H3t-Labelled Blood Cells in the CNS Response to Axotomies at Various Times After Isotope Injection

Young, Margaret B.

doi:10.1097/00005072-197705000-00005

Cited by 11 publications

(2 citation statements)

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“…It is well estab lished that neuroglia, as well as vascular and perivascular cells, react in a special manner to direct and indirect insult. For example, retrograde degeneration, as a response to peripheral nerve injury, is known to induce an increase in the neuroglial population around responsive neurons [Sjostrand, 1966;Young, 1977]; the effect of more direct injury is loss of both neurons and sur rounding neuroglia [ Weitbrecht and Noetzel, 1976], On the other hand a demyelinating condition such as created by intracerebral injection of weanling JHM mice with mouse hepatitis virus is accompanied by increased labeling of both astrocytes and oligodendro cytes, as well as of vascular endothelial cells and some oligodendroglial satellite cells [Herndon et al, 1976]. This, as these authors suggest, indicates that some of the Oligodendroglia must be newly formed by division either from mature cells or from precursor cells; this also concurs with views held regarding oligodendroglial reaction to sublethal injury, and demyelination in gen eral [Hurst, 1944;Lewis and Swank, 1953;Koenig et al, 1962;Ibrahim and Adams, 1963;Ibrahim ex al., 1974],…”

Section: Discussionmentioning

confidence: 99%

The mast cells of the mammalian central nervous system

Ibrahim¹,

Koshayan²,

Khreis³

1980

Cells Tissues Organs

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The central nervous system (CNS) of two mammalian species was studied autoradiographically using tritium-labeled thymidine; the rat, whose brain contains few localized mast cells (MCs) but many ubiquitous neurolipomastocytoid cells (NLMs), and the guinea pig, whose brain contains only ubiquitous NLMs. A few guinea pigs were also injected with an MC discharger compound 48/80 and the response of the NLMs, which are thought to be allied to MCs, as well as of neuroglial and vascular endothelial cells, was noted. The rats were 3 days to 6 weeks old whereas all the guinea pigs were young adults. Both MCs and NLMs took up the label, and much more so in the babies, paralleling similar uptakes in only very small immature MCs outside the CNS. Neuroglial elements, especially subependymal and oligodendroglial, as well as endothelial, perivascular, leptomeningeal and ependymal cells demonstrated some uptake. This was considerably increased upon receipt of compound 48/80, especially in the case of the subependymal glia, the NLMs and the endothelial cells; capillary neoformations were seen in the spinal cords of guinea pigs that had shown signs of paralysis. The cause of this increase is discussed in terms of mild stress induced by that compound. The subependymal response is also discussed with reference to periventricular plaques seen in multiple sclerosis and lymphoreticular and glial tumors seen in that region. It is concluded that both MCs and NLMs are capable of DNA replication and mitosis in immature animals. The NLMs can also divide upon stimulation in adult CNS.

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Section: Discussionmentioning

confidence: 99%

The mast cells of the mammalian central nervous system

Ibrahim¹,

Koshayan²,

Khreis³

1980

Cells Tissues Organs

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“…1975Kitamura et al. 1977: Young, 1977: Imamoto and Leblond. 1977: Blinzingeretal.. 1978: Adrian et al.…”

Section: Introductionunclassified

Nature of Macrophages in Rat Brain

Boya¹,

Calvo²,

Carbonell³

et al. 1986

Cells Tissues Organs

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The nature of phagocytes appearing in lesions of the central nervous system is strongly debated with a tendency to assess an exclusively hematogenous origin. We studied the origin of phagocytes appearing in a stab wound in the rat brain. Histochemical stains for acid phosphatase and peroxidase, and silver impregnation techniques were used for our study. The results obtained showed the existence of two macrophage types: endogenous microghocytes and exogenous monocytes.

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Intraspinal non‐neuronal cellular responses to peripheral nerve injury

Gilmore

Skinner

1979

Anat. Rec.

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The accumulation of non-vascular, non-neuronal cells (designated herein as reactive cells) in association with perikarya of axotomized motor neurons has been described by many investigators. Recently Gilmore ('75) found that sciatic axotomy in immature rats resulted in the occurrence of reactive cells not only in the spinal ventral gray matter but also in the dorsal gray matter. To determine if the presence of these cells in the dorsal gray matter, a finding not reported by others, was related to the immaturity of the animal, sciatic axotomy was performed in rats ranging in age from 17 days to 16 months in the present study. Light microscopic evaluation of the spinal cords three or seven days post-operatively showed that the reactive cells occurred consistently in both dorsal and ventral gray matter irrespective of age. Transection of tibial nerve or the nerve to the medial head of the gastrocnemius muscle elicited a cellular response in both dorsal and ventral gray matter, although transection of the latter nerve resulted in a much less obvious response. Crushing of the sciatic nerve was followed by a response of reactive cells not qualitatively different from that noted following transection. Transection of the sural nerve, primarily a sensory nerve, resulted in the presence of reactive cells in dorsal gray matter but not in the environs of motor neurons in the ventral gray matter. These findings suggest that the reactive cells in the dorsal gray matter of the spinal cord are associated with altered central processes of dorsal root ganglion cells.

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H3t-Labelled Blood Cells in the CNS Response to Axotomies at Various Times After Isotope Injection

Cited by 11 publications

References 0 publications

The mast cells of the mammalian central nervous system

The mast cells of the mammalian central nervous system

Nature of Macrophages in Rat Brain

Intraspinal non‐neuronal cellular responses to peripheral nerve injury

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