Habitual dietary intake of β-carotene, vitamin C, folate, or vitamin E may interact with single nucleotide polymorphisms on brachial–ankle pulse wave velocity in healthy adults

Park, Clara Yongjoo; Jung, Sukyoung; Kim, Mi Kyung; Choi, Bo Youl; Shin, Min Ho; Shin, Dong Hoon; Lee, Young Ho; Chun, Bo Young; Hong, Kyung Won; Hwang, Joo Yeon

doi:10.1007/s00394-015-0896-z

Cited by 5 publications

(4 citation statements)

References 59 publications

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“…In our study, the multivariate CCA analysis showed baPWV to have a negative association in both women and men with the carotenoids, retinol and vitamins considered in the study. These results are in accordance with the work done by Park et al [27] in a cohort of multicultural communities in Korea, where the intake of β-carotene, vitamin C, folate, or vitamin E was also found to be negatively associated with baPWV.…”

Section: Discussionsupporting

confidence: 93%

Multivariate Analysis of Influence of Vitamin Intake on Vascular Function Parameters by Sex in the General Spanish Population: EVA Study

Patino-Alonso

et al. 2020

Nutrients

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The influence of vitamin intake on vascular function parameters in the Spanish general population has not been studied. The main objective of this study is to analyze the influence of vitamin intake on vascular function and as a secondary objective the adequacy of vitamin intake in a sample of the Spanish population without previous cardiovascular disease and analyze the differences according to sex. Methods: We included 501 individuals obtained by simple random sampling with replacement (reference population 43,946). The average age was 55.90 ± 14.24 years, 49.70% men. Participants recorded the intake of vitamins using the EVIDENT app, previously validated, during a period of 3 days. Vascular function was assessed by measuring carotid-femoral pulse wave velocity (cfPWV) with the SphygmoCor device, cardio-ankle vascular index (CAVI) with the VaSera device and brachial-ankle pulse wave velocity (baPWV) by using a validated equation. Results: The vitamins with the least adequate intake was vitamin D, less than 5%, and vitamin B9, less than 35%. Vitamins with an adequate intake percentage, close to 100%, were B12 and B6. The multiple regression analysis showed a negative association between cfPWV and vitamin B2 in both sexes, and a positive one with retinol in men and B3 in women. baPWV was negatively associated with vitamins B1 and B12 in women and B9 in men, while being positively linked with B6 in men. CAVI presented a negative association with vitamin D in women. The results were similar in the canonical correspondence analysis. In conclusion, the results of this study suggest that the influence of vitamins on vascular function is not homogeneous and varies according to the parameter analyzed. Thus, in men, vitamins B2 and retinol were associated with cfPWV and vitamins B6 and B9 with baPWV. In women, vitamins B2 and B3 were related cfPWV, vitamins B1 and B12 with cfPWV and vitamin D with CAVI.

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Section: Discussionsupporting

confidence: 93%

Multivariate Analysis of Influence of Vitamin Intake on Vascular Function Parameters by Sex in the General Spanish Population: EVA Study

Patino-Alonso

et al. 2020

Nutrients

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“…Association studies have demonstrated that ZNF618 may be involved in the occurrence of cleft lip [33], high blood pressure [34], kidney diseases [35] and, in women, in brachial-ankle pulse wave velocity and arterial stiffness [36, 37]. On the basis of these clinical characteristics, we excluded this gene as a candidate gene.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis implications of the whole genome sequencing in a large Lebanese family with hyaline fibromatosis syndrome

et al. 2017

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BackgroundHyaline fibromatosis syndrome (HFS) is a recently introduced alternative term for two disorders that were previously known as juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH). These two variants are secondary to mutations in the anthrax toxin receptor 2 gene (ANTXR2) located on chromosome 4q21. The main clinical features of both entities include papular and/or nodular skin lesions, gingival hyperplasia, joint contractures and osteolytic bone lesions that appear in the first few years of life, and the syndrome typically progresses with the appearance of new lesions.MethodsWe describe five Lebanese patients from one family, aged between 28 and 58 years, and presenting with nodular and papular skin lesions, gingival hyperplasia, joint contractures and bone lesions. Because of the particular clinical features and the absence of a clinical diagnosis, Whole Genome Sequencing (WGS) was carried out on DNA samples from the proband and his parents.ResultsA mutation in ANTXR2 (p. Gly116Val) that yielded a diagnosis of HFS was noted.ConclusionsThe main goal of this paper is to add to the knowledge related to the clinical and radiographic aspects of HFS in adulthood and to show the importance of Next-Generation Sequencing (NGS) techniques in resolving such puzzling cases.

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“…Combined supplementation of vitamins C and E was ineffective in improving endothelial function in 14 randomized trials, including 597 participants, regardless of age, duration, dose, or baseline plasma concentration of vitamins [ 99 ]. Park et al demonstrated that higher intake of beta-carotene, vitamins C, E, and folate may protect individuals genetically vulnerable to stiffening of the arteries, in a study including 3,198 healthy men and women from the Korea Multirural communities, quantifiyng dietary intakes by a food frequency questionnaire [ 111 ].…”

Section: Vitamin Ementioning

confidence: 99%

Crosstalk between Vitamins A, B12, D, K, C, and E Status and Arterial Stiffness

2017

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Arterial stiffness is associated with cardiovascular risk, morbidity, and mortality. The present paper reviews the main vitamins related to arterial stiffness and enabling destiffening, their mechanisms of action, providing a brief description of the latest studies in the area, and their implications for primary cardiovascular prevention, clinical practice, and therapy. Despite inconsistent evidence for destiffening induced by vitamin supplementation in several randomized clinical trials, positive results were obtained in specific populations. The main mechanisms are related to antiatherogenic effects, improvement of endothelial function (vitamins A, C, D, and E) and metabolic profile (vitamins A, B12, C, D, and K), inhibition of the renin-angiotensin-aldosterone system (vitamin D), anti-inflammatory (vitamins A, D, E, and K) and antioxidant effects (vitamins A, C, and E), decrease of homocysteine level (vitamin B12), and reversing calcification of arteries (vitamin K). Vitamins A, B12, C, D, E, and K status is important in evaluating cardiovascular risk, and vitamin supplementation may be an effective, individualized, and inexpensive destiffening therapy.

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Habitual dietary intake of β-carotene, vitamin C, folate, or vitamin E may interact with single nucleotide polymorphisms on brachial–ankle pulse wave velocity in healthy adults

Cited by 5 publications

References 59 publications

Multivariate Analysis of Influence of Vitamin Intake on Vascular Function Parameters by Sex in the General Spanish Population: EVA Study

Multivariate Analysis of Influence of Vitamin Intake on Vascular Function Parameters by Sex in the General Spanish Population: EVA Study

Diagnosis implications of the whole genome sequencing in a large Lebanese family with hyaline fibromatosis syndrome

Crosstalk between Vitamins A, B12, D, K, C, and E Status and Arterial Stiffness

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