H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition

Nancy, Patrice; Siewiera, Johan; Rizzuto, Gabrielle; Tagliani, Elisa; Osokine, Ivan; Manandhar, Priyanka; Dolgalev, Igor; Clementi, Caterina; Tsirigos, Aristotelis; Erlebacher, Adrian

doi:10.1172/jci95937

Cited by 49 publications

(57 citation statements)

References 52 publications

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“…The lower Il10 expression in the placenta also suggests that the decidua is more active in anti-inflammatory responses ( Figure S1A). As recently reported (Nancy et al, 2018), RNA-seq data in purified stromal cells on days 8 and 16 of pregnancy show highest Tlr4 expression in deciduae, supporting our results and suggesting a potential role of TLR4 in the decidua (Figures S1B and S1C). Our in situ hybridization (ISH) results show that the expression of TLR4 is highly localized in day 16 deciduae with much lower expression in the placenta ( Figure 1C), suggesting that the decidua is a potential site that modulates the balance between inflammation and anti-inflammation.…”

Section: Differential Tlr4 Expression In the Decidua And Placentasupporting

confidence: 92%

Endothelial Cells in the Decidual Bed Are Potential Therapeutic Targets for Preterm Birth Prevention

et al. 2019

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Section: Differential Tlr4 Expression In the Decidua And Placentasupporting

confidence: 92%

Endothelial Cells in the Decidual Bed Are Potential Therapeutic Targets for Preterm Birth Prevention

et al. 2019

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“…Examples in the opossum ESF are the upregulation of catalase and SOD to break down H 2 O 2 , the activation of the NRF2 signaling pathway that leads to the production of ROS‐detoxifying enzymes like glutathione peroxidases (e.g., GPX3/4), and the fact that activated FOXO1 protein protects against apoptosis . In contrast, the phenotype of the DSC is both enabling and limiting trophoblast invasion, as well as modifying the reaction of the innate immune system to the perturbation caused by the embryo . Therefore, the function of the DSC is not only to protect the cell from damage, like the stress reaction seen in opossum, but also to compensate for the effects of the stressor: embryo attachment, inflammation, and invasion.…”

Section: Siei Generates Novel Cell Typesmentioning

confidence: 99%

Stress‐Induced Evolutionary Innovation: A Mechanism for the Origin of Cell Types

Wagner¹,

Erkenbrack²,

Love

2019

BioEssays

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Understanding the evolutionary role of environmentally induced phenotypic variation (i.e., plasticity) is an important issue in developmental evolution. A major physiological response to environmental change is cellular stress, which is counteracted by generic stress reactions detoxifying the cell. A model, stress‐induced evolutionary innovation (SIEI), whereby ancestral stress reactions and their corresponding pathways can be transformed into novel structural components of body plans, such as new cell types, is described. Previous findings suggest that the cell differentiation cascade of a cell type critical to pregnancy in humans, the decidual stromal cell, evolved from a cellular stress reaction. It is hypothesized that the stress reaction in these cells was elicited ancestrally via inflammation caused by embryo attachment. The present study proposes that SIEI is a distinct form of plasticity‐based evolutionary change leading to the origin of novel structures rather than adaptive transformation of pre‐existing characters.

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“…Examples in the opossum ESF are the upregulation of catalase and SOD to break down H2O2, the activation of the NRF2 signaling pathway that leads to the production of ROSdexotifying enzymes like glutathione peroxidases (e.g., GPX3/4), and the fact that activated FOXO1 protein in the opossum ESF is protective against apoptosis (Erkenbrack, Maziarz et al, 2018). In contrast, the phenotype of the DSC is directly engaging the intruding trophoblast by both enabling and limiting trophoblast invasion, as well as modifying the reaction of the innate immune system to the perturbation caused by embryo invasion 36,37 . Therefore, the function of the DSC is not only to protect the cell from damage, like the stress reaction seen in opossum, but also to compensate for the effects of the stressor: embryo attachment, inflammation, and invasion.…”

Section: Peeling Away the Particulars: A Model Of Stress-induced Evolmentioning

confidence: 99%

Stress-Induced Evolutionary Innovation: A Mechanism for the Origin of Cell Types

Wagner¹,

Erkenbrack²,

Love

2018

Preprint

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Understanding the evolutionary role of environmentally-induced phenotypic variation (i.e., environmental plasticity) is an important issue in developmental evolution. One of the major physiological responses to environmental changes is cellular stress, which is counteracted by a generic stress reaction that detoxifies the cell, refolds proteins, and repairs DNA damage. In this paper, we elaborate on a previous finding suggesting that the cell differentiation cascade of human decidual stromal cells, a cell type critical for embryo implantation and the maintenance of pregnancy, evolved from a cellular stress reaction. We hypothesize that the stress reaction in these cells was elicited ancestrally through the inflammation caused by embryo attachment and invasion. We describe a model, Stress-Induced Evolutionary Innovation (SIEI), whereby ancestral stress reactions and their corresponding pathways can be transformed into novel structural components of body plans, such as new cell types. After reviewing similarities and differences between SIEI and the “plasticity first hypothesis” (PFH) of evolution, we argue that SIEI is a distinct form of plasticity-based evolutionary change because it leads to the origin of novel structures rather than the adaptive transformation of a pre-existing character.

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H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition

Cited by 49 publications

References 52 publications

Endothelial Cells in the Decidual Bed Are Potential Therapeutic Targets for Preterm Birth Prevention

Endothelial Cells in the Decidual Bed Are Potential Therapeutic Targets for Preterm Birth Prevention

Stress‐Induced Evolutionary Innovation: A Mechanism for the Origin of Cell Types

Stress-Induced Evolutionary Innovation: A Mechanism for the Origin of Cell Types

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