Habitual Intake of Guaraná and Metabolic Morbidities: An Epidemiological Study of an Elderly Amazonian Population

Krewer, Cristina da Costa; Ribeiro, Euler Esteves; Ribeiro, Ednéa Aguiar Maia; Moresco, Rafael Noal; Rocha, Maria Izabel de Ugalde Marques da; Montagner, Greice Franciele Feyl dos Santos; Machado, Michel Mansur; Viégas, Karin; Brito, E. Millán; Cruz, Ivana Beatrice Mânica da

doi:10.1002/ptr.3437

Cited by 40 publications

(34 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vivo, it has been shown that Camellia sinensis may have beneficial effects against obesity [23,24]. Guarana exhibited a protector effect against hypertension, obesity and metabolic syndrome in elderly healthyvolunteers [8], and contributed to lower food intake in obese subjects [10]. Furthermore, the potential therapeutic role of guarana was demonstrated in atherosclerosis.…”

Section: Resultsmentioning

confidence: 99%

“…Guarana has been associated with protection against hypertension, obesity and metabolic syndrome in elderly healthy volunteers [8]. Additionally, a therapeutic role in atherosclerosis has been described [9].…”

Section: Introductionmentioning

confidence: 99%

“…Although some in vitro [11] and human studies [8,10] indicate the anti-adipogenic potential of guarana, its effects on adipogenesis have not been evaluated. Here, we are able to show that guarana exerts its anti-adipogenic activity through the modulation of both: the expression of master regulators of adipogenesis, and the activation of the Wnt pathway.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Modulatory Effects of Guarana (Paullinia cupana) on Adipogenesis

Lima¹,

Numata²,

Mesquita

et al. 2017

Nutrients

View full text Add to dashboard Cite

Guarana (Paullinia cupana) is a plant originated in Brazil that presents a beneficial effect on body weight control and metabolic alterations. The aim of this study was to evaluate the effects of guarana on genes and miRNAs related to adipogenesis in 3T3L1 cells. The anti-adipogenic effect of guarana was evaluated by Oil Red-O staining. Gene and miRNA expression levels were determined by real time PCR. The Cebpα and β-catenin nuclear translocation were evaluated using immunocytochemistry. Our data indicated that the triglyceride-reducing effect of guarana was dose-dependent from 100 to 300 µg/mL (−12%, −20%, −24% and −40%, respectively, p < 0.0001). An up-regulation of the anti-adipogenic genes Wnt10b, Wnt3a, Wnt1, Gata3 and Dlk1 and a down-regulation of pro-adipogenic genes Cebpα, Pparγ and Creb1 were also observed. Furthermore, guarana repressed mmu-miR-27b-3p, mmu-miR-34b-5p and mmu-miR-760-5p, that contributed for up-regulation of their molecular targets Wnt3a, Wnt1 and Wnt10b. Additionally, cells treated with guarana presented an increase on β-catenin nuclear translocation (p < 0.0018). In summary, our data indicate that guarana has an anti-adipogenic potential due to its ability to modulate miRNAs and genes related to this process. Together our data demonstrate the important role of guarana as a putative therapeutic agent.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modulatory Effects of Guarana (Paullinia cupana) on Adipogenesis

Lima¹,

Numata²,

Mesquita

et al. 2017

Nutrients

View full text Add to dashboard Cite

show abstract

“…The influence of routine guarana consumption on apparent tolerance to mercury intoxication has been proposed (9, 10, 34). The present study investigated the effects of pre-treatment with guarana ethanolic extract (GEE) on L4-larvae stage C. elegans exposed to MeHg for 6 hours.…”

Section: Discussionmentioning

confidence: 99%

Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans

et al. 2016

View full text Add to dashboard Cite

The influence of routine guarana (Paullinia cupana) consumption on apparent tolerance to mercury intoxication has been proposed. The present study investigated this hypothesis in Caenorhabditis elegans, a suitable experimental model for studies in toxicology. Wild type (WT) and skn-1 (ok2315) worm strains were pretreated with guarana ethanolic extract (GEE) from larvae 1 (L1) to L4 stage and then exposed for 6 hours to methylmercury (MeHg). The analyses included evaluation of GEE’s effects on lethality, developmental delay, feeding, locomotion, gene expression (sod-3, gst-4, sir-2.1, hsf-1, snn-1, mtl-1, mtl-2, aat-1, aat-2 and aat-3) and antioxidant activity. GEE pre-treatment had no aberrant effects on WT worms exposed to MeHg, and protected skn-1 (ok2315) worms, which are more susceptible to environmental stresses. Protective effects of GEE might be dependent on modulation of genes other than those directly involved in antioxidant activity. GEE increased the expression of genes involved in metal transport (aat-2), metal detoxification (mtl-1 and mtl-2) and antioxidant responses (sir-2.1 and sod-3). Thus, routine consumption of guarana might be beneficial in protecting against MeHg-induced toxicity.

show abstract

“…Furthermore, guarana also plays an important role in the treatment of cardiovascular diseases, promoting a reduction in blood pressure levels and LDL fraction in an elderly population residing in the Amazon region [10]. …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antibacterial, Antineoplastic, and Immunomodulatory Activity ofPaullinia cupanaSeeds Crude Extract and Ethyl-Acetate Fraction

Carvalho

Cordeiro

Lins

et al. 2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Paullinia cupana (Guarana) is a native plant of Amazon region that has very traditional importance. Its seeds are rich in bioactive compounds, including tannins, which exhibit relevant properties. Objective. This study aimed to evaluate antibacterial, antineoplastic, and immunomodulatory activity of P. cupana seeds crude extract (CE) and ethyl-acetate fraction (EAF). Methods. Antibacterial activity was evaluated by determination of minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). Antineoplastic activity was evaluated by MTT assays in hepatocellular carcinoma (HepG2), breast adenocarcinoma (MCF-7), ductal carcinoma (T47-D), non-Hodgkin's B cell lymphoma (Toledo), T cell leukemia (Jukart), and Acute Leukemia (HL-60) cell lines. BALB/c mice splenocytes were treated to assess IFN-γ, IL-6, IL-17, and IL-10 levels by sandwich ELISA. Results. CE and EAF were not toxic to peripheral blood cells and splenocytes. CE and EAF fractions showed a bacteriostatic activity (MIC = 250 μg/mL) and presented IC50 values of 70.25 μg/mL and 61.18 μg/mL in HL-60 leukemia cell line. All cytokines evaluated had their levels reduced after treatment, following dose-response model. Discussion and Conclusion. Different biological activities were observed for both CE and EAF, suggesting P. cupana as a source of bioactive substances, especially tannins that may be used for several diseases treatments.

show abstract

Habitual Intake of Guaraná and Metabolic Morbidities: An Epidemiological Study of an Elderly Amazonian Population

Cited by 40 publications

References 50 publications

Modulatory Effects of Guarana (Paullinia cupana) on Adipogenesis

Modulatory Effects of Guarana (Paullinia cupana) on Adipogenesis

Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans

Evaluation of Antibacterial, Antineoplastic, and Immunomodulatory Activity ofPaullinia cupanaSeeds Crude Extract and Ethyl-Acetate Fraction

Contact Info

Product

Resources

About