcers: Experience from a Tertiary Care Center

Recurrent aphthous stomatitis as the only clinical sign of celiac disease in obese adolescent - case report and literature review

Approach to the aphthous lesions of the oral mucosa

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