Haarwachstum, Leberwerte und Lichtempfindlichkeit unter oraler Retinoid-Therapie bei Psoriasis

Abstract

In a multicentre, cooperative study into the treatment of extensive psoriasis with a new aromatic retinoid (Ro 10--9359) trichogram, liver function tests and the light erythema threshold were investigated. In some of the patients hair loss occurred, usually in the fifth to eighth week after a total dose of 1.9 g retinoid. In all cases this improved an average of six weeks after dose reduction or cessation of treatment. The trichogram in 27 patients showed a diffuse toxic hair loss. In 70% the effluvium was telogenic, in 22% telogen-dystrophic. GPT, GOT, alkaline phosphatase and prothrombin index showed no significant alterations during retinoid treatment. However, in individual cases there was a rise in GOT and GPT up to 80 U/l. Furthermore there was a statistical tendency in rising bilirubin levels. Finally there was no evidence for an increase in light sensitivity after three weeks of retinoid treatment. Measurement of the erythema threshold showed rather more a reduction in light sensitivity under treatment.

Toxic Hepatitis due to Combination Therapy with Methotrexate and Etretinate in Psoriasis

“…The acute changes in the liver could be caused by Tigason although a multicenter trial including 291 patients showed only few abnormal S-GPT values [3]. A few well-doc umented cases of toxic hepatitis due to Tiga son have been reported previously [1], In our case, it is difficult to place the re sponsibility for the severe toxic hepatitis on either drug alone.…”

Oral retinoids-present status

“…It ceases after 6-8 weeks if treatment is discontinued. Hair root evaluation showed a telogen effluvium in 70% of cases, whereas in 22% of cases telogen and dystrophic anagen roots were found (Mahrle et al, 1979).…”

Curling of Hair in Two Female Patients Taking Alitretinoin

“…These RXR receptors are speculated to play a role in new hair growth [ 9 ]. Etretinate may cause accelerated hair growth, dose-dependent telogen effluvium, and, at a high dose, hair loss that may be associated with dystrophy of hair roots [ 8 ]. It is speculative whether the affected hairs have regrown in follicles from which hairs have previously been lost.…”