Haematidrosis and haemolacria in a young adult

Salas‐Alanís, Julio C.; Salas-Garza, Mauricio; Goldust, Mohamad; Fajardo-Ramírez, Óscar R

doi:10.1111/ced.14348

Cited by 4 publications

(7 citation statements)

References 5 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two articles suggest a possible genetic basis to the condition. 1,7 The most intriguing possibility comes from an article by Salas-Alanis et al identifying mutations in genes coding for the extracellular matrix (ECM). 7 Weakness in the ECM surrounding blood vessels and in the walls of blood vessels themselves may allow for RBCs to fill dermal defects and pass to the skin surface directly or through hair follicles.…”

Section: Discussionmentioning

confidence: 99%

“…1,7 The most intriguing possibility comes from an article by Salas-Alanis et al identifying mutations in genes coding for the extracellular matrix (ECM). 7 Weakness in the ECM surrounding blood vessels and in the walls of blood vessels themselves may allow for RBCs to fill dermal defects and pass to the skin surface directly or through hair follicles. Involvement of the sympathetic nervous system to raise blood pressure or increase vascular permeability to an extent that results in extravasation of blood into dermal defects may be supported by the success of treatment with beta-blockers.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a possible genetic predisposition to hematidrosis was proposed in two siblings with hematidrosis, and in a separate case, a 22-year-old man with the condition was identified as having mutations in multiple genes related to the extracellular matrix (ECM). 1,7…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pediatric hematidrosis – A case report and review of the literature and pathogenesis

Shafique

Hickman

Thorne

et al. 2021

Pediatric Dermatology

View full text Add to dashboard Cite

Hematidrosis is a disorder in which blood-tinged fluid exudes from uninjured skin or mucosa. It is often classified as an eccrine sweat disorder, though the precise mechanism-including involvement of sweat glands-has yet to be proven. In contemporary case reports, hematidrosis appears most frequently in the pediatric population, with 83% of cases in the literature since 2008 occurring in individuals 18 years old or younger. We present here a case of a 10-year-old girl with hematidrosis followed by a review of the literature, with an emphasis on the features of this condition in the pediatric population.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pediatric hematidrosis – A case report and review of the literature and pathogenesis

Shafique

Hickman

Thorne

et al. 2021

Pediatric Dermatology

View full text Add to dashboard Cite

show abstract

“…In some articles, the presence of the bloody tears was associated with a systemic disease such as underlying hemangiomas or meningiomas [29,30]. In some of the cases, the clinical manifestations appeared after traumatizing events; however, the magnitude of these events significantly varied between the cases, while some patients have been exposed to life threats [46], witnessed a violent death [5], or outlived a natural disaster [4], other detonates included familiar conflicts [18]. From the published cases, the median age was 23.51 years, with the youngest case being a newborn of only 11 days [42] and the oldest an 81-year-old patient [38].…”

Section: Resultsmentioning

confidence: 99%

“…Most of the cases were reported in India (20/60), USA (10/60), and Italy (5/60). Only 2 cases have been reported in Latin America [17,46] as well as other 2 in Africa [10,13]. The most common place of bleeding was the eyes (36), followed by the face (10) and ears (8), and uncommon places included the feet [32], eyelids [4], and axillae [48].…”

Section: Resultsmentioning

confidence: 99%

Hematohidrosis, Hemolacria, and “Trichorrhage”: A Systematic Review

Carrión-Álvarez

Castro

Salas-Garza

et al. 2022

Skin Appendage Disord

Self Cite

View full text Add to dashboard Cite

Introduction: Hematohidrosis and hemolacria are 2 conditions surrounded in religiousness, mysticism, and supernatural superstitions. While the mechanism is still unclear, these cases have amazed physicians for centuries. Methods: We performed a systematic review in PubMed from 2000 to mid-2021 accounting for 75 studies from which we included 60 cases in 53 articles which were described. Results: The median age of apparition was 24 years with the youngest case being 12 and the oldest 81. Some of the diseases were secondary to other causes such as hemangiomas and other neoplasias or epistaxis episodes. Most of the cases have been reported in India and the USA; most of them correspond to hemolacria alone (51.6%). Discussion: We have stated the basics of the substances involved in the coagulation process that have been described as genetically altered in some patients such as mucins, metalloproteinases, and fibrinogen, as well as propose a mechanism that can explain the signs of this particular entity and approach to its treatment as well as provide the first trichoscopy image of a patient with hemolacria.

show abstract

Hematohidrosis in 15th Century Renaissance Art and a Review of Modern Literature

Goh,

Wee,

Chua

et al. 2023

Semin Thromb Hemost

View full text Add to dashboard Cite

Hematohidrosis, or hematidrosis, is a rare medical condition characterized by blood oozing from the intact skin in the absence of a bleeding problem. 1 Prior to modern-day medical literature, these phenomena had been captured in Renaissance and also present-day artwork. While the purpose of medical literature is to aid healthcare professionals and patients in the better understanding and treatment of disease, a significant proportion of Renaissance art commissioned by the church depicted scenes from the Bible, for the purposes of a visual depiction of key events to promote teachings of the faith, and to encourage devotion to God.We explored the theme of hematohidrosis in historic art and performed a rapid review of modern medical literature, noting that the earliest works featuring hematohidrosis were depictions in Renaissance art as early as the 15th century. The German painter known as Meister Der Freisinger Passion (Master of the Freising Passion) depicts Jesus Christ in the Garden of Gethsemane at the foot of the Mount of Olives, sweating drops of blood (►Fig. 1). Around him, his disciples sit, fast asleep. Another piece given the same name, the Christus am Ölberg, is featured in one of the frescoes of the Tabernakelbildstock in Welsberg-Taisten (Wayside Shrine of Tesido; ►Fig. 2). Believed to have been painted by Wolfgang Sauber in the 1460s, it depicts Christ with his hands clasped together in prayer as bloody sweat dots his forehead. These two artworks provide visual testimony to Luke's account of the Gospel of Jesus Christ praying in the Garden of Gethsemane before crucifixion. The motif of the cup is featured in the two artworks, echoing Christ's words in Luke 22:42, "Father, if you are willing, remove this cup from me. Nevertheless, not My will, but Yours, be done." The cup is a symbol of the cup of God's wrath that Jesus takes upon Himself, as He takes on the sins of the nations. In the words of preacher Charles Spurgeon, "at one tremendous draught of love, He drank damnaarticle published online

show abstract

Haematidrosis and haemolacria in a young adult

Abstract: Click https://www.wileyhealthlearning.com/Activity/7114598/disclaimerspopup.aspx for the corresponding questions to this CME article.

Cited by 4 publications

References 5 publications

Pediatric hematidrosis – A case report and review of the literature and pathogenesis

Pediatric hematidrosis – A case report and review of the literature and pathogenesis

Hematohidrosis, Hemolacria, and “Trichorrhage”: A Systematic Review

Hematohidrosis in 15th Century Renaissance Art and a Review of Modern Literature

Contact Info

Product

Resources

About