Habituation and cortisol dysregulation in depression

Reus, Victor I.; Peeke, Harman V.S.; Miner, Caroline

doi:10.1016/0006-3223(85)90196-9

Cited by 28 publications

(11 citation statements)

References 23 publications

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“…Nonetheless, lower basal conductance levels and lower conductance amplitudes were detected in depressive patients, even after 1 month free of antidepressive drugs [19,33,34]. Moreover, Iacono et al [24] and William et al [35] compared depressive patients with antidepressive treatment to those without, finding no significant differences.…”

Section: Discussionmentioning

confidence: 96%

“…Thus, the habituation process does not appear to be affected in our depressives. Some researchers have shown faster habituation of electrodermal orientation responses in depressive patients [18][19][20][21][22][23][24][25]. Other studies have shown no or slower habituation in depressive patients 26,27].…”

Section: Discussionmentioning

confidence: 99%

“…For depressive patients electrodermal skin conductance has been regarded as the best autonomic activation index to detect arousal changes [17]. Faster habituation of electrodermal orientation responses has been demonstrated in depressive patients [18][19][20][21][22][23], even when the stimulus was a strong tone near the aversive threshold [24,25]. Nevertheless, in some studies depressive patients have shown no or slower habituation than normal [26,27].…”

mentioning

confidence: 99%

“…Iacono et al [24] found that depressive patients did not become dishabituated after a change in stimulus frequency. Reus et al [19] observed that while 75% of the normal subjects became dishabituated, only 38% of endogenous-depressive patients did.…”

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confidence: 99%

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Habituation and Sensitization Processes in Depressive Disorders

Miquel

Fuentes²,

García-Merita³

et al. 1999

Psychopathology

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The aim of the present study was to investigate further into habituation and sensitization processes in depressive disorders. The depressive subjects were 27 outpatients. All of them were diagnosed according to DSM-III-R criteria. Controls were 27 normal subjects. The amplitudes of electrodermal responses and the basal levels were recorded during a stimuli series of 15 80-dB tones and of 1 100-dB tone in the 11th trial. The depressive patients displayed lower basal conductance levels and lower conductance amplitudes in orienting responses to the first stimulus and to stimulus change. No differences were found in conductance response amplitudes of stimuli series, although a tendency towards smaller conductance amplitudes in depressive patients was observed before stimulus change. A trend towards habituation was detected in both groups, but no differences between them were present, neither the habituation velocity of depressives was found to be unlike normals. Our results display lower responsivity in depressive patients, which reflects alterations in the sensitization process.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Habituation and Sensitization Processes in Depressive Disorders

Miquel

Fuentes²,

García-Merita³

et al. 1999

Psychopathology

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“…Recent animal studies have indicated that maternal malnutritioninduced impairment of fetal programing of the HPA axis function is associated with adult-onset dysregulation of the axis (Chadio et al 2007, Rumball et al 2008, Buhl et al 2010. Dysregulation of the HPA axis function is the most common and consistently reported abnormality in depression (Reus et al 1985). In human studies, LBW has been shown to be related to alternations in HPA axis function in adult life, such as elevated basal morning cortisol levels, enhanced cortisol responses to ACTH or CRF challenge test, and increased urinary cortisol metabolite excretion (Levitt et al 2000, Ward et al 2004, de Rooij et al 2006.…”

Section: Introductionmentioning

confidence: 99%

Impaired miR449a-induced downregulation of Crhr1 expression in low-birth-weight rats

Nemoto

Kakinuma

Shibasaki

2014

Journal of Endocrinology

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Low birth weight (LBW) is related to increased incidence of common cardiovascular and metabolic disorders, and psychopathologies later in life. Recent studies have suggested that maternal malnutrition affects fetal hypothalamic-pituitary-adrenal (HPA) axis programing although the mechanism is unknown. We demonstrated that LBW offspring delivered from malnourished dams showed prolonged elevated plasma corticosterone concentrations when compared with those of normal-birth-weight (NBW) offspring and impaired downregulation of corticotropin-releasing factor receptor type 1 (CRF-R1, Crhr1) in the anterior pituitary in restraint. Restraint increased expression of miR449a, which we had previously demonstrated to be involved in Crhr1 downregulation, in the anterior pituitary and serum exosomal miR449a contents through glucocorticoids in NBW offspring, but not in LBW offspring. Although plasma corticosterone concentrations were higher at 2000 h than at 0800 h in both LBW and NBW offspring, they were significantly higher in LBW offspring than in NBW offspring at 2000 and 0200 h. There were no significant diurnal changes in miR449a expression levels in the anterior pituitary of either NBW or LBW offspring, but the expression was significantly lower in LBW offspring than in NBW offspring at 1400, 2000, and 0200 h. The expression levels of GAS5, which inhibits glucocorticoid receptor (GR) binding to glucocorticoid-responsive element, in the anterior pituitary of LBW offspring were elevated when compared with those of NBW offspring. The downregulation of GR found in NBW offspring did not occur in restrained LBW offspring. These results indicate that impaired miR449a expression, probably induced by increased GAS5 expression, causes dysregulation of Crhr1 expression in the anterior pituitary, resulting in prolonged HPA axis activation in restrained LBW offspring.

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The HPA System and Neuroendocrine Models of Depression

Kalin¹

1989

Animal Models of Depression

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Habituation and cortisol dysregulation in depression

Cited by 28 publications

References 23 publications

Habituation and Sensitization Processes in Depressive Disorders

Habituation and Sensitization Processes in Depressive Disorders

Impaired miR449a-induced downregulation of Crhr1 expression in low-birth-weight rats

The HPA System and Neuroendocrine Models of Depression

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