H3K27Ac modification and gene expression in psoriasis

Masalha, Moamen; Ben‐Dov, Iddo Z.; Ram, Oren; Meningher, Tal; Jacob‐Hirsch, Jasmine; Kassem, Riad; Sidi, Yechezkel; Avni, Dror

doi:10.1016/j.jdermsci.2021.07.003

Cited by 15 publications

(13 citation statements)

References 48 publications

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“…Another study identified grainyhead-like 2 (GRHL2) binding at the promoter region of target gene EDC, which might inhibit the recruitment of histone demethylase Jmjd3 to the EDC promoters and increase the level of H3K27me3 leading to the inhibition of keratinocyte differentiation ( 22 ). ChIP-seq with anti-H3K27Ac in psoriatic and healthy skin identified an overexpressed enrichment of H3K27Ac in psoriasis ( 23 ). HDAC1 was overexpressed in psoriasis patients while SIRT1 was decreased in the basal layer of psoriasis patients compared to healthy controls ( 146 ).…”

Section: Histone Modifications In Inflammatory Diseasesmentioning

confidence: 99%

Role of Histone Post-Translational Modifications in Inflammatory Diseases

et al. 2022

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Inflammation is a defensive reaction for external stimuli to the human body and generally accompanied by immune responses, which is associated with multiple diseases such as atherosclerosis, type 2 diabetes, Alzheimer’s disease, psoriasis, asthma, chronic lung diseases, inflammatory bowel disease, and multiple virus-associated diseases. Epigenetic mechanisms have been demonstrated to play a key role in the regulation of inflammation. Common epigenetic regulations are DNA methylation, histone modifications, and non-coding RNA expression; among these, histone modifications embrace various post-modifications including acetylation, methylation, phosphorylation, ubiquitination, and ADP ribosylation. This review focuses on the significant role of histone modifications in the progression of inflammatory diseases, providing the potential target for clinical therapy of inflammation-associated diseases.

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Section: Histone Modifications In Inflammatory Diseasesmentioning

confidence: 99%

Role of Histone Post-Translational Modifications in Inflammatory Diseases

et al. 2022

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“…GRHL2 acts as an essential transcription factor for epithelial-to-mesenchymal transitions and estrogen-induced transcription in breast cancer [ 39 , 40 ]. A recent study showed that H3K27Ac-enriched genes harbor a putative GRHL transcription factor-binding site in psoriasis [ 41 ]. However, the roles of TBP and GRHL2 in ovaries remain unknown.…”

Section: Discussionmentioning

confidence: 99%

Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation

Jin

Ren

et al. 2023

Epigenetics & Chromatin

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Background Epigenetic reprogramming is involved in luteinizing hormone (LH)-induced ovulation; however, the underlying mechanisms are largely unknown. Results We here observed a rapid histone deacetylation process between two waves of active transcription mediated by the follicle-stimulating hormone (FSH) and the LH congener human chorionic gonadotropin (hCG), respectively. Analysis of the genome-wide H3K27Ac distribution in hCG-treated granulosa cells revealed that a rapid wave of genome-wide histone deacetylation remodels the chromatin, followed by the establishment of specific histone acetylation for ovulation. HDAC2 phosphorylation activation coincides with histone deacetylation in mouse preovulatory follicles. When HDAC2 was silenced or inhibited, histone acetylation was retained, leading to reduced gene transcription, retarded cumulus expansion, and ovulation defect. HDAC2 phosphorylation was associated with CK2α nuclear translocation, and inhibition of CK2α attenuated HDAC2 phosphorylation, retarded H3K27 deacetylation, and inactivated the ERK1/2 signaling cascade. Conclusions This study demonstrates that the ovulatory signal erases histone acetylation through activation of CK2α-mediated HDAC2 phosphorylation in granulosa cells, which is an essential prerequisite for subsequent successful ovulation.

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“…GLS1-mediated glutaminolysis induces proliferation of KCs in PsO and promotes Th17 and γδ T17 cell differentiation through the acetylation of H3 on Il17a promoter [ 94 ]. The first whole-genome study for histone modifications showed that H3K27 is hyperacetylated in 60% of the overexpressed gene promoters in cutaneous lesions and binding sites of overexpressed TFs in lesional skin, such as GRHL [ 95 ] ( Figure 1 ). WT1 , a TF implicated in cell proliferation and apoptosis, is highly expressed in psoriatic skin lesions and has two binding sites in the IL-1β gene promoter.…”

Section: Histone Modificationsmentioning

confidence: 99%

Contribution of the Environment, Epigenetic Mechanisms and Non-Coding RNAs in Psoriasis

et al. 2022

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Despite the increasing research and clinical interest in the predisposition of psoriasis, a chronic inflammatory skin disease, the multitude of genetic and environmental factors involved in its pathogenesis remain unclear. This complexity is further exacerbated by the several cell types that are implicated in Psoriasis’s progression, including keratinocytes, melanocytes and various immune cell types. The observed interactions between the genetic substrate and the environment lead to epigenetic alterations that directly or indirectly affect gene expression. Changes in DNA methylation and histone modifications that alter DNA-binding site accessibility, as well as non-coding RNAs implicated in the post-transcriptional regulation, are mechanisms of gene transcriptional activity modification and therefore affect the pathways involved in the pathogenesis of Psoriasis. In this review, we summarize the research conducted on the environmental factors contributing to the disease onset, epigenetic modifications and non-coding RNAs exhibiting deregulation in Psoriasis, and we further categorize them based on the under-study cell types. We also assess the recent literature considering therapeutic applications targeting molecules that compromise the epigenome, as a way to suppress the inflammatory cutaneous cascade.

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H3K27Ac modification and gene expression in psoriasis

Cited by 15 publications

References 48 publications

Role of Histone Post-Translational Modifications in Inflammatory Diseases

Role of Histone Post-Translational Modifications in Inflammatory Diseases

Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation

Contribution of the Environment, Epigenetic Mechanisms and Non-Coding RNAs in Psoriasis

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