Habitual recreational physical activity is associated with significantly improved survival in cancer patients: evidence from the Roswell Park Data Bank and BioRepository

Cannioto, Rikki A.; Dighe, Shruti; Mahoney, Martin C.; Moysich, Kirsten B.; Sen, Arindam; Hulme, Karen; McCann, Susan E.; Ambrosone, Christine B.

doi:10.1007/s10552-018-1101-5

Cited by 20 publications

(16 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another point to consider that was extensively described earlier is that in our analysis, the insufficiently active group includes a mix of women who are completely inactive (no leisure-time physical activities) and insufficiently active. Previous studies have demonstrated that as little as one to two sessions of weekly exercise associate with significant survival advantages in cancer survivors in comparison with those who do nothing [25, 26]. Therefore, because these women are also included in our reference group, risk estimates for the comparison groups are likely to be attenuated or less significant than if we had only included women who were completely inactive.…”

Section: Discussionmentioning

confidence: 99%

Pre- to postdiagnosis leisure-time physical activity and prognosis in postmenopausal breast cancer survivors

et al. 2019

View full text Add to dashboard Cite

BackgroundPhysical activity (PA) before and after breast cancer diagnosis has been reported to be associated with lower mortality. However, whether changes in the activity after diagnosis impact prognosis is unclear and has not received much attention. This study aimed to examine pre- to postdiagnosis leisure-time PA and breast cancer prognosis.MethodsWe used data from the MARIE study, a prospective population-based patient cohort study of 3813 postmenopausal breast cancer patients, aged 50–74 at diagnosis, recruited from 2002 to 2005, re-interviewed in 2009, and followed up until June 2015. Prediagnosis PA was assessed at recruitment; postdiagnosis PA was assessed at re-interview in 2009. To examine pre- to postdiagnosis change in PA, women were categorized by pre- and postdiagnosis PA using a cut-off of 7.5 MET-h/week for meeting PA recommendations and combined into four groups: insufficiently active, increasingly active, decreasingly active, and sufficiently active. Cox regression models with delayed entry were used to assess associations between pre- to postdiagnosis patterns of PA and overall mortality (OM), breast cancer mortality (BCM), and recurrence-free survival (RFS). Additional analyses of pre- and postdiagnosis PA (no activity (reference), low activity, sufficient activity) with cancer outcomes, such as using a time-dependent model, were performed. In total, 2042 patients were included in the analyses.ResultsThere were 206 deaths (114 from breast cancer) after a median follow-up time of 6.0 years after the 2009 interview. Compared to insufficiently active women, increasingly active women were at lower risk of OM, BCM, and RFS (HR (95%CI) of 0.50 (0.31–0.82), 0.54 (0.30–1.00), 0.58 (0.40–0.84), respectively). In sufficiently active women, associations for OM (0.75 (0.48–1.15)), BCM (0.61 (0.33–1.13)), and RFS 0.80 (0.57–1.14)) were similar to increasingly active women but attenuated, and decreasingly active women were not at lower risk for OM (0.91 (0.61–1.36)), BCM (0.80 (0.45–1.42)), and RFS (1.04 (0.76–1.43)). In time-dependent analyses, sufficient activity vs. no activity was associated with better OM (0.73 (0.57–0.93)), BCM (0.64 (0.46–0.89)), and RFS (0.82 (0.68–0.99)). Low activity was not significantly associated with prognosis.ConclusionOur data support benefits for breast cancer prognosis in being physically active pre- and postdiagnosis particularly for women who were insufficiently active prediagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Pre- to postdiagnosis leisure-time physical activity and prognosis in postmenopausal breast cancer survivors

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Most studies have also indicated no survival associations with reflux [ 12 , 18 , 19 ], apart from a recent Scandinavian analysis reporting improved survival among symptomatic GERD patients [ 24 ]. A survival advantage was recently identified for physically active esophageal cancer patients [ 25 ], but was not reported in previous EAC-specific analyses [ 12 , 18 ]. Several studies have suggested that smoking and alcohol consumption are not associated with overall survival (OS) or EAC cancer-specific survival (CSS) [ 12 , 16 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 88%

Clinical and Lifestyle-Related Prognostic Indicators among Esophageal Adenocarcinoma Patients Receiving Treatment at a Comprehensive Cancer Center

Dighe

Yan

Mukherjee

et al. 2021

Cancers

Self Cite

View full text Add to dashboard Cite

Purpose: The incidence of esophageal adenocarcinoma (EAC) has risen substantially in recent decades, while the average 5-year survival remains only ~20%. Disease stage and treatment are the strongest prognostic factors. The role of lifestyle factors in relation to survival remains uncertain, with a handful of studies to date investigating associations with obesity, smoking, physical activity, diet, or medications. Methods: This study included patients diagnosed with primary adenocarcinoma of the esophagus, gastroesophageal junction, or cardia (N = 371) at Roswell Park Comprehensive Cancer Center between 2003 and 2019. Leveraging extensive data abstracted from electronic medical records, epidemiologic questionnaires, and a tumor registry, we analyzed clinical, behavioral, and environmental exposures and evaluated stage-specific associations with survival. Survival distributions were visualized using Kaplan–Meier curves. Cox proportional hazards regression models adjusted for age, sex, stage, treatment, and comorbidities were used to estimate the association between each exposure and all-cause or cancer-specific mortality. Results: Among patients presenting with localized/regional tumors (stages I–III), current smoking was associated with increased overall mortality risk (HR = 2.5 [1.42–4.53], p = 0.002), while current physical activity was linked to reduced risk (HR = 0.58 [0.35–0.96], p = 0.035). Among patients with stage IV disease, individuals reporting pre-diagnostic use of statins (HR = 0.62 [0.42–0.92], p = 0.018) or NSAIDs (HR = 0.61 [0.42–0.91], p = 0.016) had improved overall survival. Exploratory analyses suggested that high pre-diagnostic dietary consumption of broccoli, carrots, and fiber correlated with prolonged overall survival in patients with localized/regional disease. Conclusion: Our data suggest that lifestyle exposures may be differentially associated with EAC survival based on disease stage. Future investigation of larger, diverse patient cohorts is essential to validate these findings. Our results may help inform the development of lifestyle-based interventions to improve EAC prognosis and quality of life.

show abstract

“…Other studies have confirmed these findings [ 167 ]. Analysis of data from 5807 patients enrolled in the Roswell Park Comprehensive Cancer Center Shared Resource, the Data Bank and BioRepository, showed that habitual physical activity was associated with enhanced survival among patients with a number of cancers, including bladder, breast, colorectal, esophageal, prostate, skin, endometrial (uterine), and ovarian cancers [ 168 ]. Importantly, there was reduced risk among patients who had been physically inactive prior to diagnosis but began exercising after learning of their cancer.…”

Section: Exercisementioning

confidence: 99%

Stress reduction strategies in breast cancer: review of pharmacologic and non-pharmacologic based strategies

et al. 2020

View full text Add to dashboard Cite

Breast cancer is the most common cancer diagnosed in women. It is associated with multiple symptoms in both patients and caregivers, such as stress, anxiety, depression, sleep disturbance, and fatigue. Stress appears to promote cancer progression via activation of the sympathetic nervous system releasing epinephrine and norepinephrine as well as activation of hypothalamic-pituitary-adrenal axis releasing cortisol. These stress hormones have been shown to promote the proliferation of cancer cells. This review focuses on stress-reducing strategies which may decrease cancer progression by abrogating these pathways, with a main focus on the β-adrenergic signaling pathway. Patients utilize both non-pharmacologic and pharmacologic strategies to reduce stress. Non-pharmacologic stress-reduction strategies include complementary and alternative medicine techniques, such as meditation, yoga, acupuncture, exercise, use of natural products, support groups and psychology counseling, herbal compounds, and multivitamins. Pharmacologic strategies include abrogating the β2-adrenergic receptor signaling pathway to antagonize epinephrine and norepinephrine action on tumor and immune cells. β-Blocker drugs may play a role in weakening the pro-migratory and pro-metastatic effects induced by stress hormones in cancer and strengthening the anti-tumor immune response. Preclinical models have shown that non-selective β1/2-blocker use is associated with a decrease in tumor growth and metastases and clinical studies have suggested their positive impact on decreasing breast cancer recurrence and mortality. Thus, non-pharmacological approaches, along with pharmacological therapies part of clinical trials are available to cancer patients to reduce stress, and have promise to break the cycle of cancer and stress.

show abstract

Habitual recreational physical activity is associated with significantly improved survival in cancer patients: evidence from the Roswell Park Data Bank and BioRepository

Cited by 20 publications

References 43 publications

Pre- to postdiagnosis leisure-time physical activity and prognosis in postmenopausal breast cancer survivors

Pre- to postdiagnosis leisure-time physical activity and prognosis in postmenopausal breast cancer survivors

Clinical and Lifestyle-Related Prognostic Indicators among Esophageal Adenocarcinoma Patients Receiving Treatment at a Comprehensive Cancer Center

Stress reduction strategies in breast cancer: review of pharmacologic and non-pharmacologic based strategies

Contact Info

Product

Resources

About