HA particles as resourceful cancer, steroidal and antibiotic drug delivery device with sustainable and multiple drug release capability

Advances in Hyaluronic Acid for Biomedical Applications

“…Moreover, HA results in the skin being softer, radiant, and smoother, which are attributed to its capability of replenishing moisture and holding water ( Altman et al, 2019 ). HA is used for all types of skin because it is non-toxic, non-allergic, and non-sensitizing ( Sahiner et al, 2020 ). In addition, it also participates in several important biological functions, such as manipulation, motility, differentiation and proliferation of skin cells, and biomechanical properties ( Omer et al, 2019 ).…”

Fungal Keratitis Treatment Using Drug-Loaded Hyaluronic Acid Microgels

“…27,28 Drug carrying vehicles can be designed as sustainable release systems providing slow and long-term active agent release functioning over time by making use of chemical and physical interactions between drug molecules and polymeric networks. 29 To generate these types of carrier systems, three main drug-loading processes of adsorption, conjugation, and encapsulation have been utilized. 29,30 Especially, chemical linking (i.e., conjugation) and entrapment (i.e., encapsulation) of drugs in polymeric networks provide more advantages such as increased drug-loading capacity, improved drug solubility and bioavailability, boosted drug release amounts, as well as slow and sustainable drug delivery periods.…”

“…29 To generate these types of carrier systems, three main drug-loading processes of adsorption, conjugation, and encapsulation have been utilized. 29,30 Especially, chemical linking (i.e., conjugation) and entrapment (i.e., encapsulation) of drugs in polymeric networks provide more advantages such as increased drug-loading capacity, improved drug solubility and bioavailability, boosted drug release amounts, as well as slow and sustainable drug delivery periods. 31 The present research aimed to develop hyaluronic acid (HA)-based drug carriers for the treatment of fungal keratitis against Fusarium sp.…”

“…Thus, HA is biocompatible, biodegradable, and nontoxic and has smart biodistribution and natural targeting ability, e.g., for CD44 receptors; also, HA-derived micro/nanogels have modifiable surface chemistry and morphology. , The chemical structure of HA, consisting of d -glucuronic acid and N -acetyl- d -glucosamine repeating disaccharide units, is suitable for conjugation reactions with various drug molecules through hydroxyl or carboxylic acid groups . The use of HA and HA-based materials in ophthalmological applications is very appealing because of their inherent properties such as intraocular safety, improved biocompatibility of carrier materials, enhancement of corneal and conjunctival cell proliferation and epithelium healing, as well as use for the treatment of dry eyes and abundant presence in tear fluid and vitreous humor. , Therefore, HA micro/nanogels can be further utilized as a more effective treatment avenue for ocular delivery. , Drug carrying vehicles can be designed as sustainable release systems providing slow and long-term active agent release functioning over time by making use of chemical and physical interactions between drug molecules and polymeric networks . To generate these types of carrier systems, three main drug-loading processes of adsorption, conjugation, and encapsulation have been utilized. , Especially, chemical linking (i.e., conjugation) and entrapment (i.e., encapsulation) of drugs in polymeric networks provide more advantages such as increased drug-loading capacity, improved drug solubility and bioavailability, boosted drug release amounts, as well as slow and sustainable drug delivery periods .…”

“…The use of HA and HA-based materials in ophthalmological applications is very appealing because of their inherent properties such as intraocular safety, improved biocompatibility of carrier materials, enhancement of corneal and conjunctival cell proliferation and epithelium healing, as well as use for the treatment of dry eyes and abundant presence in tear fluid and vitreous humor. , Therefore, HA micro/nanogels can be further utilized as a more effective treatment avenue for ocular delivery. , Drug carrying vehicles can be designed as sustainable release systems providing slow and long-term active agent release functioning over time by making use of chemical and physical interactions between drug molecules and polymeric networks . To generate these types of carrier systems, three main drug-loading processes of adsorption, conjugation, and encapsulation have been utilized. , Especially, chemical linking (i.e., conjugation) and entrapment (i.e., encapsulation) of drugs in polymeric networks provide more advantages such as increased drug-loading capacity, improved drug solubility and bioavailability, boosted drug release amounts, as well as slow and sustainable drug delivery periods . The present research aimed to develop hyaluronic acid (HA)-based drug carriers for the treatment of fungal keratitis against Fusarium sp.…”