Habitual physical activity is associated with endothelial function and endothelial progenitor cells in patients with stable coronary artery disease

Luk, Ting-Hin; Dai, Yuk-Ling; Siu, Chung‐Wah; Yiu, Kai‐Hang; Chan, H. S.; Fong, Daniel Yee Tak; Lee, Stephen W.L.; Li, Sheung-Wai; Tam, Sidney; Lau, Chu‐Pak; Tse, Hung‐Fat

doi:10.1097/hjr.0b013e32832b38be

Cited by 40 publications

(36 citation statements)

References 38 publications

(72 reference statements)

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“…In addition, exercise training has been suggested to improve vasomotor function (eg, coronary dilation), providing the possibility of increased myocardial oxygen delivery to cardiac muscle and thereby potentially increased stroke volume. 528,529 Submaximal cardiac output might be lower at a given workload, primarily the result of lower HR, with maintenance of Vȯ 2 provided by a widening of peripheral arteriovenous Vȯ 2 difference after training. This suggests improved overall efficiency for delivery of oxygen to the tissues.…”

Section: Peak Oxygen Uptakementioning

confidence: 99%

Exercise Standards for Testing and Training

Fletcher¹,

Ades²,

Kligfield³

et al. 2013

Circulation

1,637

760

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Section: Peak Oxygen Uptakementioning

confidence: 99%

Exercise Standards for Testing and Training

Fletcher¹,

Ades²,

Kligfield³

et al. 2013

Circulation

1,637

760

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“…4,5 Furthermore, it has been reported that a higher level of habitual physical activity level (PAL) is associated with improved endothelial function in patients with CAD. 6 Recent studies have highlighted the potential link between mitochondrial dysfunction and the pathogenesis of atherosclerosis. Cardiovascular risk factors such as hypercholesterolemia 7 and diabetes mellitus 8 induce mitochondrial dysfunction, leading to an overproduction of reactive oxygen species (ROS).…”

mentioning

confidence: 99%

Association of Lower Habitual Physical Activity Level With Mitochondrial and Endothelial Dysfunction in Patients With Stable Coronary Artery Disease

Luk

Dai

Siu

et al. 2012

Circ J

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Background:Exercise training improves endothelial function in patients with coronary artery disease (CAD) through unclear mechanisms. We hypothesized that mitochondrial dysfunction related to a lower habitual physical activity level (PAL) is associated with endothelial dysfunction. Methods and Results:We assessed habitual PAL by a validated International Physical Activity Questionnaire, brachial flow-mediated dilation (FMD) and serum lactate, pyruvate, fasting glucose and lipid profiles in 105 CAD patients (age 68±10; 87% men). As defined by the lactate/pyruvate ratio (LP ratio) ≥75 th percentile of the age-and sex-matched controls (ie, ≥18), mitochondrial dysfunction was observed in 33/105 (31%) patients. With decreasing PAL tertiles, there were significant linear trends of lower FMD (P=0.004) and higher LP ratio (P=0.009). Multivariate logistic regression found that the lowest compared with the highest PAL tertile (adjusted odds ratio=3.78, P=0.02) had more patients with high LP ratio. After adjustment for cardiovascular risk factors and medications, the lowest compared to the highest PAL tertile had significantly lower FMD (absolute decrease 1.25%, P=0.03); and high LP ratio was associated with impaired FMD (absolute reduction 1.09%, P=0.03). Conclusions:In CAD patients, a lower level of habitual PAL is associated with impaired FMD and increased prevalence of mitochondrial dysfunction as defined by high LP ratio. Moreover, high LP ratio predicts a lower FMD, suggesting that the occurrence of mitochondrial dysfunction with lower habitual PAL is associated with endothelial dysfunction in CAD patients. (Circ J 2012; 76: 2572 - 2578

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“…Exercise may also halt atherosclerotic disease progression as ascertained in both the coronary and carotid beds (Belardinelli, Paolini et al 2001;Hambrecht, Walther et al 2004;Rauramaa, Halonen et al 2004). While multiple studies have shown exercise to mobilize EPCs, the total amount of physical activity has been associated directly with EPC numbers which is consistent with a dose-response (Adams, Lenk et al 2004;Sandri, Adams et al 2005;Luk, Dai et al 2009). Of great interest is the intensity of exercise required to mobilize EPCs.…”

Section: Physical Activitymentioning

confidence: 56%