Abstract:Epigenetic dysregulation is pervasive in cancer, frequently impairing normal tissue development and differentiation1. Beyond alterations in histone modifying enzymes, 'oncohistone' mutations have been described across a variety of cancers2-4, although the in vivo effects and underlying mechanisms behind these observations have not been well-studied and remain unclear. Here, by inducing the in vivo expression of histone H3.3 carrying a lysine to methionine (K to M) mutation at position 36 (H3K36M) in self-renew… Show more
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