“…An observational, longitudinal and prospective casecontrol study of COVID-19 breakthrough infections in vaccinated people, based on a prospective cohort of patients was carried out from February 1, 2021 to September 30, 2021, in a general medicine office in the Health Center Santa Maria de Benquerencia, Toledo (Spain), which has a list of 2,000 patients > 14 years of age (in Spain, the general practitioners [GPs] care for people > 14 years of age, except for exceptions requested by the child's family and accepted by the GP). The GPs in Spain work within the National Health System, which is public in nature, and are the gateway for all patients to the system, and each person is assigned a GP [26]. The number of residents of the neighbourhood that is treated at the Health Center, by 2020, was 22,553 people [27].…”