Habitual fish intake negatively correlates with prevalence of frailty among patients with rheumatoid arthritis

Minamino, Hiroto; Katsushima, Masao; Torii, Mie; Hashimoto, Motomu; Fujita, Yoshihito; Ikeda, Kaori; Yamamoto, Wataru; Watanabe, Ryu; Murakami, Kosaku; Murata, Koichi; Nishitani, Kohei; Tanaka, Masao; Ito, Hiromu; Ohmura, Koichiro; Arai, Hidenori; Inagaki, Nobuya; Matsuda, Shinya

doi:10.1038/s41598-021-84479-0

Cited by 14 publications

(33 citation statements)

References 34 publications

(29 reference statements)

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“…One study, using CDAI, found that this relationship was no longer evident after adjusting for age 33 . In contrast, two other studies, showed that frailty remained associated with a higher baseline DAS-28 score after adjustment for age, sex, duration of rheumatoid arthritis and physical impairment (quantified using the Health Assessment Questionnaire -Disability Index (HAQ-DI)) 25,27 .…”

Section: Rheumatoid Arthritis Disease Activitymentioning

confidence: 88%

“…Ten studies, using seven different frailty measures and four different markers of rheumatoid arthritis disease activity (four using Disease Activity Score in 28 joints, two using the Rheumatoid Arthritis Disease Activity Index, two using Simple Disease Activity Index and two using Clinical Disease Activity Index) all showed a significant cross-sectional association between frailty status and activity of rheumatoid arthritis before adjustment for additional factors 10,11,20,21,25,[27][28][29][30]33 . One study, using CDAI, found that this relationship was no longer evident after adjusting for age 33 .…”

Section: Rheumatoid Arthritis Disease Activitymentioning

confidence: 99%

“…Seven studies assessed the relationship between frailty and physical function using the HAQ-DI 11,12,21,22,25,27,28,30,33 . Each of these studies demonstrates an association between frailty and higher baseline HAQ scores (indicating a greater degree of physical impairment).…”

Section: Physical Functionmentioning

confidence: 99%

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Frailty in people with rheumatoid arthritis: a systematic review of observational studies

et al. 2021

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Background: Frailty, an age-related decline in physiological reserve, is an increasingly important concept in the management of chronic diseases. The implications of frailty in people with rheumatoid arthritis are not well understood. We undertook a systematic review to assess the prevalence of frailty in people with rheumatoid arthritis, and the relationship between frailty and clinical outcomes. Methods: We searched three electronic databases (January 2001 to April 2021) for observational studies assessing the prevalence of frailty in adults (≥18 years) with rheumatoid arthritis, or analysing the relationship between frailty and clinical outcomes in the context of rheumatoid arthritis. Titles, abstracts and full texts were assessed independently by two reviewers. Study quality was assessed using an adapted Newcastle-Ottawa Scale. Results: We identified 17 analyses, from 14 different sample populations. 15/17 were cross-sectional. These studies used 11 different measures of frailty. Frailty prevalence ranged from 10% (frailty phenotype) to 36% (comprehensive rheumatologic assessment of frailty) in general adult populations with rheumatoid arthritis. In younger populations (<60 or <65 years) prevalence ranged from 2.4% (frailty phenotype) to 19.9% (Kihon checklist) while in older populations (>60 or >65) prevalence ranged from 31.2% (Kihon checklist) to 55% (Geriatric 8 tool). Frailty was associated with higher disease activity (10/10 studies), lower physical function (7/7 studies), longer disease duration (2/5 studies), hospitalization (1/1 study) and osteoporotic fractures (1/1 study). Conclusion: Our review found that frailty is common in adults with rheumatoid arthritis, including those aged <65 years, and is associated with a range of adverse features. However, these is substantial heterogeneity in how frailty is measured in rheumatoid arthritis. We found a lack of longitudinal studies making the impact of frailty on clinical outcomes over time and the extent to which frailty is caused by rheumatoid arthritis unclear.

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Section: Rheumatoid Arthritis Disease Activitymentioning

confidence: 88%

Section: Rheumatoid Arthritis Disease Activitymentioning

confidence: 99%

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Frailty in people with rheumatoid arthritis: a systematic review of observational studies

et al. 2021

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“…Each one rheumatologist per patient assessed and recorded RA disease activity including 28 tender and swollen joint sites in a template for electronic charts on every visit, and the obtained data were integrated with blood tests and other clinical information. We recruited female RA outpatients from the KURAMA cohort database [ 24 ]. Participants were enrolled from May 2014 to December 2014 who visited the Kyoto University Hospital, were over 18 years old, and met the diagnostic criteria of the ACR/EULRA RA classification [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Influence of dietary habits on depression among patients with rheumatoid arthritis: A cross-sectional study using KURAMA cohort database

et al. 2021

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Objective Although mental disorder is one of the most common comorbidities of rheumatoid arthritis (RA) and is known as a critical influence on RA remission rates, there is little knowledge regarding a possible therapeutic strategy for depression or anxiety in a RA population. Most recently, clinical evidence of dietary improvement for depression has emerged in a general population, but the relationship between dietary habits and mental disorder has not been investigated in RA. The purpose of this study is to elucidate clinical associations between mental disorder (depression/anxiety), dietary habits and disease activity/physical function in patients with RA. Methods A cross-sectional study was performed with 267 female outpatients from the KURAMA database. Using the Hospital Anxiety and Depression Scale (HADS), we classified the participants into three groups by depression state, and their characteristics were compared. Using the 20-items on the self-reported food frequency questionnaire, we investigated the relationship between dietary habits and depression or anxiety, adopting a trend test and a multivariate standardized linear regression analysis for the HADS score of depression or that of anxiety as a dependent variable. Results According to the classified stage of depression, current disease activity (DAS28-CRP: 28-Joint RA Disease Activity Score-C-reactive protein) and the health assessment questionnaire disability Index (HAQ-DI) were significantly increased. Trend analyses revealed that the depression score was inversely associated with the consumption of three food (fish, vegetables and fruit) out of twenty as was the anxiety score with only fish intake. Furthermore, multiple linear regression analysis revealed that the depression score was negatively associated with frequent fish intake (≥ 3 times per week) (Estimate -0.53, p = 0.033), HAQ-DI score within normal range (Estimate -0.88, p ≤ 0.001) and MTX use (Estimate -0.60, p ≤ 0.023). For the anxiety score, multivariate analysis showed similar but not significant associations with variables except for HAQ-DI score. Conclusions In a RA population, both depression and anxiety had a significant and negative association with HAQ-DI score, and depression rather than anxiety had negative association with frequent fish intake. Modification of dietary habits such as increased fish consumption may have a beneficial effect on the depression state in RA patients.

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“…We measured muscle mass, muscle strength and physical performance to assess sarcopenia status in the study population, as previously described 10,22 . Skeletal muscle mass was measured by bioelectrical impedance analysis (Inbody 720: Biospace Co., Ltd., Seoul, Korea).…”

Section: Diagnosis Of Sarcopenia and Estimation Of The Related Parametersmentioning

confidence: 99%

Influence of serum vitamin D status on severe sarcopenia among female patients with rheumatoid arthritis: the KURAMA database

Minamino¹,

Katsushima²,

Torii³

et al. 2021

Preprint

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Sarcopenia is an age-related disease with an increased risk of mortality. It is emerging that low serum vitamin D (25(OH)D) affects the sarcopenic state in general, but in rheumatoid arthritis (RA), these associations are not understood although the prevalence of vitamin D insufficiency is high in RA. We conducted a cross-sectional study of older female outpatients from our cohort (KURAMA) database. We measured skeletal muscle mass, handgrip strength, and gait-speed to diagnose severe sarcopenia. The serum 25(OH)D concentration was measured using electrochemiluminescence immunoassay. A total of 156 Patients (sarcopenia:44.9%, severe sarcopenia: 29.5%, and without sarcopenia: 25.6%) were enrolled. Classification of vitamin D status at a cutoff point of median 25(OH)D concentration revealed that low 25(OH)D status was associated with a high prevalence of severe sarcopenia and with low measured values of muscle mass, handgrip, and gait-speed. Furthermore, multiple regression analysis identified that low 25(OH)D status was associated with a high prevalence of severe sarcopenia (OR 6.00; 95% CI 1.99–18.08). In components of sarcopenia, both low physical performance and muscle mass were associated with low 25(OH) status. In conclusion, vitamin D levels are associated with severe sarcopenia and its components, and modification of vitamin D status including vitamin D supplementation may play a role in improving sarcopenia in RA.

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Habitual fish intake negatively correlates with prevalence of frailty among patients with rheumatoid arthritis

Cited by 14 publications

References 34 publications

Frailty in people with rheumatoid arthritis: a systematic review of observational studies

Frailty in people with rheumatoid arthritis: a systematic review of observational studies

Influence of dietary habits on depression among patients with rheumatoid arthritis: A cross-sectional study using KURAMA cohort database

Influence of serum vitamin D status on severe sarcopenia among female patients with rheumatoid arthritis: the KURAMA database

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