Habsburg

Judson, Pieter M.

doi:10.17104/9783406706547

Cited by 11 publications

(5 citation statements)

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“…The highest quality study to date of TKI is the international randomized clinical trial of cediranib vs placebo (CASPS), presented at the American Society of Clinical Oncology meeting in 2017 . Patients whose condition was worse by RECIST over the prior 6 months were randomized to cediranib, 30 mg/d orally, vs placebo.…”

Section: Resultsmentioning

confidence: 71%

“…As a summary of multiple sources, sunitinib demonstrated partial responses (PRs) in 19 patients and stable disease (SD) in up to 24 of 46 evaluable patients . For a TKI with a similar spectrum of activity, cediranib demonstrated 20 PRs (23%) and 46 SDs (53%) in 86 evaluable patients in different studies, including a phase 2 randomized trial of cediranib vs placebo . Pazopanib was associated with 1 complete response, 8 PRs, and 21 SDs, in 41 total evaluable patients …”

Section: Resultsmentioning

confidence: 99%

“…Median PFS was 10.8 months with cediranib vs 3.7 months with placebo (hazard ratio for PFS, 0.54; P = .04). The data provide the strongest evidence of the utility of TKIs in ASPS and support, at least in some aspects, the use of Food and Drug Administration–approved pazopanib in this diagnosis, since cediranib does not have regulatory approval as of 2018 . Overall, tyrosine kinase inhibitors show activity with either tumor responses or disease stabilization in more than 50% of the cases.…”

Section: Resultsmentioning

confidence: 99%

“…Alveolar soft-part sarcoma generally shows sensitivity to VEGFR-predominant TKIs compared with other STS subtypes, as shown in the CASPS trial, retrospective series, and case reports. Anecdotally, resistance to one VEGFR-predominant TKIs may not imply resistance to a different TKI; this variation may be due to the different spectrum of targets for each drug .…”

Section: Discussionmentioning

confidence: 99%

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Diagnosis, Prognosis, and Treatment of Alveolar Soft-Part Sarcoma

2019

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IMPORTANCE Alveolar soft-part sarcoma (ASPS) is a rare, translocation-driven sarcoma of the soft tissues. Alveolar soft-part sarcoma often affects young adults and is characterized by indolent behavior but early evidence of metastatic spread. After recognition of ASPS as a specific entity in 1952, retrospective data indicated prolonged survival in patients with metastases, despite inherent resistance to conventional doxorubicin-based chemotherapy. Tyrosine kinase inhibitors and immune checkpoint inhibitors have provided unexpected new treatment strategies for ASPS.OBSERVATIONS This review includes articles published between 1952 and March 1, 2018. With the introduction of new molecular diagnostic tools and therapies, the distinctive features of ASPS have become more evident. The identification and better understanding of molecular pathways activated by the characteristic t(X;17)(p11;q25) translocation and its correspondent chimeric ASPSCR1-transcription factor E3 (TFE3) fusion protein open new paths to drug development. The associations of TFE3 and facilitation of an immunosuppressive microenvironment provide a rationale for exploring treatments that affect the balance between T-effector cells and T-regulatory cells. Tyrosine kinase inhibitors, such as sunitinib, cediranib, and pazopanib, show activity with either tumor responses or disease stabilization in more than 50% of the cases. Given the association of new agents with patient outcomes, it is too early to say whether metastatic ASPS should still be considered incurable in all patients. CONCLUSIONS AND RELEVANCEThe biologic outcomes of the canonical genomic event in ASPS remain under investigation; a better understanding of the tumor microenvironment and the multiple pathways activated in this sarcoma, including unusual bioenergetics, MET signaling, and angiogenesis, should lead to more rational therapy. Basket trials and related prospective studies focusing on the intersection of specific signaling pathways and diseases with unique genomic features, such as ASPS, will provide an understanding of new options for care.

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Section: Resultsmentioning

confidence: 71%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Diagnosis, Prognosis, and Treatment of Alveolar Soft-Part Sarcoma

2019

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“…21 However, the ethnic identities were limited to the educated elites. 22 By the end of the nineteenth century, the former Frontier regions consisted mostly of Serbs except for eastern Croatia. In the latter there were also Czechs, Germans, Hungarians, Jews, Slovaks and Ukrainians.…”

Section: Historical Outlinementioning

confidence: 99%

Nationalising Scorched Earth - Memory and Destruction of Monuments from Vukovar to Knin

Piasek¹

2022

Studies on National Movements

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Research has often focused on Croatian memorialisation processes in specific places like Bleiburg and Jasenovac, controversial places during and after World War II. This article employs another view and elaborates on the destruction and removal, as well as the recent restoration of monuments and reconstruction of sacred architecture. It examines current memory processes in places once in the Republic of Serbian Krajina (1991-1995), from Vukovar to Knin. It stresses the different roles between state-organised and private commemorations in these historically multi-ethnic and -religious areas. The paper addresses problems like the demolition of monuments not fitting into the state narrative and analyses various historical processes that instigated the (re-)use of revisionist and mostly politically tolerated symbols and inscriptions on monuments and sacred architecture. With attention to the latter, it specifically deals with the reconstruction of a Catholic and Christian-Orthodox church in the Lika region. The research connects historical and anthropological approaches and contributes to the interdisciplinary field of memory studies.

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“Das Schulwesen aber ist und bleibet allezeit ein politicum”: The Felbiger General School Ordinance and School Reform in the Eighteenth-Century Habsburg Monarchy

Viehhauser

2019

School Acts and the Rise of Mass Schooling

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Habsburg

Cited by 11 publications

References 0 publications

Diagnosis, Prognosis, and Treatment of Alveolar Soft-Part Sarcoma

Diagnosis, Prognosis, and Treatment of Alveolar Soft-Part Sarcoma

Nationalising Scorched Earth - Memory and Destruction of Monuments from Vukovar to Knin

“Das Schulwesen aber ist und bleibet allezeit ein politicum”: The Felbiger General School Ordinance and School Reform in the Eighteenth-Century Habsburg Monarchy

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