Habitual alcohol seeking: Modeling the transition from casual drinking to addiction

Barker, Jacqueline M.; Taylor, Jane R.

doi:10.1016/j.neubiorev.2014.08.012

Cited by 73 publications

(64 citation statements)

References 192 publications

(209 reference statements)

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“…There is now considerable evidence that the aDLS is gradually engaged to underlie wellestablished, habitual drug seeking (Barker & Taylor 2014, Belin et al 2009, Everitt 2014, Everitt & Robbins 2013. Initial observations of dorsal striatal DA release during the performance of a well-trained cocaine-seeking task (Ito et al 2002) and decreases of such responding by intra-DLS DA receptor blockade (in the absence of effects in the nucleus accumbens) (Vanderschuren et al 2005) have been reinforced by recent studies (Corbit et al 2012, Zapata et al 2010), but with the additional finding that aDLS DA receptor blockade earlier during acquisition of cocaine-seeking behavior was ineffective (Murray et al 2012).…”

Section: Imbalance Between Goal-directed and Habitual Behaviormentioning

confidence: 99%

Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

Everitt

Robbins

2016

Annu. Rev. Psychol.

919

773

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A decade ago, we hypothesized that drug addiction can be viewed as a transition from voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by a transition from prefrontal cortical to striatal control over drug seeking and taking as well as a progression from the ventral to the dorsal striatum. Here, in the light of burgeoning, supportive evidence, we reconsider and elaborate this hypothesis, in particular the refinements in our understanding of ventral and dorsal striatal mechanisms underlying goal-directed and habitual drug seeking, the influence of drug-associated Pavlovian-conditioned stimuli on drug seeking and relapse, and evidence for impairments in top-down prefrontal cortical inhibitory control over this behavior. We further review animal and human studies that have begun to define etiological factors and individual differences in the propensity to become addicted to drugs, leading to the description of addiction endophenotypes, especially for cocaine addiction. We consider the prospect of novel treatments for addiction that promote abstinence from and relapse to drug use.

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Section: Imbalance Between Goal-directed and Habitual Behaviormentioning

confidence: 99%

Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

Everitt

Robbins

2016

Annu. Rev. Psychol.

919

773

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“…Alcohol-related cues, including the sight and smell of alcohol drinks, acquire conditioned incentive properties (Barker and Taylor, 2014;Field and Duka, 2002), can provoke intense craving in individuals that abuse or have lost control over alcohol (Ludwig, 1986;De Bruijn et al, 2004), and may be a predictor of relapse after abstinence (Schneekloth et al, 2012).…”

Section: Cue-controlled Alcohol-seeking Behavioral Proceduresmentioning

confidence: 99%

The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking

Giuliano

Goodlett

Economidou

et al. 2015

Neuropsychopharmacol

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Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consummatory behaviors may jointly contribute to alcohol addiction. To develop an effective translational animal model that illuminates this interaction, daily seeking responses, maintained by alcohol-associated conditioned stimuli (CSs), need to be dissociated from alcohol drinking behavior. For this, we established a procedure whereby alcohol seeking maintained by alcohol-associated CSs is followed by a period during which rats have the opportunity to drink alcohol. This cue-controlled alcohol-seeking procedure was used to compare the effects of naltrexone and GSK1521498, a novel selective μ-opioid receptor antagonist, on both voluntary alcohol-intake and alcohol-seeking behaviors. Rederived alcohol-preferring, alcohol-nonpreferring, and high-alcohol-drinking replicate 1 line of rats (Indiana University) first received 18 sessions of 24 h home cage access to 10% alcohol and water under a 2-bottle choice procedure. They were trained subsequently to respond instrumentally for access to 15% alcohol under a second-order schedule of reinforcement, in which a prolonged period of alcohol-seeking behavior was maintained by contingent presentations of an alcohol-associated CS acting as a conditioned reinforcer. This seeking period was terminated by 20 min of free alcohol drinking access that achieved significant blood alcohol concentrations. The influence of pretreatment with either naltrexone (0.1 − 1 − 3 mg/kg) or GSK1521498 (0.1-1-3 mg/kg) before instrumental sessions was measured on both seeking and drinking behaviors, as well as on drinking in the 2-bottle choice procedure. Naltrexone and GSK1521498 dose-dependently reduced both cue-controlled alcohol seeking and alcohol intake in the instrumental context as well as alcohol intake in the choice procedure. However, GSK1521498 showed significantly greater effectiveness than naltrexone, supporting its potential use for promoting abstinence and preventing relapse in alcohol addiction.

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“…In the literature, one of the most debated distinctions in drug CR is the Bhigh-order CR^and Blow-order CR^di-chotomy (Tiffany, 1990; for a review, see Tiffany & Wray, 2012). The high-order CR phenomenon is mediated by the ventral striatum (i.e., non-automatic, conscious, sequential, and slow phenomena; David et al, 2005), as opposed to the low-order CR phenomenon, mediated by the dorsal striatum (i.e., automatic, non-conscious, parallel, and fast phenomena; McClernon, Kozink, Lutz, & Rose, 2009; for reviews, see Barker & Taylor, 2014;Everitt & Robbins, 2005;Wilson, Sayette, & Fiez, 2004). This view hypothesizes that the progression from use to abuse and then dependence may be characterized as the transition from voluntary to habitual and progressively compulsive drug use.…”

Section: Motor Cognition In Asd: Motor Anomalies Impacting On Social mentioning

confidence: 99%

The motor way: Clinical implications of understanding and shaping actions with the motor system in autism and drug addiction

Casartelli

Chiamulera

2015

Cogn Affect Behav Neurosci

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To understand others' minds is crucial for survival; however, it is quite puzzling how access to others' minds can be-to some extent-direct and not necessarily mediated by conceptual reasoning. Recent advances in neuroscience have led to hypothesize a role for motor circuits not only in controlling the elementary physical features of movement (e.g., force, direction, and amplitude), but also in understanding and shaping human behavior. The concept of Bmotor cognition^refers to these aspects, and neurophysiological, neuroimaging, and behavioral studies in human and nonhuman primates support this view. From a clinical perspective, motor cognition represents a challenge in several domains. A thorough investigation of the neural mechanisms mediating motor action/intention understanding and automatized/compulsive behaviors seems to be a promising way to tackle a range of neurodevelopmental and drug-related disorders. On the one hand, anomalies in motor cognition may have cascade effects on social functioning in individuals with autism spectrum disorder (ASD); on the other, motor cognition may help explain the pathophysiology of drug-seeking and drug-taking behaviors in the most severe phase of drug addiction (i.e., see drug dependence, motor low-order cue reactivity). This may represent a promising approach that could improve the efficacy of rehabilitative interventions. The only way to shed light on multifactorial disorders such as ASD and drug addiction is through the investigation of their multiple factors. This motor way can promote new theoretical and experimental perspectives that would help bridge the gap between the basic neuroscience approach and clinical practice.

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Habitual alcohol seeking: Modeling the transition from casual drinking to addiction

Cited by 73 publications

References 192 publications

Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking

The motor way: Clinical implications of understanding and shaping actions with the motor system in autism and drug addiction

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